Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis

Samuel Hourigan, Anisyah Ridiandries, Edward Tepper, Jennifer Zhang, Rodney Henriquez, Tania Tsatralis, Zoë E. Clayton, Laura Z. Vanags, Stacy Robertson, S.J. Nicholls, Martin K C Ng, Christina Bursill, Joanne Tan

Research output: Contribution to journalMeeting Abstract

Abstract

Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.
LanguageEnglish
JournalCirculation
Volume136
Issue numberSuppl 1
Publication statusPublished - 14 Nov 2017

Cite this

Hourigan, S., Ridiandries, A., Tepper, E., Zhang, J., Henriquez, R., Tsatralis, T., ... Tan, J. (2017). Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. Circulation, 136(Suppl 1).
Hourigan, Samuel ; Ridiandries, Anisyah ; Tepper, Edward ; Zhang, Jennifer ; Henriquez, Rodney ; Tsatralis, Tania ; Clayton, Zoë E. ; Vanags, Laura Z. ; Robertson, Stacy ; Nicholls, S.J. ; Ng, Martin K C ; Bursill, Christina ; Tan, Joanne. / Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. In: Circulation. 2017 ; Vol. 136, No. Suppl 1.
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title = "Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis",
abstract = "Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.",
author = "Samuel Hourigan and Anisyah Ridiandries and Edward Tepper and Jennifer Zhang and Rodney Henriquez and Tania Tsatralis and Clayton, {Zo{\"e} E.} and Vanags, {Laura Z.} and Stacy Robertson and S.J. Nicholls and Ng, {Martin K C} and Christina Bursill and Joanne Tan",
year = "2017",
month = "11",
day = "14",
language = "English",
volume = "136",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "Suppl 1",

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Hourigan, S, Ridiandries, A, Tepper, E, Zhang, J, Henriquez, R, Tsatralis, T, Clayton, ZE, Vanags, LZ, Robertson, S, Nicholls, SJ, Ng, MKC, Bursill, C & Tan, J 2017, 'Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis', Circulation, vol. 136, no. Suppl 1.

Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. / Hourigan, Samuel; Ridiandries, Anisyah; Tepper, Edward; Zhang, Jennifer; Henriquez, Rodney; Tsatralis, Tania; Clayton, Zoë E.; Vanags, Laura Z.; Robertson, Stacy; Nicholls, S.J.; Ng, Martin K C; Bursill, Christina; Tan, Joanne.

In: Circulation, Vol. 136, No. Suppl 1, 14.11.2017.

Research output: Contribution to journalMeeting Abstract

TY - JOUR

T1 - Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis

AU - Hourigan, Samuel

AU - Ridiandries, Anisyah

AU - Tepper, Edward

AU - Zhang, Jennifer

AU - Henriquez, Rodney

AU - Tsatralis, Tania

AU - Clayton, Zoë E.

AU - Vanags, Laura Z.

AU - Robertson, Stacy

AU - Nicholls, S.J.

AU - Ng, Martin K C

AU - Bursill, Christina

AU - Tan, Joanne

PY - 2017/11/14

Y1 - 2017/11/14

N2 - Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.

AB - Introduction: Diabetic vascular complications are associated with impaired hypoxia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis by augmenting the classical HIF-1α/VEGFA angiogenic signalling axis, however its complete mechanism is unknown. MicroRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. We seek to determine if miRNAs are regulated by rHDL in diabetes-impaired angiogenesis.

M3 - Meeting Abstract

VL - 136

JO - Circulation

T2 - Circulation

JF - Circulation

SN - 0009-7322

IS - Suppl 1

ER -

Hourigan S, Ridiandries A, Tepper E, Zhang J, Henriquez R, Tsatralis T et al. Abstract 15013: The Regulation of miRNAs in rHDL-Induced Rescue of Diabetes-Impaired Angiogenesis. Circulation. 2017 Nov 14;136(Suppl 1).