Assessment of progression and regression of coronary atherosclerosis by intravascular ultrasound. A new paradigm shift?

Stephen Nicholls, Ilke Sipahi, E. Murat Tuzcu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Intravascular ultrasound (IVUS) has emerged as a powerful imaging modality for the assessment of the arterial wall and it's response to the accumulation of atherosclerotic plaque. The ability to image the coronary arteries on a serial basis provides a unique opportunity for IVUS to monitor the impact that potential anti-atherosclerotic strategies exert on plaque burden. As a result, studies incorporating serial IVUS imaging as the primary endpoint have demonstrated that therapeutic strategies that modify LDL, HDL and blood pressure in patients with established coronary artery disease can have a profound impact on the progression of atherosclerotic plaque. This heralds a paradigm shift that emphasizes plaque regression as a potential target in the development of preventive strategies.

Translated title of the contributionAssessment of progression and regression of coronary atherosclerosis by intravascular ultrasound. A new paradigm shift?
LanguageSpanish
Pages57-66
Number of pages10
JournalRevista Espanola de Cardiologia
Volume59
Issue number1
DOIs
Publication statusPublished - 1 Jan 2006

Keywords

  • Coronary artery disease
  • Coronary atherosclerosis
  • Coronary imaging
  • Intravascular ultrasound
  • Plaque progression/regression

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Evaluaci{\'o}n de la progresi{\'o}n y la regresi{\'o}n de la aterosclerosis coronaria mediante ecograf{\'i}a intravascular. ¿ Un nuevo cambio de paradigma?",
abstract = "Intravascular ultrasound (IVUS) has emerged as a powerful imaging modality for the assessment of the arterial wall and it's response to the accumulation of atherosclerotic plaque. The ability to image the coronary arteries on a serial basis provides a unique opportunity for IVUS to monitor the impact that potential anti-atherosclerotic strategies exert on plaque burden. As a result, studies incorporating serial IVUS imaging as the primary endpoint have demonstrated that therapeutic strategies that modify LDL, HDL and blood pressure in patients with established coronary artery disease can have a profound impact on the progression of atherosclerotic plaque. This heralds a paradigm shift that emphasizes plaque regression as a potential target in the development of preventive strategies.",
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Evaluación de la progresión y la regresión de la aterosclerosis coronaria mediante ecografía intravascular. ¿ Un nuevo cambio de paradigma? / Nicholls, Stephen; Sipahi, Ilke; Tuzcu, E. Murat.

In: Revista Espanola de Cardiologia, Vol. 59, No. 1, 01.01.2006, p. 57-66.

Research output: Contribution to journalArticle

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T1 - Evaluación de la progresión y la regresión de la aterosclerosis coronaria mediante ecografía intravascular. ¿ Un nuevo cambio de paradigma?

AU - Nicholls, Stephen

AU - Sipahi, Ilke

AU - Tuzcu, E. Murat

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AB - Intravascular ultrasound (IVUS) has emerged as a powerful imaging modality for the assessment of the arterial wall and it's response to the accumulation of atherosclerotic plaque. The ability to image the coronary arteries on a serial basis provides a unique opportunity for IVUS to monitor the impact that potential anti-atherosclerotic strategies exert on plaque burden. As a result, studies incorporating serial IVUS imaging as the primary endpoint have demonstrated that therapeutic strategies that modify LDL, HDL and blood pressure in patients with established coronary artery disease can have a profound impact on the progression of atherosclerotic plaque. This heralds a paradigm shift that emphasizes plaque regression as a potential target in the development of preventive strategies.

KW - Coronary artery disease

KW - Coronary atherosclerosis

KW - Coronary imaging

KW - Intravascular ultrasound

KW - Plaque progression/regression

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