Androgen control of lipid metabolism in prostate cancer: Novel insights and future applications

Lisa M. Butler, Margaret M. Centenera, Johannes V. Swinnen

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

One of the most typical hallmarks of prostate cancer cells is their exquisite dependence on androgens, which is the basis of the widely applied androgen deprivation therapy. Among the variety of key cellular processes and functions that are regulated by androgens, lipid metabolism stands out by its complex regulation and its many intricate links with cancer cell biology. Here, we review our current knowledge on the links between androgens and lipid metabolism in prostate cancer, and highlight recent developments and insights into the links between key oncogenic stimuli and altered lipid synthesis and/or uptake that may hold significant potential for biomarker development and provide new vulnerabilities for therapeutic intervention.

Original languageEnglish
Pages (from-to)R219-R227
JournalEndocrine-Related Cancer
Volume23
Issue number5
DOIs
Publication statusPublished - 1 May 2016

Keywords

  • Androgens
  • Lipid metabolism
  • Lipidomics
  • Lipogenic enzymes
  • Phospholipids
  • Prostate cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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