Assessment and interpretation of sleep disordered breathing severity in cardiology: Clinical implications and perspectives

Dominik Linz, Mathias Baumert, Peter Catcheside, John Floras, Prash Sanders, Patrick Lévy, Martin R. Cowie, R. Doug McEvoy

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sleep disordered breathing (SDB) is highly prevalent in patients with atrial fibrillation, heart failure and hypertension and is associated with increased risk of mortality, cardiovascular (CV) events and arrhythmias. Current assessment of the severity of SDB is mainly based on the apnea-hypopnea index (AHI) representing the number of hypopneas and apneas per hour of sleep. However, this event-based parameter alone may not sufficiently reflect the complex pathophysiological mechanisms underlying SDB potentially contributing to CV outcome risk. In this review article, we highlight important limitations and pitfalls of current assessment, quantification and interpretation of SDB-severity in patients with CV disease and will discuss pathophysiological considerations from preclinical and clinical mechanistic studies and possible clinical implications.

LanguageEnglish
Pages281-288
Number of pages8
JournalInternational Journal of Cardiology
Volume271
DOIs
Publication statusPublished - 15 Nov 2018

Keywords

  • Arrhythmias
  • Atrial fibrillation
  • Heart failure
  • Hypoxia
  • Sleep apnea
  • Sleep disordered breathing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Linz, Dominik ; Baumert, Mathias ; Catcheside, Peter ; Floras, John ; Sanders, Prash ; Lévy, Patrick ; Cowie, Martin R. ; Doug McEvoy, R. / Assessment and interpretation of sleep disordered breathing severity in cardiology : Clinical implications and perspectives. In: International Journal of Cardiology. 2018 ; Vol. 271. pp. 281-288.
@article{305c22f3c0a2417694b498c8ba45c455,
title = "Assessment and interpretation of sleep disordered breathing severity in cardiology: Clinical implications and perspectives",
abstract = "Sleep disordered breathing (SDB) is highly prevalent in patients with atrial fibrillation, heart failure and hypertension and is associated with increased risk of mortality, cardiovascular (CV) events and arrhythmias. Current assessment of the severity of SDB is mainly based on the apnea-hypopnea index (AHI) representing the number of hypopneas and apneas per hour of sleep. However, this event-based parameter alone may not sufficiently reflect the complex pathophysiological mechanisms underlying SDB potentially contributing to CV outcome risk. In this review article, we highlight important limitations and pitfalls of current assessment, quantification and interpretation of SDB-severity in patients with CV disease and will discuss pathophysiological considerations from preclinical and clinical mechanistic studies and possible clinical implications.",
keywords = "Arrhythmias, Atrial fibrillation, Heart failure, Hypoxia, Sleep apnea, Sleep disordered breathing",
author = "Dominik Linz and Mathias Baumert and Peter Catcheside and John Floras and Prash Sanders and Patrick L{\'e}vy and Cowie, {Martin R.} and {Doug McEvoy}, R.",
year = "2018",
month = "11",
day = "15",
doi = "10.1016/j.ijcard.2018.04.076",
language = "English",
volume = "271",
pages = "281--288",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

Assessment and interpretation of sleep disordered breathing severity in cardiology : Clinical implications and perspectives. / Linz, Dominik; Baumert, Mathias; Catcheside, Peter; Floras, John; Sanders, Prash; Lévy, Patrick; Cowie, Martin R.; Doug McEvoy, R.

In: International Journal of Cardiology, Vol. 271, 15.11.2018, p. 281-288.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment and interpretation of sleep disordered breathing severity in cardiology

T2 - International Journal of Cardiology

AU - Linz, Dominik

AU - Baumert, Mathias

AU - Catcheside, Peter

AU - Floras, John

AU - Sanders, Prash

AU - Lévy, Patrick

AU - Cowie, Martin R.

AU - Doug McEvoy, R.

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Sleep disordered breathing (SDB) is highly prevalent in patients with atrial fibrillation, heart failure and hypertension and is associated with increased risk of mortality, cardiovascular (CV) events and arrhythmias. Current assessment of the severity of SDB is mainly based on the apnea-hypopnea index (AHI) representing the number of hypopneas and apneas per hour of sleep. However, this event-based parameter alone may not sufficiently reflect the complex pathophysiological mechanisms underlying SDB potentially contributing to CV outcome risk. In this review article, we highlight important limitations and pitfalls of current assessment, quantification and interpretation of SDB-severity in patients with CV disease and will discuss pathophysiological considerations from preclinical and clinical mechanistic studies and possible clinical implications.

AB - Sleep disordered breathing (SDB) is highly prevalent in patients with atrial fibrillation, heart failure and hypertension and is associated with increased risk of mortality, cardiovascular (CV) events and arrhythmias. Current assessment of the severity of SDB is mainly based on the apnea-hypopnea index (AHI) representing the number of hypopneas and apneas per hour of sleep. However, this event-based parameter alone may not sufficiently reflect the complex pathophysiological mechanisms underlying SDB potentially contributing to CV outcome risk. In this review article, we highlight important limitations and pitfalls of current assessment, quantification and interpretation of SDB-severity in patients with CV disease and will discuss pathophysiological considerations from preclinical and clinical mechanistic studies and possible clinical implications.

KW - Arrhythmias

KW - Atrial fibrillation

KW - Heart failure

KW - Hypoxia

KW - Sleep apnea

KW - Sleep disordered breathing

UR - http://www.scopus.com/inward/record.url?scp=85046153434&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2018.04.076

DO - 10.1016/j.ijcard.2018.04.076

M3 - Article

VL - 271

SP - 281

EP - 288

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -