Activity‐induced anorexia in rats does not affect hypothalamic neuropeptide gene expression chronically

Ma‐Li ‐L Wong, Júlio Licinio, Philip W. Gold, John Glowa

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Hypothalamic neuropeptides are thought to contribute to the pathophysiology of eating disorders. In an animal model with chronic abnormalities of energy expenditure, appetitive behavior, and body weight, without acute food restriction, we found alterations in peripheral levels of adrenocorticotropic hormone and corticosterone, but no alterations in the expression of neuropeptides genes that are known to regulate ingestive behavior and food intake acutely. Our data suggest that activation of hypothalamic‐pituitary‐adrenal function in activity anorexia may not be due to increased transcription of corticotropin‐releasing hormone gene, but might be related to posttranscriptional events or to other neuropeptides, such as arginine vasopressin. Furthermore, we suggest that abnormalities in neuropeptides observed in eating disorders may be caused by acute food restriction, rather than by chronic hyper‐activity, anorexia, and low weight. © 7 1993 by John Wiley & Sons, Inc.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalInternational Journal of Eating Disorders
Issue number4
Publication statusPublished - 1 Jan 1993

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this