Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis

Samuel Hourigan, Anisyah Ridiandries, Edward Tepper, Jennifer Zhang, Rodney Henriquez, Tania Tsatralis, Zoë E. Clayton, Laura Z. Vanags, Stacy Robertson, S.J. Nicholls, Martin K C Ng, Christina Bursill, Joanne Tan

Research output: Contribution to journalMeeting Abstract

Abstract

Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.
LanguageEnglish
JournalCirculation
Volume136
Issue numberSuppl 1
Publication statusPublished - 14 Nov 2017

Cite this

Hourigan, S., Ridiandries, A., Tepper, E., Zhang, J., Henriquez, R., Tsatralis, T., ... Tan, J. (2017). Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. Circulation, 136(Suppl 1).