Adipokines: Soluble factors from adipose tissue implicated in cancer

Gilberto Paz-Filho, Ameet Kumar Mishra, Julio Licinio

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

There is strong evidence for the association between obesity and cancer. Several retrospective and prospective observational studies have demonstrated that obesity and adiposity are independent risk factors for different types of cancer in both genders. According to a recent meta-analysis, a body mass index equal of higher than 40 kg/m2 determines a relative risk for the development of all cancers equal to 1.52 for males and 1.88 for females. The adipose tissues secretes several hormones, cytokines (named adipokines), inflammatory cytokines, factors related to complement and fibrinolysis, fatty acids, and enzymes. An increase in adiposity alters the homeostasis of those substances secreted by the adipose tissue and others (such as insulin and insulin-like growth factors). The pathophysiological bases of obesity-related cancer can be explained by alterations in adipokines levels, increase in insulin resistance, changes towards a proinflammatory state, and other effects such as increased oxidative stress. Leptin and adiponectin are the most abundant adipokines, and both play a major role in the pathogenesis of obesity-related cancer. In this chapter, the role of adipokines in the pathogenesis of obesity-related cancer, with emphasis on leptin and adiponectin, is discussed.

LanguageEnglish
Title of host publicationAdipose tissue and cancer
PublisherSpringer New York
Pages71-97
Number of pages27
ISBN (Electronic)9781461476603
ISBN (Print)1461476593, 9781461476597
DOIs
Publication statusPublished - 1 Apr 2013

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paz-Filho, G., Mishra, A. K., & Licinio, J. (2013). Adipokines: Soluble factors from adipose tissue implicated in cancer. In Adipose tissue and cancer (pp. 71-97). Springer New York. https://doi.org/10.1007/978-1-4614-7660-3_5
Paz-Filho, Gilberto ; Mishra, Ameet Kumar ; Licinio, Julio. / Adipokines : Soluble factors from adipose tissue implicated in cancer. Adipose tissue and cancer. Springer New York, 2013. pp. 71-97
@inbook{612f3f8063f44c72bd6dfe7235d3084c,
title = "Adipokines: Soluble factors from adipose tissue implicated in cancer",
abstract = "There is strong evidence for the association between obesity and cancer. Several retrospective and prospective observational studies have demonstrated that obesity and adiposity are independent risk factors for different types of cancer in both genders. According to a recent meta-analysis, a body mass index equal of higher than 40 kg/m2 determines a relative risk for the development of all cancers equal to 1.52 for males and 1.88 for females. The adipose tissues secretes several hormones, cytokines (named adipokines), inflammatory cytokines, factors related to complement and fibrinolysis, fatty acids, and enzymes. An increase in adiposity alters the homeostasis of those substances secreted by the adipose tissue and others (such as insulin and insulin-like growth factors). The pathophysiological bases of obesity-related cancer can be explained by alterations in adipokines levels, increase in insulin resistance, changes towards a proinflammatory state, and other effects such as increased oxidative stress. Leptin and adiponectin are the most abundant adipokines, and both play a major role in the pathogenesis of obesity-related cancer. In this chapter, the role of adipokines in the pathogenesis of obesity-related cancer, with emphasis on leptin and adiponectin, is discussed.",
author = "Gilberto Paz-Filho and Mishra, {Ameet Kumar} and Julio Licinio",
year = "2013",
month = "4",
day = "1",
doi = "10.1007/978-1-4614-7660-3_5",
language = "English",
isbn = "1461476593",
pages = "71--97",
booktitle = "Adipose tissue and cancer",
publisher = "Springer New York",

}

Paz-Filho, G, Mishra, AK & Licinio, J 2013, Adipokines: Soluble factors from adipose tissue implicated in cancer. in Adipose tissue and cancer. Springer New York, pp. 71-97. https://doi.org/10.1007/978-1-4614-7660-3_5

Adipokines : Soluble factors from adipose tissue implicated in cancer. / Paz-Filho, Gilberto; Mishra, Ameet Kumar; Licinio, Julio.

Adipose tissue and cancer. Springer New York, 2013. p. 71-97.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Adipokines

T2 - Soluble factors from adipose tissue implicated in cancer

AU - Paz-Filho, Gilberto

AU - Mishra, Ameet Kumar

AU - Licinio, Julio

PY - 2013/4/1

Y1 - 2013/4/1

N2 - There is strong evidence for the association between obesity and cancer. Several retrospective and prospective observational studies have demonstrated that obesity and adiposity are independent risk factors for different types of cancer in both genders. According to a recent meta-analysis, a body mass index equal of higher than 40 kg/m2 determines a relative risk for the development of all cancers equal to 1.52 for males and 1.88 for females. The adipose tissues secretes several hormones, cytokines (named adipokines), inflammatory cytokines, factors related to complement and fibrinolysis, fatty acids, and enzymes. An increase in adiposity alters the homeostasis of those substances secreted by the adipose tissue and others (such as insulin and insulin-like growth factors). The pathophysiological bases of obesity-related cancer can be explained by alterations in adipokines levels, increase in insulin resistance, changes towards a proinflammatory state, and other effects such as increased oxidative stress. Leptin and adiponectin are the most abundant adipokines, and both play a major role in the pathogenesis of obesity-related cancer. In this chapter, the role of adipokines in the pathogenesis of obesity-related cancer, with emphasis on leptin and adiponectin, is discussed.

AB - There is strong evidence for the association between obesity and cancer. Several retrospective and prospective observational studies have demonstrated that obesity and adiposity are independent risk factors for different types of cancer in both genders. According to a recent meta-analysis, a body mass index equal of higher than 40 kg/m2 determines a relative risk for the development of all cancers equal to 1.52 for males and 1.88 for females. The adipose tissues secretes several hormones, cytokines (named adipokines), inflammatory cytokines, factors related to complement and fibrinolysis, fatty acids, and enzymes. An increase in adiposity alters the homeostasis of those substances secreted by the adipose tissue and others (such as insulin and insulin-like growth factors). The pathophysiological bases of obesity-related cancer can be explained by alterations in adipokines levels, increase in insulin resistance, changes towards a proinflammatory state, and other effects such as increased oxidative stress. Leptin and adiponectin are the most abundant adipokines, and both play a major role in the pathogenesis of obesity-related cancer. In this chapter, the role of adipokines in the pathogenesis of obesity-related cancer, with emphasis on leptin and adiponectin, is discussed.

UR - http://www.scopus.com/inward/record.url?scp=84922228360&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-7660-3_5

DO - 10.1007/978-1-4614-7660-3_5

M3 - Chapter

SN - 1461476593

SN - 9781461476597

SP - 71

EP - 97

BT - Adipose tissue and cancer

PB - Springer New York

ER -

Paz-Filho G, Mishra AK, Licinio J. Adipokines: Soluble factors from adipose tissue implicated in cancer. In Adipose tissue and cancer. Springer New York. 2013. p. 71-97 https://doi.org/10.1007/978-1-4614-7660-3_5