25-Hydroxyvitamin D levels in prevalent Australian dialysis patients

Philip Clayton, Richard Singer

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Aim:Vitamin D deficiency is a common problem in the general population. A high frequency of vitamin D deficiency in the pre-dialysis and dialysis populations has been observed overseas, but there is limited information regarding vitamin D levels in Australian dialysis patients. Method: We measured 25-hydroxyvitamin D levels in 120 haemodialysis (HD) and 31 peritoneal dialysis (PD) patients. We defined vitamin D deficiency as a level <50 nmol/L and insufficiency as a level of 50-74 nmol/L. We assessed for correlation between vitamin D levels and markers of bone and mineral metabolism, age, sex, dialysis type, dialysis duration, haemoglobin and erythropoietin dose. Results: Of the HD patients, 59 (49%) were frankly deficient and 39 (33%) had insufficiency. Of the PD patients, 24 (77%) were frankly deficient and 6 (19%) had insufficiency. Overall, only 23 patients (19%) had sufficient levels of vitamin D. Vitamin D levels were significantly lower in PD patients (P = 0.001), in females (P = 0.002) and in those with diabetic nephropathy (P = 0.03). There was no correlation between vitamin D levels and markers of bone and mineral metabolism, age, dialysis duration, haemoglobin or erythropoietin dose. Conclusion: Vitamin D deficiency and insufficiency were very common in this cohort of prevalent Australian dialysis patients. Lower levels were associated with PD as treatment modality, female sex and diabetic nephropathy.

Original languageEnglish
Pages (from-to)554-559
Number of pages6
JournalNephrology
Volume14
Issue number6
DOIs
Publication statusPublished or Issued - 1 Sep 2009
Externally publishedYes

Keywords

  • Deficiency
  • Nutrition
  • Peritoneal dialysis
  • Renal dialysis
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology

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