A case of inflammatory myopathy in graft vs host disease - A potential role for ibrutinib

Michael Wilkinson, David Yeung, Vidya Limaye

Research output: Contribution to journalArticlepeer-review

Abstract

Myositis is a known complication of chronic graft-vs-host disease (cGVHD) following allogeneic haematopoietic stem cell transplantation, but can be difficult to diagnose and manage. We present the case of a 57 year old man with cGVHD in whom the full manifestations of myositis were suppressed for some time, likely due to partial treatment of his condition with immunosuppression including ibrutinib. Though initial muscle biopsy showed necrotising myopathy without significant inflammation, on cessation of ibrutinib he developed increasing weakness and creatine kinase levels, with repeat muscle biopsy showing histological changes more in keeping with dermatomyositis. The close temporal correlation of his clinical course with commencement and cessation of ibrutinib suggests a potential role for ibrutinib in treating inflammatory myopathy in cGVHD.

Original languageEnglish
Pages (from-to)865-869
Number of pages5
JournalNeuromuscular Disorders
Volume31
Issue number9
DOIs
Publication statusPublished or Issued - Sep 2021
Externally publishedYes

Keywords

  • Dermatomyositis
  • Graft versus host disease
  • Ibrutinib
  • Muscle biopsy
  • Necrotising myopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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