Absence of hyaluronidase in cultured human skin fibroblasts

Bradley Arbogast, John J. Hopwood, Albert Dorfman

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The in vitro degradation of [35S]chondroitin sulfate was investigated in human fibroblasts and rat liver. In rat liver, preparations of chondroitin sulfate were shown to be degraded by the concerted action of endoglycosidase and exoglycosidases. However, with human skin fibroblast preparations, hyaluronidase activity was not detected and chondroitin sulfate was degraded by exoglycosidase action.

Original languageEnglish
Pages (from-to)376-382
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished or Issued - 3 Nov 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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