A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

Iain Comerford, Yuka Harata-Lee, Mark D Bunting, Carly Gregor, Ervin E Kara, Shaun R McColl

Research output: Contribution to journalReview article

93 Citations (Scopus)

Abstract

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.

LanguageEnglish
Pages269-83
Number of pages15
JournalCytokine and Growth Factor Reviews
Volume24
Issue number3
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Keywords

  • Adaptive Immunity/immunology
  • Animals
  • Chemokine CCL19/biosynthesis
  • Chemokine CCL21/biosynthesis
  • Dendritic Cells/immunology
  • Humans
  • Receptors, CCR/biosynthesis
  • Receptors, CCR7/physiology
  • T-Lymphocytes, Regulatory/immunology
  • Thymus Gland/embryology

Cite this

Comerford, Iain ; Harata-Lee, Yuka ; Bunting, Mark D ; Gregor, Carly ; Kara, Ervin E ; McColl, Shaun R. / A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system. In: Cytokine and Growth Factor Reviews. 2013 ; Vol. 24, No. 3. pp. 269-83.
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abstract = "The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.",
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A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system. / Comerford, Iain; Harata-Lee, Yuka; Bunting, Mark D; Gregor, Carly; Kara, Ervin E; McColl, Shaun R.

In: Cytokine and Growth Factor Reviews, Vol. 24, No. 3, 06.2013, p. 269-83.

Research output: Contribution to journalReview article

TY - JOUR

T1 - A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

AU - Comerford, Iain

AU - Harata-Lee, Yuka

AU - Bunting, Mark D

AU - Gregor, Carly

AU - Kara, Ervin E

AU - McColl, Shaun R

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/6

Y1 - 2013/6

N2 - The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.

AB - The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.

KW - Adaptive Immunity/immunology

KW - Animals

KW - Chemokine CCL19/biosynthesis

KW - Chemokine CCL21/biosynthesis

KW - Dendritic Cells/immunology

KW - Humans

KW - Receptors, CCR/biosynthesis

KW - Receptors, CCR7/physiology

KW - T-Lymphocytes, Regulatory/immunology

KW - Thymus Gland/embryology

U2 - 10.1016/j.cytogfr.2013.03.001

DO - 10.1016/j.cytogfr.2013.03.001

M3 - Review article

VL - 24

SP - 269

EP - 283

JO - Cytokine and Growth Factor Reviews

T2 - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

IS - 3

ER -