Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

Suthagar Pillai Piaru, Roziahanim Mahmud, Amin Malik Shah Abdul Majid, Zeyad Nassar

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

LanguageEnglish
Pages294-298
Number of pages5
JournalAsian Pacific Journal of Tropical Medicine
Volume5
Issue number4
DOIs
Publication statusPublished - 1 Apr 2012
Externally publishedYes

Keywords

  • Antiangiogenic
  • Antioxidant
  • Essential oil
  • Morinda citrifolia
  • Myristica fragrans

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Piaru, Suthagar Pillai ; Mahmud, Roziahanim ; Abdul Majid, Amin Malik Shah ; Nassar, Zeyad. / Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. In: Asian Pacific Journal of Tropical Medicine. 2012 ; Vol. 5, No. 4. pp. 294-298.
@article{08435f88cecb42fd819ea91602ada310,
title = "Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia",
abstract = "Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1){\%} while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4){\%}. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.",
keywords = "Antiangiogenic, Antioxidant, Essential oil, Morinda citrifolia, Myristica fragrans",
author = "Piaru, {Suthagar Pillai} and Roziahanim Mahmud and {Abdul Majid}, {Amin Malik Shah} and Zeyad Nassar",
year = "2012",
month = "4",
day = "1",
doi = "10.1016/S1995-7645(12)60042-X",
language = "English",
volume = "5",
pages = "294--298",
journal = "Asian Pacific Journal of Tropical Medicine",
issn = "1995-7645",
number = "4",

}

Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. / Piaru, Suthagar Pillai; Mahmud, Roziahanim; Abdul Majid, Amin Malik Shah; Nassar, Zeyad.

In: Asian Pacific Journal of Tropical Medicine, Vol. 5, No. 4, 01.04.2012, p. 294-298.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

AU - Piaru, Suthagar Pillai

AU - Mahmud, Roziahanim

AU - Abdul Majid, Amin Malik Shah

AU - Nassar, Zeyad

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

AB - Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

KW - Antiangiogenic

KW - Antioxidant

KW - Essential oil

KW - Morinda citrifolia

KW - Myristica fragrans

UR - http://www.scopus.com/inward/record.url?scp=84858771097&partnerID=8YFLogxK

U2 - 10.1016/S1995-7645(12)60042-X

DO - 10.1016/S1995-7645(12)60042-X

M3 - Article

VL - 5

SP - 294

EP - 298

JO - Asian Pacific Journal of Tropical Medicine

T2 - Asian Pacific Journal of Tropical Medicine

JF - Asian Pacific Journal of Tropical Medicine

SN - 1995-7645

IS - 4

ER -