Acute high-density lipoprotein therapies

My Ngan Duong, Belinda A. Di Bartolo, Stephen J. Nicholls

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Purpose of review: Increasing interest has focused on the strategies that target the atheroprotective properties of HDL in order to reduce cardiovascular risk. The potential impact of strategies to acutely promote HDL functionality will be reviewed. Recent findings: Population and animal studies suggest that HDLs have a protective impact on atherosclerotic plaque. However, the failure of recent clinical trials of HDL cholesterol-raising agents has raised concerns that this may not be a viable strategy to reduce cardiovascular risk. Increasing attention has highlighted the importance of the functional quality, as opposed to quantity, of HDL with evidence of impaired HDL function in the setting of acute coronary syndromes (ACSs). The finding that infusing HDL in patients with recent acute ischemic events promotes the rapid regression of coronary atherosclerosis suggests a potentially useful strategy for ACS patients, although this remains to be fully established in large clinical outcome trials. Summary: Infusing HDL has favorable effects on coronary atherosclerosis in ACS patients, suggesting a potentially beneficial therapeutic strategy to acutely promote HDL functionality.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalCurrent Opinion in Lipidology
Volume26
Issue number6
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • atherosclerosis
  • clinical trials
  • high-density lipoproteins
  • lipids
  • risk factors

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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