Amyloidogenic metal-binding proteins: New investigative pathways

Paul Davies, Sarah N. Fontaine, Dima Moualla, Xiaoyan Wang, Josephine Wright, David R. Brown

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Neurodegenerative diseases remain perplexing and problematic for modern research. Those associated with amyloidogenic proteins have often been lumped together simply because those proteins aggregate. However, research has identified a more logical reason to group some of these diseases together. The associated proteins not only aggregate, but also bind copper. The APP (amyloid precursor protein) binds copper in an N-terminal region. Binding of copper has been suggested to influence generation of β-amyloid from the protein. PrP (prion protein) binds copper, and this appears to be necessary for its normal function and might also reduce its probability of conversion into an infectious prion. α-Synuclein, a protein associated with Parkinson's disease, also binds copper, but, in this case, it potentially increases the rate at which the protein aggregates. The similarities between these proteins, in terms of metal binding, has allowed us to investigate them using similar approaches. In the present review, we discuss some of these approaches.

LanguageEnglish
Pages1299-1303
Number of pages5
JournalBiochemical Society Transactions
Volume36
Issue number6
DOIs
Publication statusPublished - 1 Dec 2008

Keywords

  • Alzheimer's disease
  • Amyloid precursor protein
  • Neurodegeneration
  • Parkinson's disease
  • Prion
  • Synuclein
  • Transmissible spongiform encephalopathy (TSE)

ASJC Scopus subject areas

  • Biochemistry

Cite this

Davies, P., Fontaine, S. N., Moualla, D., Wang, X., Wright, J., & Brown, D. R. (2008). Amyloidogenic metal-binding proteins: New investigative pathways. Biochemical Society Transactions, 36(6), 1299-1303. https://doi.org/10.1042/BST0361299
Davies, Paul ; Fontaine, Sarah N. ; Moualla, Dima ; Wang, Xiaoyan ; Wright, Josephine ; Brown, David R. / Amyloidogenic metal-binding proteins : New investigative pathways. In: Biochemical Society Transactions. 2008 ; Vol. 36, No. 6. pp. 1299-1303.
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Davies, P, Fontaine, SN, Moualla, D, Wang, X, Wright, J & Brown, DR 2008, 'Amyloidogenic metal-binding proteins: New investigative pathways', Biochemical Society Transactions, vol. 36, no. 6, pp. 1299-1303. https://doi.org/10.1042/BST0361299

Amyloidogenic metal-binding proteins : New investigative pathways. / Davies, Paul; Fontaine, Sarah N.; Moualla, Dima; Wang, Xiaoyan; Wright, Josephine; Brown, David R.

In: Biochemical Society Transactions, Vol. 36, No. 6, 01.12.2008, p. 1299-1303.

Research output: Contribution to journalReview article

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AU - Fontaine, Sarah N.

AU - Moualla, Dima

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AU - Brown, David R.

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