Aortic atheroma burden predicts acute cerebrovascular events after transcatheter aortic valve implantation: Insights from volumetric multislice computed tomography analysis

Yu Kataoka, Rishi Puri, Anthony D. Pisaniello, Muhammad Hammadah, Mohammed Qintar, Kiyoko Uno, Joseph K. Montarello, Stephen J. Nicholls, Stephen G. Worthley

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aims: Embolisation of atheromatous debris during catheter manipulation is considered to underlie acute cerebrovascular events (CVE) after transcatheter aortic valve implantation (TAVI). However, the relationship between aorta atheroma burden and acute CVE after TAVI has not been established. We investigated the impact of aorta atheroma burden on acute CVE. Methods and results: Preoperative multislice computed tomographic (MSCT) images in 278 patients receiving TAVI were analysed. Total atheroma volume (TAV) was calculated by measuring aorta vessel and lumen areas in every 1 mm cross-sectional image. Acute CVE was observed in 16 patients. Patients having acute CVE were more likely to have a prior CVE (p=0.002), and to exhibit greater TAV in the ascending aorta (12.8±3.5 vs. 7.0±2.1 cm3, p<0.001) and the aortic arch (3.1±1.6 vs. 1.2±0.2 cm3, p<0.001). TAV in the ascending aorta >10.3 cm3 and in the aortic arch >2.9 cm3 predicted acute CVE. The incidence of acute CVE was highest (36.4%) if patients had a prior CVE and TAV in the ascending aorta and the aortic arch above cut-offs. Conclusions: Patients with acute CVE after TAVI had greater aorta atheroma burden. Our findings might underscore preoperative MSCT analysis of aorta atherosclerosis to identify high-risk patients for acute CVE, who might require an embolic protection device during TAVI.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalEuroIntervention
Volume12
Issue number6
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • Aortic valve implantation
  • Aortic valve stenosis
  • Atherosclerosis
  • Computed tomography
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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