Alpha-synuclein and its role in metal binding: Relevance to Parkinson's disease

Josephine Wright, David R. Brown

Research output: Contribution to journalShort surveypeer-review

33 Citations (Scopus)

Abstract

Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals.

Original languageEnglish
Pages (from-to)496-503
Number of pages8
JournalJournal of Neuroscience Research
Volume86
Issue number3
DOIs
Publication statusPublished or Issued - 15 Feb 2008
Externally publishedYes

Keywords

  • Metal
  • Neurodegeneration
  • Parkinson's disease
  • Synuclein

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this