Are You Listening? Facilitation of the Auditory Blink Response in People with Fibromyalgia

Carolyn Berryman, Sarah B. Wallwork, Alberto Marcos Heredia-Rizo, Emma Knight, Danny Camfferman, Leslie Russek, G. Lorimer Moseley

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The purpose of the current study was to determine whether auditory prepulse inhibition (PPI) and/or prepulse facilitation (PPF) were altered in people with fibromyalgia (FM) when compared with controls. Eyeblink responses were recorded from 29 females with FM and 27 controls, while they listened to 3 blocks of auditory stimuli that delivered pulses with either PPI or PPF. Using a linear mixed model, our main findings were that there was a GROUP*CONDITION interaction (F4, 1084 = 4.01, P= .0031) indicating that the difference in amplitude between FM group and control group changed depending on the condition (PPI or PPF). Post hoc tests revealed no differences between the groups in response to PPI. The FM group showed a greater reactivity of response to the PPF conditioned stimulus than the control group did (t(39.7) = 2.03, P= .0494). Augmentation of PPF, as demonstrated by the FM group is thought to be linked to alterations in information processing mediated by an autonomically driven general orienting process. Activities that decrease autonomic drive or rebalance autonomic and parasympathetic tone such as vagal stimulation might be pursued as effective interventions for people with FM. Perspective: This article presents evidence of preservation of neural circuitry that underpins response suppression and evidence of neural circuit disturbance mediated by autonomic drive-in people with FM. These results are important because intact circuitry underpins the effectiveness of therapies and may be harnessed, and rebalancing autonomic drive may be indicated.

Original languageEnglish
Pages (from-to)1072-1083
Number of pages12
JournalJournal of Pain
Issue number9
Publication statusPublished or Issued - Sep 2021


  • Fibromyalgia
  • auditory blink response
  • autonomic drive
  • prepulse facilitation
  • prepulse inhibition

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this