{A figure is presented}Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides

Tanya J. Little, Antonietta Russo, James H. Meyer, Michael Horowitz, Douglas Smyth, Max Bellon, Judith M. Wishart, Karen L. Jones, Christine Feinle-Bisset

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Background & Aims: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males. Methods: Nine men (age, 23 ± 2 y; body mass index, 22 ± 1 kg/m2) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4% milk protein and labeled with 15 MBq 123I), or (3) 600 mL 4% milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake. Results: GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 ± 610 kJ; TG, 5463 ± 662 kJ; FFA, 4199 ± 410 kJ). Conclusions: FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.

LanguageEnglish
Pages1124-1131
Number of pages8
JournalGastroenterology
Volume133
Issue number4
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Little, Tanya J. ; Russo, Antonietta ; Meyer, James H. ; Horowitz, Michael ; Smyth, Douglas ; Bellon, Max ; Wishart, Judith M. ; Jones, Karen L. ; Feinle-Bisset, Christine. / {A figure is presented}Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides. In: Gastroenterology. 2007 ; Vol. 133, No. 4. pp. 1124-1131.
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title = "{A figure is presented}Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides",
abstract = "Background & Aims: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males. Methods: Nine men (age, 23 ± 2 y; body mass index, 22 ± 1 kg/m2) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4{\%} milk protein and labeled with 15 MBq 123I), or (3) 600 mL 4{\%} milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake. Results: GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 ± 610 kJ; TG, 5463 ± 662 kJ; FFA, 4199 ± 410 kJ). Conclusions: FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.",
author = "Little, {Tanya J.} and Antonietta Russo and Meyer, {James H.} and Michael Horowitz and Douglas Smyth and Max Bellon and Wishart, {Judith M.} and Jones, {Karen L.} and Christine Feinle-Bisset",
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Little, TJ, Russo, A, Meyer, JH, Horowitz, M, Smyth, D, Bellon, M, Wishart, JM, Jones, KL & Feinle-Bisset, C 2007, '{A figure is presented}Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides', Gastroenterology, vol. 133, no. 4, pp. 1124-1131. https://doi.org/10.1053/j.gastro.2007.06.060

{A figure is presented}Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides. / Little, Tanya J.; Russo, Antonietta; Meyer, James H.; Horowitz, Michael; Smyth, Douglas; Bellon, Max; Wishart, Judith M.; Jones, Karen L.; Feinle-Bisset, Christine.

In: Gastroenterology, Vol. 133, No. 4, 10.2007, p. 1124-1131.

Research output: Contribution to journalArticle

TY - JOUR

T1 - {A figure is presented}Free Fatty Acids Have More Potent Effects on Gastric Emptying, Gut Hormones, and Appetite Than Triacylglycerides

AU - Little, Tanya J.

AU - Russo, Antonietta

AU - Meyer, James H.

AU - Horowitz, Michael

AU - Smyth, Douglas

AU - Bellon, Max

AU - Wishart, Judith M.

AU - Jones, Karen L.

AU - Feinle-Bisset, Christine

PY - 2007/10

Y1 - 2007/10

N2 - Background & Aims: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males. Methods: Nine men (age, 23 ± 2 y; body mass index, 22 ± 1 kg/m2) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4% milk protein and labeled with 15 MBq 123I), or (3) 600 mL 4% milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake. Results: GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 ± 610 kJ; TG, 5463 ± 662 kJ; FFA, 4199 ± 410 kJ). Conclusions: FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.

AB - Background & Aims: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males. Methods: Nine men (age, 23 ± 2 y; body mass index, 22 ± 1 kg/m2) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4% milk protein and labeled with 15 MBq 123I), or (3) 600 mL 4% milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake. Results: GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 ± 610 kJ; TG, 5463 ± 662 kJ; FFA, 4199 ± 410 kJ). Conclusions: FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.

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U2 - 10.1053/j.gastro.2007.06.060

DO - 10.1053/j.gastro.2007.06.060

M3 - Article

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SP - 1124

EP - 1131

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T2 - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

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