Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography: A comparison with 2D-echocardiography

Fleur R. De Graaf, Joanne D. Schuijf, Joëlla E. Van Velzen, Gaetano Nucifora, Lucia J. Kroft, Albert De Roos, Martin J. Schalij, J. Wouter Jukema, Ernst E. Van Der Wall, Jeroen J. Bax

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocardiography as the standard of reference. Methods and Results: A head-to-head comparison between 320-row MDCT and 2D-echocardiography was performed in 114 patients (68 men; mean age 62 ± 13 years) who were clinically referred for MDCT coronary angiography. The entire heart was imaged in a single heartbeat, using prospective dose modulation. LV end-diastolic volumes (LVEDV) and LV endsystolic volumes (LVESV) were determined and the LV ejection fraction (LVEF) was derived. Average LVEF was 60 ± 10% (range 26-78%) as determined on MDCT, compared with 59 ± 10% (range 25-77%) on 2D-echocardiography. Evaluation of LVEF by linear regression analysis showed a good correlation between MDCT and 2D-echocardiography (r2 = .87; P < .001). Good correlations between MDCT and 2D-echocardiography were demonstrated for the assessment of LVEDV (r2 = .91; P < .001) and LVESV (r2 = .94; P < .001). At Bland-Altman analysis, mean differences (±SD) of 7.3 ± 12.1 mL (P < .05) and 1.8 ± 7.4 mL (P < .05) were observed between MDCT and 2D-echocardiography for LVEDV and LVESV, respectively. LVEF was slightly overestimated with MDCT (.9 ± 3.6%; P < .05). Conclusions: Accurate assessment of LV function and volumes is feasible with single heartbeat 320-row MDCT in patients referred for MDCT coronary angiography.

LanguageEnglish
Pages225-231
Number of pages7
JournalJournal of Nuclear Cardiology
Volume17
Issue number2
DOIs
Publication statusPublished - 1 Apr 2010

Keywords

  • Cardiac imaging
  • Left ventricular function
  • Multidetector computed tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

De Graaf, Fleur R. ; Schuijf, Joanne D. ; Van Velzen, Joëlla E. ; Nucifora, Gaetano ; Kroft, Lucia J. ; De Roos, Albert ; Schalij, Martin J. ; Wouter Jukema, J. ; Van Der Wall, Ernst E. ; Bax, Jeroen J. / Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography : A comparison with 2D-echocardiography. In: Journal of Nuclear Cardiology. 2010 ; Vol. 17, No. 2. pp. 225-231.
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abstract = "Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocardiography as the standard of reference. Methods and Results: A head-to-head comparison between 320-row MDCT and 2D-echocardiography was performed in 114 patients (68 men; mean age 62 ± 13 years) who were clinically referred for MDCT coronary angiography. The entire heart was imaged in a single heartbeat, using prospective dose modulation. LV end-diastolic volumes (LVEDV) and LV endsystolic volumes (LVESV) were determined and the LV ejection fraction (LVEF) was derived. Average LVEF was 60 ± 10{\%} (range 26-78{\%}) as determined on MDCT, compared with 59 ± 10{\%} (range 25-77{\%}) on 2D-echocardiography. Evaluation of LVEF by linear regression analysis showed a good correlation between MDCT and 2D-echocardiography (r2 = .87; P < .001). Good correlations between MDCT and 2D-echocardiography were demonstrated for the assessment of LVEDV (r2 = .91; P < .001) and LVESV (r2 = .94; P < .001). At Bland-Altman analysis, mean differences (±SD) of 7.3 ± 12.1 mL (P < .05) and 1.8 ± 7.4 mL (P < .05) were observed between MDCT and 2D-echocardiography for LVEDV and LVESV, respectively. LVEF was slightly overestimated with MDCT (.9 ± 3.6{\%}; P < .05). Conclusions: Accurate assessment of LV function and volumes is feasible with single heartbeat 320-row MDCT in patients referred for MDCT coronary angiography.",
keywords = "Cardiac imaging, Left ventricular function, Multidetector computed tomography",
author = "{De Graaf}, {Fleur R.} and Schuijf, {Joanne D.} and {Van Velzen}, {Jo{\"e}lla E.} and Gaetano Nucifora and Kroft, {Lucia J.} and {De Roos}, Albert and Schalij, {Martin J.} and {Wouter Jukema}, J. and {Van Der Wall}, {Ernst E.} and Bax, {Jeroen J.}",
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De Graaf, FR, Schuijf, JD, Van Velzen, JE, Nucifora, G, Kroft, LJ, De Roos, A, Schalij, MJ, Wouter Jukema, J, Van Der Wall, EE & Bax, JJ 2010, 'Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography: A comparison with 2D-echocardiography', Journal of Nuclear Cardiology, vol. 17, no. 2, pp. 225-231. https://doi.org/10.1007/s12350-009-9173-y

Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography : A comparison with 2D-echocardiography. / De Graaf, Fleur R.; Schuijf, Joanne D.; Van Velzen, Joëlla E.; Nucifora, Gaetano; Kroft, Lucia J.; De Roos, Albert; Schalij, Martin J.; Wouter Jukema, J.; Van Der Wall, Ernst E.; Bax, Jeroen J.

In: Journal of Nuclear Cardiology, Vol. 17, No. 2, 01.04.2010, p. 225-231.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography

T2 - Journal of Nuclear Cardiology

AU - De Graaf, Fleur R.

AU - Schuijf, Joanne D.

AU - Van Velzen, Joëlla E.

AU - Nucifora, Gaetano

AU - Kroft, Lucia J.

AU - De Roos, Albert

AU - Schalij, Martin J.

AU - Wouter Jukema, J.

AU - Van Der Wall, Ernst E.

AU - Bax, Jeroen J.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocardiography as the standard of reference. Methods and Results: A head-to-head comparison between 320-row MDCT and 2D-echocardiography was performed in 114 patients (68 men; mean age 62 ± 13 years) who were clinically referred for MDCT coronary angiography. The entire heart was imaged in a single heartbeat, using prospective dose modulation. LV end-diastolic volumes (LVEDV) and LV endsystolic volumes (LVESV) were determined and the LV ejection fraction (LVEF) was derived. Average LVEF was 60 ± 10% (range 26-78%) as determined on MDCT, compared with 59 ± 10% (range 25-77%) on 2D-echocardiography. Evaluation of LVEF by linear regression analysis showed a good correlation between MDCT and 2D-echocardiography (r2 = .87; P < .001). Good correlations between MDCT and 2D-echocardiography were demonstrated for the assessment of LVEDV (r2 = .91; P < .001) and LVESV (r2 = .94; P < .001). At Bland-Altman analysis, mean differences (±SD) of 7.3 ± 12.1 mL (P < .05) and 1.8 ± 7.4 mL (P < .05) were observed between MDCT and 2D-echocardiography for LVEDV and LVESV, respectively. LVEF was slightly overestimated with MDCT (.9 ± 3.6%; P < .05). Conclusions: Accurate assessment of LV function and volumes is feasible with single heartbeat 320-row MDCT in patients referred for MDCT coronary angiography.

AB - Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocardiography as the standard of reference. Methods and Results: A head-to-head comparison between 320-row MDCT and 2D-echocardiography was performed in 114 patients (68 men; mean age 62 ± 13 years) who were clinically referred for MDCT coronary angiography. The entire heart was imaged in a single heartbeat, using prospective dose modulation. LV end-diastolic volumes (LVEDV) and LV endsystolic volumes (LVESV) were determined and the LV ejection fraction (LVEF) was derived. Average LVEF was 60 ± 10% (range 26-78%) as determined on MDCT, compared with 59 ± 10% (range 25-77%) on 2D-echocardiography. Evaluation of LVEF by linear regression analysis showed a good correlation between MDCT and 2D-echocardiography (r2 = .87; P < .001). Good correlations between MDCT and 2D-echocardiography were demonstrated for the assessment of LVEDV (r2 = .91; P < .001) and LVESV (r2 = .94; P < .001). At Bland-Altman analysis, mean differences (±SD) of 7.3 ± 12.1 mL (P < .05) and 1.8 ± 7.4 mL (P < .05) were observed between MDCT and 2D-echocardiography for LVEDV and LVESV, respectively. LVEF was slightly overestimated with MDCT (.9 ± 3.6%; P < .05). Conclusions: Accurate assessment of LV function and volumes is feasible with single heartbeat 320-row MDCT in patients referred for MDCT coronary angiography.

KW - Cardiac imaging

KW - Left ventricular function

KW - Multidetector computed tomography

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U2 - 10.1007/s12350-009-9173-y

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JF - Journal of Nuclear Cardiology

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