Antimicrobial properties of lactoferrin

Håvard Jenssen, Robert E.W. Hancock

Research output: Contribution to journalReview articlepeer-review

298 Citations (Scopus)

Abstract

Milk is a vital nutritional source for the offspring of all mammals, including humans. In addition to its nutritional value, it is a rich source of proteins including lactoferrin. Lactoferrin is a truly multifunctional protein that has been studied extensively over the past decades. It is best known for its ability to bind iron, which eventually led to the discovery of its antibacterial activity. In addition, lactoferrin has demonstrated potent antiviral, antifungal and antiparasitic activity, towards a broad spectrum of species. It is also considered to be an important host defense molecule during infant development. In this review, we focus on the antimicrobial activities of lactoferrin with particular emphasis on antibacterial and antiviral activities, although its antifungal and -parasitic activity are also discussed.

Original languageEnglish
Pages (from-to)19-29
Number of pages11
JournalBiochimie
Volume91
Issue number1
DOIs
Publication statusPublished or Issued - Jan 2009
Externally publishedYes

Keywords

  • Antibacterial
  • Antifungal
  • Antiparasitic
  • Antiviral
  • Lactoferrin

ASJC Scopus subject areas

  • Biochemistry

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