A genomics approach to the detection of positive selection in cattle: Adaptive evolution of the T-cell and natural killer cell-surface protein CD2

David J. Lynn, Abigail R. Freeman, Caitriona Murray, Daniel G. Bradley

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an important domestic species. This analysis led to the identification of the T-cell and natural killer (NK) cell receptor cluster of differentiation 2 (CD2) as having a strong signal of selection. Further detailed investigation of CD2 revealed that this gene was subject to positive selection during the evolution of a number of mammalian lineages. Moreover, we show that selection has operated primarily on the extracellular domain of CD2 and discuss the implications of this for an important regulator of the adaptive immune response.

Original languageEnglish
Pages (from-to)1189-1196
Number of pages8
JournalGenetics
Volume170
Issue number3
DOIs
Publication statusPublished - 1 Jul 2005

ASJC Scopus subject areas

  • Genetics

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