Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia

Mohamad Mohty, Richard M. Szydlo, Agnes S M Yong, Jane F. Apperley, John M. Goldman, Junia V. Melo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Expression of CD7, ELA-2, PR-3, and the polycomb group gene BMI-1 reflects the intrinsic heterogeneity and predicts prognosis of patients with chronic myeloid leukemia (CML) who were not treated with allogeneic stem cell transplantation (allo-SCT). This study investigated whether expression of these genes determined outcome following allo-SCT in a cohort of 84 patients with chronic-phase (CP) CML. We found that patients expressing BMI-1 at a "high" level before allo-SCT had an improved overall survival (P=.005) related to a reduced transplantation-related mortality. In multivariate analysis, when adjusted for the European Group for Blood and Marrow Transplantation (EBMT)-Gratwohl score and other prognostic factors, there was an independent association between BMI-1 expression and grades 2 to 4 acute graft-versus-host disease (relative risk [RR]=2.85; 95% confidence interval [CI], 1.3-6.4; P=.011), suggesting that BMI-1 measured prior to allo-SCT can serve as a biomarker for predicting outcome in patients with CP-CML receiving allo-SCT, and may thus contribute to better therapeutic decisions.

LanguageEnglish
Pages2163-2166
Number of pages4
JournalBlood
Volume112
Issue number5
DOIs
Publication statusPublished - 1 Sep 2008

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Mohty, Mohamad ; Szydlo, Richard M. ; Yong, Agnes S M ; Apperley, Jane F. ; Goldman, John M. ; Melo, Junia V. / Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia. In: Blood. 2008 ; Vol. 112, No. 5. pp. 2163-2166.
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abstract = "Expression of CD7, ELA-2, PR-3, and the polycomb group gene BMI-1 reflects the intrinsic heterogeneity and predicts prognosis of patients with chronic myeloid leukemia (CML) who were not treated with allogeneic stem cell transplantation (allo-SCT). This study investigated whether expression of these genes determined outcome following allo-SCT in a cohort of 84 patients with chronic-phase (CP) CML. We found that patients expressing BMI-1 at a {"}high{"} level before allo-SCT had an improved overall survival (P=.005) related to a reduced transplantation-related mortality. In multivariate analysis, when adjusted for the European Group for Blood and Marrow Transplantation (EBMT)-Gratwohl score and other prognostic factors, there was an independent association between BMI-1 expression and grades 2 to 4 acute graft-versus-host disease (relative risk [RR]=2.85; 95{\%} confidence interval [CI], 1.3-6.4; P=.011), suggesting that BMI-1 measured prior to allo-SCT can serve as a biomarker for predicting outcome in patients with CP-CML receiving allo-SCT, and may thus contribute to better therapeutic decisions.",
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Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia. / Mohty, Mohamad; Szydlo, Richard M.; Yong, Agnes S M; Apperley, Jane F.; Goldman, John M.; Melo, Junia V.

In: Blood, Vol. 112, No. 5, 01.09.2008, p. 2163-2166.

Research output: Contribution to journalArticle

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