Are sensitized patients better off with a desensitization transplant or waiting on dialysis?

Philip A. Clayton, P. Toby Coates

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Abstract

Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation. Two large observational studies have recently addressed the question of whether individuals are better off with a desensitization treatment followed by HLA-incompatible living donor transplantation or waiting on the deceased donor kidney transplant list for a compatible transplant. The conflicting results of these 2 studies largely reflect differences in the study design and study population, leaving clinicians to make decisions about desensitization based largely on local expertise and anticipated waiting times for a compatible deceased donor transplant.

LanguageEnglish
Pages1266-1268
Number of pages3
JournalKidney International
Volume91
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology

Cite this

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abstract = "Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation. Two large observational studies have recently addressed the question of whether individuals are better off with a desensitization treatment followed by HLA-incompatible living donor transplantation or waiting on the deceased donor kidney transplant list for a compatible transplant. The conflicting results of these 2 studies largely reflect differences in the study design and study population, leaving clinicians to make decisions about desensitization based largely on local expertise and anticipated waiting times for a compatible deceased donor transplant.",
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Are sensitized patients better off with a desensitization transplant or waiting on dialysis? / Clayton, Philip A.; Coates, P. Toby.

In: Kidney International, Vol. 91, No. 6, 01.06.2017, p. 1266-1268.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Are sensitized patients better off with a desensitization transplant or waiting on dialysis?

AU - Clayton, Philip A.

AU - Coates, P. Toby

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation. Two large observational studies have recently addressed the question of whether individuals are better off with a desensitization treatment followed by HLA-incompatible living donor transplantation or waiting on the deceased donor kidney transplant list for a compatible transplant. The conflicting results of these 2 studies largely reflect differences in the study design and study population, leaving clinicians to make decisions about desensitization based largely on local expertise and anticipated waiting times for a compatible deceased donor transplant.

AB - Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation. Two large observational studies have recently addressed the question of whether individuals are better off with a desensitization treatment followed by HLA-incompatible living donor transplantation or waiting on the deceased donor kidney transplant list for a compatible transplant. The conflicting results of these 2 studies largely reflect differences in the study design and study population, leaving clinicians to make decisions about desensitization based largely on local expertise and anticipated waiting times for a compatible deceased donor transplant.

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DO - 10.1016/j.kint.2017.04.004

M3 - Comment/debate

VL - 91

SP - 1266

EP - 1268

JO - Kidney International

T2 - Kidney International

JF - Kidney International

SN - 0085-2538

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ER -