Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

Suthagar Pillai Piaru, Roziahanim Mahmud, Amin Malik Shah Abdul Majid, Zeyad Nassar

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42 Citations (Scopus)


Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils. Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations. Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC 50 value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC 50 of 77.64 μg/mL comparing to mengkudu oil which exhibits IC 50 of 109.30 μg/mL. Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

Original languageEnglish
Pages (from-to)294-298
Number of pages5
JournalAsian Pacific Journal of Tropical Medicine
Issue number4
Publication statusPublished - 1 Apr 2012


  • Antiangiogenic
  • Antioxidant
  • Essential oil
  • Morinda citrifolia
  • Myristica fragrans

ASJC Scopus subject areas

  • Medicine(all)

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