Aortic elastic properties are related to left ventricular diastolic function in patients with type 1 diabetes mellitus

Theodoros D. Karamitsos, Haralambos I. Karvounis, Triantafyllos P. Didangelos, Christodoulos E. Papadopoulos, Melania K. Kachrimanidou, Joseph B. Selvanayagam, Georgios E. Parharidis

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Objective: The aim of the study was to evaluate left ventricular diastolic function and its relation to aortic wall stiffness in patients with type 1 diabetes mellitus without coronary artery disease or hypertension. Patients: Sixty-six patients with type 1 diabetes mellitus were examined by echocardiography and divided into two groups according to the diastolic filling pattern determined by mitral annulus tissue Doppler velocities. Group A patients (n = 21) presented diastolic dysfunction with a peak early diastolic mitral annular velocity (Em)/peak late diastolic mitral annular velocity (Am) ratio <1 whereas in group B patients (n = 45) the Em/Am ratio was >1. Coronary artery disease was excluded based on normal thallium scintigraphy. Aortic stiffness index was calculated from aortic diameters measured by echocardiography, using accepted criteria. Results: Aortic stiffness index differed significantly among the two groups. Significant correlations were found between parameters of left ventricular diastolic function (Em/Am, isovolumic relaxation time, deceleration time) and aortic stiffness index. Multiple stepwise linear regression analysis revealed aortic stiffness index (β = -0.39, p = 0.001) and isovolumic relaxation time (β = -0.46, p < 0.001) as the main predictors of Em/Am ratio. Conclusions: Aortic stiffness is increased in type 1 diabetic patients with left ventricular diastolic dysfunction. This impairment in aortic elastic properties seems to be related to parameters of diastolic function.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
Issue number2
Publication statusPublished - 1 Jan 2008
Externally publishedYes


  • Aortic stiffness
  • Diabetes mellitus, type 1
  • Diastolic dysfunction
  • Doppler echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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