Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography: A comparison with 2D-echocardiography

Fleur R. De Graaf, Joanne D. Schuijf, Joëlla E. Van Velzen, Gaetano Nucifora, Lucia J. Kroft, Albert De Roos, Martin J. Schalij, J. Wouter Jukema, Ernst E. Van Der Wall, Jeroen J. Bax

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Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocardiography as the standard of reference. Methods and Results: A head-to-head comparison between 320-row MDCT and 2D-echocardiography was performed in 114 patients (68 men; mean age 62 ± 13 years) who were clinically referred for MDCT coronary angiography. The entire heart was imaged in a single heartbeat, using prospective dose modulation. LV end-diastolic volumes (LVEDV) and LV endsystolic volumes (LVESV) were determined and the LV ejection fraction (LVEF) was derived. Average LVEF was 60 ± 10% (range 26-78%) as determined on MDCT, compared with 59 ± 10% (range 25-77%) on 2D-echocardiography. Evaluation of LVEF by linear regression analysis showed a good correlation between MDCT and 2D-echocardiography (r2 = .87; P < .001). Good correlations between MDCT and 2D-echocardiography were demonstrated for the assessment of LVEDV (r2 = .91; P < .001) and LVESV (r2 = .94; P < .001). At Bland-Altman analysis, mean differences (±SD) of 7.3 ± 12.1 mL (P < .05) and 1.8 ± 7.4 mL (P < .05) were observed between MDCT and 2D-echocardiography for LVEDV and LVESV, respectively. LVEF was slightly overestimated with MDCT (.9 ± 3.6%; P < .05). Conclusions: Accurate assessment of LV function and volumes is feasible with single heartbeat 320-row MDCT in patients referred for MDCT coronary angiography.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalJournal of Nuclear Cardiology
Issue number2
Publication statusPublished - Apr 2010


  • Cardiac imaging
  • Left ventricular function
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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