A novel serine protease overexpressed in the hair follicles of nude mice

N. Meier, Terence Neil Dear, T. Boehm

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We have studied changes in gene expression between normal and nude mouse skin. Using the method of representational difference analysis, a cDNA encoding a novel serine protease designated BSSP was cloned. Our results show that in skin this gene is predominantly expressed in the sebaceous gland of the hair follicle and in the distal part of the outer root sheath. Thus, BSSP is the first serine protease known to be expressed in the sebaceous gland. In nude mouse skin, this gene is overexpressed.

LanguageEnglish
Pages374-378
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume258
Issue number2
DOIs
Publication statusPublished - 10 May 1999

Keywords

  • Hair follicle
  • Nude mouse
  • Overexpression
  • Sebaceous gland
  • Serine protease

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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