Accuracy of fibronectin tests for the prediction of pre-eclampsia: a systematic review

M. M G Leeflang, J. S. Cnossen, J. A M van der Post, B. W J Mol, K. S. Khan, G. ter Riet

Research output: Contribution to journalReview article

16 Citations (Scopus)


The purpose of this study was to review systematically all studies that assessed the accuracy of maternal plasma fibronectin as a serum marker for early prediction of pre-eclampsia. We therefore assessed studies that reported on fibronectin as serum marker for pre-eclampsia before the 25th gestational week. For the selected studies, sensitivity and specificity were calculated and plotted in ROC-space. We included 12 studies, of which only 5 studies reported sufficient data to calculate accuracy estimates, such as sensitivity and specificity. These five studies reported on 573 pregnant women of whom 109 developed pre-eclampsia. At a sensitivity of at least 50%, specificities ranged between 72 and 96% for cellular fibronectin. For total fibronectin, these numbers were 42-94%. Fibronectin seems to be a promising marker for the prediction of pre-eclampsia, however, further studies are needed to determine whether the accuracy of this test is sufficient to be clinically relevant.

Number of pages8
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
Publication statusPublished - 1 Jan 2007


  • Fetal fibronectin
  • Fibronectin
  • Pre-eclampsia
  • Prediction
  • Sensitivity and specificity

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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