Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr

Zeyad Nassar, Abdalrahim F.A. Aisha, Mohamed B.K. Ahamed, Zhari Ismail, Khalid M. Abu-Salah, Salman A. Alrokayan, Amin M.S. Abdul Majid

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant species was shown previously to have strong antiangiogenic activity; however the active ingredient(s) that conferred the biological activity and the mode of action was not established. Given the high concentration of KA in S. koetjape, an attempt has been made in this study to investigate the antiangiogenic properties of KA.Results: Treatment with 10-50 μg/ml KA resulted in dose dependent inhibition of new blood vessels growth in ex vivo rat aortic ring assay. KA was found to be non-cytotoxic against HUVECs with IC50 40.97 ± 0.37 μg/ml. KA inhibited major angiogenesis process steps, endothelial cell migration and differentiation as well as VEGF expression.Conclusions: The non-cytotoxic compound, KA, may be a potent antiangiogenic agent; its activity may be attributed to inhibition of endothelial cells migration and differentiation as well VEGF suppression.

LanguageEnglish
Article number12
JournalCancer Cell International
Volume11
DOIs
Publication statusPublished - 27 Apr 2011

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

Cite this

Nassar, Z., Aisha, A. F. A., Ahamed, M. B. K., Ismail, Z., Abu-Salah, K. M., Alrokayan, S. A., & Abdul Majid, A. M. S. (2011). Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr. Cancer Cell International, 11, [12]. https://doi.org/10.1186/1475-2867-11-12
Nassar, Zeyad ; Aisha, Abdalrahim F.A. ; Ahamed, Mohamed B.K. ; Ismail, Zhari ; Abu-Salah, Khalid M. ; Alrokayan, Salman A. ; Abdul Majid, Amin M.S. / Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr. In: Cancer Cell International. 2011 ; Vol. 11.
@article{26166fe06fa645c096a9d17852d188a9,
title = "Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr",
abstract = "Background: Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant species was shown previously to have strong antiangiogenic activity; however the active ingredient(s) that conferred the biological activity and the mode of action was not established. Given the high concentration of KA in S. koetjape, an attempt has been made in this study to investigate the antiangiogenic properties of KA.Results: Treatment with 10-50 μg/ml KA resulted in dose dependent inhibition of new blood vessels growth in ex vivo rat aortic ring assay. KA was found to be non-cytotoxic against HUVECs with IC50 40.97 ± 0.37 μg/ml. KA inhibited major angiogenesis process steps, endothelial cell migration and differentiation as well as VEGF expression.Conclusions: The non-cytotoxic compound, KA, may be a potent antiangiogenic agent; its activity may be attributed to inhibition of endothelial cells migration and differentiation as well VEGF suppression.",
author = "Zeyad Nassar and Aisha, {Abdalrahim F.A.} and Ahamed, {Mohamed B.K.} and Zhari Ismail and Abu-Salah, {Khalid M.} and Alrokayan, {Salman A.} and {Abdul Majid}, {Amin M.S.}",
year = "2011",
month = "4",
day = "27",
doi = "10.1186/1475-2867-11-12",
language = "English",
volume = "11",
journal = "Cancer Cell International",
issn = "1475-2867",

}

Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr. / Nassar, Zeyad; Aisha, Abdalrahim F.A.; Ahamed, Mohamed B.K.; Ismail, Zhari; Abu-Salah, Khalid M.; Alrokayan, Salman A.; Abdul Majid, Amin M.S.

In: Cancer Cell International, Vol. 11, 12, 27.04.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr

AU - Nassar, Zeyad

AU - Aisha, Abdalrahim F.A.

AU - Ahamed, Mohamed B.K.

AU - Ismail, Zhari

AU - Abu-Salah, Khalid M.

AU - Alrokayan, Salman A.

AU - Abdul Majid, Amin M.S.

PY - 2011/4/27

Y1 - 2011/4/27

N2 - Background: Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant species was shown previously to have strong antiangiogenic activity; however the active ingredient(s) that conferred the biological activity and the mode of action was not established. Given the high concentration of KA in S. koetjape, an attempt has been made in this study to investigate the antiangiogenic properties of KA.Results: Treatment with 10-50 μg/ml KA resulted in dose dependent inhibition of new blood vessels growth in ex vivo rat aortic ring assay. KA was found to be non-cytotoxic against HUVECs with IC50 40.97 ± 0.37 μg/ml. KA inhibited major angiogenesis process steps, endothelial cell migration and differentiation as well as VEGF expression.Conclusions: The non-cytotoxic compound, KA, may be a potent antiangiogenic agent; its activity may be attributed to inhibition of endothelial cells migration and differentiation as well VEGF suppression.

AB - Background: Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant species was shown previously to have strong antiangiogenic activity; however the active ingredient(s) that conferred the biological activity and the mode of action was not established. Given the high concentration of KA in S. koetjape, an attempt has been made in this study to investigate the antiangiogenic properties of KA.Results: Treatment with 10-50 μg/ml KA resulted in dose dependent inhibition of new blood vessels growth in ex vivo rat aortic ring assay. KA was found to be non-cytotoxic against HUVECs with IC50 40.97 ± 0.37 μg/ml. KA inhibited major angiogenesis process steps, endothelial cell migration and differentiation as well as VEGF expression.Conclusions: The non-cytotoxic compound, KA, may be a potent antiangiogenic agent; its activity may be attributed to inhibition of endothelial cells migration and differentiation as well VEGF suppression.

UR - http://www.scopus.com/inward/record.url?scp=79955132556&partnerID=8YFLogxK

U2 - 10.1186/1475-2867-11-12

DO - 10.1186/1475-2867-11-12

M3 - Article

VL - 11

JO - Cancer Cell International

T2 - Cancer Cell International

JF - Cancer Cell International

SN - 1475-2867

M1 - 12

ER -