A biomimetic synthetic approach to the frondosins

Kevin K.W. Kuan, Aylin M.C. Hirschvogel, Jonathan H. George

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The frondosins are a family of five marine sponge-derived meroterpenoids. We propose that the 6-7 ring system common to each of the frondosins is biosynthesized via ring expansion of a 6-6 ring system. Compelling evidence in favour of this proposal was obtained in the form of a biomimetic synthesis of the frondosin 6-7 ring system, which features a highly stereo- and regio-selective ring expansion cascade reaction as the key step.

Original languageEnglish
Pages (from-to)1420-1423
Number of pages4
JournalAustralian Journal of Chemistry
Issue number12
Publication statusPublished or Issued - 2016

ASJC Scopus subject areas

  • Chemistry(all)

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