Abstract
Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by pathological alterations in food intake. These disorders are more common among young females, although they can also affect males and older females. Rigid restriction of food intake, which can alternate with loss of control in the drive to eat, is the most striking behavioral change seen in patients with AN and BN, respectively. Some of the endocrine changes and clinical outcomes of patients with eating disorders are a mechanism to save energy and promote survival. Hypogonadism is the most striking endocrine change in patients with eating disorders, with amenorrhea as the main manifestation. Other endocrine alterations may include low T3 syndrome, hypercortisolism, loss of bone mineral density, and changes in the somatotropic axis and the glucose homeostasis. Hypoleptinemia, caused by food restriction and by the decrease of adipose tissue mass, seems to be the mediator of these endocrine changes. However, other adipocytokines and hormones involved in the regulation of food intake may also play a role in the development of the endocrine outcomes.
| Language | English |
|---|---|
| Title of host publication | Hormones, Brain and Behavior Online |
| Publisher | Elsevier Inc. |
| Pages | 2927-2944 |
| Number of pages | 18 |
| ISBN (Print) | 9780080887838 |
| DOIs | |
| Publication status | Published - 1 Jan 2009 |
Keywords
- Adrenal
- Amenorrhea
- Anorexia
- Bone
- Bulimia
- Eating disorders
- Endocrine
- Glucose
- Growth hormone
- Hypogonadism
- Insulin
- Leptin
- Nervosa
- Osteoporosis
- Thyroid
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
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Anorexia nervosa and bulimia nervosa. / Paz-Filho, G. J.; Licinio, J.
Hormones, Brain and Behavior Online. Elsevier Inc., 2009. p. 2927-2944.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Anorexia nervosa and bulimia nervosa
AU - Paz-Filho, G. J.
AU - Licinio, J.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by pathological alterations in food intake. These disorders are more common among young females, although they can also affect males and older females. Rigid restriction of food intake, which can alternate with loss of control in the drive to eat, is the most striking behavioral change seen in patients with AN and BN, respectively. Some of the endocrine changes and clinical outcomes of patients with eating disorders are a mechanism to save energy and promote survival. Hypogonadism is the most striking endocrine change in patients with eating disorders, with amenorrhea as the main manifestation. Other endocrine alterations may include low T3 syndrome, hypercortisolism, loss of bone mineral density, and changes in the somatotropic axis and the glucose homeostasis. Hypoleptinemia, caused by food restriction and by the decrease of adipose tissue mass, seems to be the mediator of these endocrine changes. However, other adipocytokines and hormones involved in the regulation of food intake may also play a role in the development of the endocrine outcomes.
AB - Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by pathological alterations in food intake. These disorders are more common among young females, although they can also affect males and older females. Rigid restriction of food intake, which can alternate with loss of control in the drive to eat, is the most striking behavioral change seen in patients with AN and BN, respectively. Some of the endocrine changes and clinical outcomes of patients with eating disorders are a mechanism to save energy and promote survival. Hypogonadism is the most striking endocrine change in patients with eating disorders, with amenorrhea as the main manifestation. Other endocrine alterations may include low T3 syndrome, hypercortisolism, loss of bone mineral density, and changes in the somatotropic axis and the glucose homeostasis. Hypoleptinemia, caused by food restriction and by the decrease of adipose tissue mass, seems to be the mediator of these endocrine changes. However, other adipocytokines and hormones involved in the regulation of food intake may also play a role in the development of the endocrine outcomes.
KW - Adrenal
KW - Amenorrhea
KW - Anorexia
KW - Bone
KW - Bulimia
KW - Eating disorders
KW - Endocrine
KW - Glucose
KW - Growth hormone
KW - Hypogonadism
KW - Insulin
KW - Leptin
KW - Nervosa
KW - Osteoporosis
KW - Thyroid
UR - http://www.scopus.com/inward/record.url?scp=84884809308&partnerID=8YFLogxK
U2 - 10.1016/B978-008088783-8.00093-0
DO - 10.1016/B978-008088783-8.00093-0
M3 - Chapter
SN - 9780080887838
SP - 2927
EP - 2944
BT - Hormones, Brain and Behavior Online
PB - Elsevier Inc.
ER -