A revised prediction model for natural conception

Alexandra J. Bensdorp, Jan Willem van der Steeg, Pieternel Steures, J. Dik F. Habbema, Peter G.A. Hompes, Patrick M.M. Bossuyt, Fulco van der Veen, Ben W.J. Mol, Marinus J.C. Eijkemans, Y. M. van Kasteren, P. F.M. van der Heijden, W. A. Schöls, M. H. Mochtar, G. L.M. Lips, J. Dawson, H. R. Verhoeve, S. Milosavljevic, P. G.A. Hompes, L. J. van Dam, A. V. Sluijmer & 28 others H. E. Bobeck, R. E. Bernardus, M. C.S. Vermeer, J. P. Dörr, P. J.Q. van der Linden, H. J.M. Roelofs, J. M. Burggraaff, G. J.E. Oosterhuis, M. H. Schouwink, P. X.J.M. Bouckaert, F. M.C. Delemarre, C. J.C.M. Hamilton, M. van Hoven, M. H. Emanuel, C. N.M. Renckens, J. A. Land, J. H. Schagen-Van Leeuwen, J. A.M. Kremer, C. van Katwijk, M. H.A. van Hooff, H. J.H.M. Van Dessel, F. J.M. Broekmans, H. J.L.A. Ruis, C. A.M. Koks, P. Bourdrez, W. W.J. Riedijk, B. J. Cohlen, CECERM study group

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

One of the aims in reproductive medicine is to differentiate between couples that have favourable chances of conceiving naturally and those that do not. Since the development of the prediction model of Hunault, characteristics of the subfertile population have changed. The objective of this analysis was to assess whether additional predictors can refine the Hunault model and extend its applicability. Consecutive subfertile couples with unexplained and mild male subfertility presenting in fertility clinics were asked to participate in a prospective cohort study. We constructed a multivariable prediction model with the predictors from the Hunault model and new potential predictors. The primary outcome, natural conception leading to an ongoing pregnancy, was observed in 1053 women of the 5184 included couples (20%). All predictors of the Hunault model were selected into the revised model plus an additional seven (woman's body mass index, cycle length, basal FSH levels, tubal status,history of previous pregnancies in the current relationship (ongoing pregnancies after natural conception, fertility treatment or miscarriages), semen volume, and semen morphology. Predictions from the revised model seem to concur better with observed pregnancy rates compared with the Hunault model; c-statistic of 0.71 (95% CI 0.69 to 0.73) compared with 0.59 (95% CI 0.57 to 0.61).

LanguageEnglish
Pages619-626
Number of pages8
JournalReproductive BioMedicine Online
Volume34
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Natural conception
  • Prediction model
  • Prognosis
  • Subfertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

Cite this

Bensdorp, A. J., van der Steeg, J. W., Steures, P., Habbema, J. D. F., Hompes, P. G. A., Bossuyt, P. M. M., ... CECERM study group (2017). A revised prediction model for natural conception. Reproductive BioMedicine Online, 34(6), 619-626. https://doi.org/10.1016/j.rbmo.2017.03.014
Bensdorp, Alexandra J. ; van der Steeg, Jan Willem ; Steures, Pieternel ; Habbema, J. Dik F. ; Hompes, Peter G.A. ; Bossuyt, Patrick M.M. ; van der Veen, Fulco ; Mol, Ben W.J. ; Eijkemans, Marinus J.C. ; van Kasteren, Y. M. ; van der Heijden, P. F.M. ; Schöls, W. A. ; Mochtar, M. H. ; Lips, G. L.M. ; Dawson, J. ; Verhoeve, H. R. ; Milosavljevic, S. ; Hompes, P. G.A. ; van Dam, L. J. ; Sluijmer, A. V. ; Bobeck, H. E. ; Bernardus, R. E. ; Vermeer, M. C.S. ; Dörr, J. P. ; van der Linden, P. J.Q. ; Roelofs, H. J.M. ; Burggraaff, J. M. ; Oosterhuis, G. J.E. ; Schouwink, M. H. ; Bouckaert, P. X.J.M. ; Delemarre, F. M.C. ; Hamilton, C. J.C.M. ; van Hoven, M. ; Emanuel, M. H. ; Renckens, C. N.M. ; Land, J. A. ; Schagen-Van Leeuwen, J. H. ; Kremer, J. A.M. ; van Katwijk, C. ; van Hooff, M. H.A. ; Van Dessel, H. J.H.M. ; Broekmans, F. J.M. ; Ruis, H. J.L.A. ; Koks, C. A.M. ; Bourdrez, P. ; Riedijk, W. W.J. ; Cohlen, B. J. ; CECERM study group. / A revised prediction model for natural conception. In: Reproductive BioMedicine Online. 2017 ; Vol. 34, No. 6. pp. 619-626.
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Bensdorp, AJ, van der Steeg, JW, Steures, P, Habbema, JDF, Hompes, PGA, Bossuyt, PMM, van der Veen, F, Mol, BWJ, Eijkemans, MJC, van Kasteren, YM, van der Heijden, PFM, Schöls, WA, Mochtar, MH, Lips, GLM, Dawson, J, Verhoeve, HR, Milosavljevic, S, Hompes, PGA, van Dam, LJ, Sluijmer, AV, Bobeck, HE, Bernardus, RE, Vermeer, MCS, Dörr, JP, van der Linden, PJQ, Roelofs, HJM, Burggraaff, JM, Oosterhuis, GJE, Schouwink, MH, Bouckaert, PXJM, Delemarre, FMC, Hamilton, CJCM, van Hoven, M, Emanuel, MH, Renckens, CNM, Land, JA, Schagen-Van Leeuwen, JH, Kremer, JAM, van Katwijk, C, van Hooff, MHA, Van Dessel, HJHM, Broekmans, FJM, Ruis, HJLA, Koks, CAM, Bourdrez, P, Riedijk, WWJ, Cohlen, BJ & CECERM study group 2017, 'A revised prediction model for natural conception', Reproductive BioMedicine Online, vol. 34, no. 6, pp. 619-626. https://doi.org/10.1016/j.rbmo.2017.03.014

A revised prediction model for natural conception. / Bensdorp, Alexandra J.; van der Steeg, Jan Willem; Steures, Pieternel; Habbema, J. Dik F.; Hompes, Peter G.A.; Bossuyt, Patrick M.M.; van der Veen, Fulco; Mol, Ben W.J.; Eijkemans, Marinus J.C.; van Kasteren, Y. M.; van der Heijden, P. F.M.; Schöls, W. A.; Mochtar, M. H.; Lips, G. L.M.; Dawson, J.; Verhoeve, H. R.; Milosavljevic, S.; Hompes, P. G.A.; van Dam, L. J.; Sluijmer, A. V.; Bobeck, H. E.; Bernardus, R. E.; Vermeer, M. C.S.; Dörr, J. P.; van der Linden, P. J.Q.; Roelofs, H. J.M.; Burggraaff, J. M.; Oosterhuis, G. J.E.; Schouwink, M. H.; Bouckaert, P. X.J.M.; Delemarre, F. M.C.; Hamilton, C. J.C.M.; van Hoven, M.; Emanuel, M. H.; Renckens, C. N.M.; Land, J. A.; Schagen-Van Leeuwen, J. H.; Kremer, J. A.M.; van Katwijk, C.; van Hooff, M. H.A.; Van Dessel, H. J.H.M.; Broekmans, F. J.M.; Ruis, H. J.L.A.; Koks, C. A.M.; Bourdrez, P.; Riedijk, W. W.J.; Cohlen, B. J.; CECERM study group.

In: Reproductive BioMedicine Online, Vol. 34, No. 6, 01.06.2017, p. 619-626.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A revised prediction model for natural conception

AU - Bensdorp, Alexandra J.

AU - van der Steeg, Jan Willem

AU - Steures, Pieternel

AU - Habbema, J. Dik F.

AU - Hompes, Peter G.A.

AU - Bossuyt, Patrick M.M.

AU - van der Veen, Fulco

AU - Mol, Ben W.J.

AU - Eijkemans, Marinus J.C.

AU - van Kasteren, Y. M.

AU - van der Heijden, P. F.M.

AU - Schöls, W. A.

AU - Mochtar, M. H.

AU - Lips, G. L.M.

AU - Dawson, J.

AU - Verhoeve, H. R.

AU - Milosavljevic, S.

AU - Hompes, P. G.A.

AU - van Dam, L. J.

AU - Sluijmer, A. V.

AU - Bobeck, H. E.

AU - Bernardus, R. E.

AU - Vermeer, M. C.S.

AU - Dörr, J. P.

AU - van der Linden, P. J.Q.

AU - Roelofs, H. J.M.

AU - Burggraaff, J. M.

AU - Oosterhuis, G. J.E.

AU - Schouwink, M. H.

AU - Bouckaert, P. X.J.M.

AU - Delemarre, F. M.C.

AU - Hamilton, C. J.C.M.

AU - van Hoven, M.

AU - Emanuel, M. H.

AU - Renckens, C. N.M.

AU - Land, J. A.

AU - Schagen-Van Leeuwen, J. H.

AU - Kremer, J. A.M.

AU - van Katwijk, C.

AU - van Hooff, M. H.A.

AU - Van Dessel, H. J.H.M.

AU - Broekmans, F. J.M.

AU - Ruis, H. J.L.A.

AU - Koks, C. A.M.

AU - Bourdrez, P.

AU - Riedijk, W. W.J.

AU - Cohlen, B. J.

AU - CECERM study group

PY - 2017/6/1

Y1 - 2017/6/1

N2 - One of the aims in reproductive medicine is to differentiate between couples that have favourable chances of conceiving naturally and those that do not. Since the development of the prediction model of Hunault, characteristics of the subfertile population have changed. The objective of this analysis was to assess whether additional predictors can refine the Hunault model and extend its applicability. Consecutive subfertile couples with unexplained and mild male subfertility presenting in fertility clinics were asked to participate in a prospective cohort study. We constructed a multivariable prediction model with the predictors from the Hunault model and new potential predictors. The primary outcome, natural conception leading to an ongoing pregnancy, was observed in 1053 women of the 5184 included couples (20%). All predictors of the Hunault model were selected into the revised model plus an additional seven (woman's body mass index, cycle length, basal FSH levels, tubal status,history of previous pregnancies in the current relationship (ongoing pregnancies after natural conception, fertility treatment or miscarriages), semen volume, and semen morphology. Predictions from the revised model seem to concur better with observed pregnancy rates compared with the Hunault model; c-statistic of 0.71 (95% CI 0.69 to 0.73) compared with 0.59 (95% CI 0.57 to 0.61).

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KW - Prognosis

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Bensdorp AJ, van der Steeg JW, Steures P, Habbema JDF, Hompes PGA, Bossuyt PMM et al. A revised prediction model for natural conception. Reproductive BioMedicine Online. 2017 Jun 1;34(6):619-626. https://doi.org/10.1016/j.rbmo.2017.03.014