A xylazine infusion regimen to provide analgesia in sheep

C. Grant, G. E. Summersides, T. R. Kuchel

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The efficacy of continuous low-dose xylazine infusion following an initial loading dose in providing analgesia in sheep was examined using an algesimetry method based on a leg lifting response to an electrical stimulus. Sheep received a 5 mg intramuscular injection of xylazine followed by continuous infusion of intravenous xylazine (2 mg/h) for 90 min. This treatment resulted in significant increases in the level of current required to elicit a leg lifting response (287% of baseline) and steady state analgesia was maintained from 10 min after the start of the infusion until the end of the experimental period. This protocol appears to be a simple and effective regimen for providing steady state analgesia in sheep.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalLaboratory Animals
Issue number3
Publication statusPublished - 1 Jan 2001


  • Algesimetry
  • Analgesia
  • Nociception
  • Sheep
  • Xylazine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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