Amino acids and mTOR signalling in anabolic function

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Abstract

Amino acids regulate signalling through the mTORC1 (mammalian target of rapamycin, complex 1) and thereby control a number of components of the translational machinery, including initiation and elongation factors. mTORC1 also positively regulates other anabolic processes, in particular ribosome biogenesis. The most effective single amino acid is leucine. A key issue is how intracellular amino acids regulate mTORC1. This does not require the TSC1/2 (tuberous sclerosis complex 1/2) complex, which is involved in the activation of mTORC1, for example, by insulin. Progress in understanding the mechanisms responsible for this will be reviewed.

Original languageEnglish
Pages (from-to)1187-1190
Number of pages4
JournalBiochemical Society Transactions
Volume35
Issue number5
DOIs
Publication statusPublished - 1 Nov 2007

Keywords

  • Amino acid
  • Eukaryotic initiation factor 4E (eIF4E)
  • Eukaryotic initiation factor 4E-binding protein (4E-BP)
  • GTPase-activating protein (GAP)
  • Mammalian target of rapamycin (mTOR)
  • Tuberous sclerosis complex (TSC)

ASJC Scopus subject areas

  • Biochemistry

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