A sheep preparation for studying interactions between blood flow and drug disposition: Iv: The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition

W. B. Runciman, L. E. Mather, A. H. Ilsley, R. J. Carapetis, R. N. Upton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Control measurements of bloodflow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steadystate conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to approximately 74) subarachnoid blockade with amethocaine. In the control-drug studies, it was shown that cefoxitin was cleared by the kidneys and that the cefoxitin infusion produced no significant changes in haemodynamics or in the kinetics of iodohippurate (the marker substance used for determining renal blood flow). Under general anaesthesia, there were significant reductions in renal blood flow (to 61% of the mean control value), in iodohippurate renal extraction ratio and clearance (to, respectively, 64 and 38% of the mean control values) and in cefoxitin renal extraction ratio and clearance (to, respectively, 48 and 23% of the mean control values). Under spinal anaesthesia there were no significant changes in haemodynamics or in cefoxitin or iodohippurate extraction ratios or clearances.

LanguageEnglish
Pages1239-1247
Number of pages9
JournalBritish Journal of Anaesthesia
Volume57
Issue number12
DOIs
Publication statusPublished - 1 Jan 1985
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

@article{22b1d6366fd84f7690d1410aae1a3554,
title = "A sheep preparation for studying interactions between blood flow and drug disposition: Iv: The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition",
abstract = "Control measurements of bloodflow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steadystate conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5{\%} halothane or whilst undergoing high thoracic (to approximately 74) subarachnoid blockade with amethocaine. In the control-drug studies, it was shown that cefoxitin was cleared by the kidneys and that the cefoxitin infusion produced no significant changes in haemodynamics or in the kinetics of iodohippurate (the marker substance used for determining renal blood flow). Under general anaesthesia, there were significant reductions in renal blood flow (to 61{\%} of the mean control value), in iodohippurate renal extraction ratio and clearance (to, respectively, 64 and 38{\%} of the mean control values) and in cefoxitin renal extraction ratio and clearance (to, respectively, 48 and 23{\%} of the mean control values). Under spinal anaesthesia there were no significant changes in haemodynamics or in cefoxitin or iodohippurate extraction ratios or clearances.",
author = "Runciman, {W. B.} and Mather, {L. E.} and Ilsley, {A. H.} and Carapetis, {R. J.} and Upton, {R. N.}",
year = "1985",
month = "1",
day = "1",
doi = "10.1093/bja/57.12.1239",
language = "English",
volume = "57",
pages = "1239--1247",
journal = "British Journal of Anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "12",

}

A sheep preparation for studying interactions between blood flow and drug disposition : Iv: The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition. / Runciman, W. B.; Mather, L. E.; Ilsley, A. H.; Carapetis, R. J.; Upton, R. N.

In: British Journal of Anaesthesia, Vol. 57, No. 12, 01.01.1985, p. 1239-1247.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A sheep preparation for studying interactions between blood flow and drug disposition

T2 - British Journal of Anaesthesia

AU - Runciman, W. B.

AU - Mather, L. E.

AU - Ilsley, A. H.

AU - Carapetis, R. J.

AU - Upton, R. N.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Control measurements of bloodflow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steadystate conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to approximately 74) subarachnoid blockade with amethocaine. In the control-drug studies, it was shown that cefoxitin was cleared by the kidneys and that the cefoxitin infusion produced no significant changes in haemodynamics or in the kinetics of iodohippurate (the marker substance used for determining renal blood flow). Under general anaesthesia, there were significant reductions in renal blood flow (to 61% of the mean control value), in iodohippurate renal extraction ratio and clearance (to, respectively, 64 and 38% of the mean control values) and in cefoxitin renal extraction ratio and clearance (to, respectively, 48 and 23% of the mean control values). Under spinal anaesthesia there were no significant changes in haemodynamics or in cefoxitin or iodohippurate extraction ratios or clearances.

AB - Control measurements of bloodflow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steadystate conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to approximately 74) subarachnoid blockade with amethocaine. In the control-drug studies, it was shown that cefoxitin was cleared by the kidneys and that the cefoxitin infusion produced no significant changes in haemodynamics or in the kinetics of iodohippurate (the marker substance used for determining renal blood flow). Under general anaesthesia, there were significant reductions in renal blood flow (to 61% of the mean control value), in iodohippurate renal extraction ratio and clearance (to, respectively, 64 and 38% of the mean control values) and in cefoxitin renal extraction ratio and clearance (to, respectively, 48 and 23% of the mean control values). Under spinal anaesthesia there were no significant changes in haemodynamics or in cefoxitin or iodohippurate extraction ratios or clearances.

UR - http://www.scopus.com/inward/record.url?scp=0022413578&partnerID=8YFLogxK

U2 - 10.1093/bja/57.12.1239

DO - 10.1093/bja/57.12.1239

M3 - Article

VL - 57

SP - 1239

EP - 1247

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 12

ER -