A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system

Iain Comerford, Yuka Harata-Lee, Mark D Bunting, Carly Gregor, Ervin E Kara, Shaun R McColl

Research output: Contribution to journalReview article

104 Citations (Scopus)

Abstract

The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs. However, CCR7 and its ligands also contribute to a multitude of adaptive immune functions including thymocyte development, secondary lymphoid organogenesis, high affinity antibody responses, regulatory and memory T cell function, and lymphocyte egress from tissues. In this survey, we summarise the role of CCR7 in adaptive immunity and describe recent progress in understanding how this axis is regulated. In particular we highlight CCX-CKR, which scavenges both CCR7 ligands, and discuss its emerging significance in the immune system.

Original languageEnglish
Pages (from-to)269-83
Number of pages15
JournalCytokine and Growth Factor Reviews
Volume24
Issue number3
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Keywords

  • Adaptive Immunity/immunology
  • Animals
  • Chemokine CCL19/biosynthesis
  • Chemokine CCL21/biosynthesis
  • Dendritic Cells/immunology
  • Humans
  • Receptors, CCR/biosynthesis
  • Receptors, CCR7/physiology
  • T-Lymphocytes, Regulatory/immunology
  • Thymus Gland/embryology

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