[166Dy]dysprosium/[166Ho]holmium in vivo generator

S V Smith, N Di Bartolo, S Mirzadeh, R M Lambrecht, F F Knapp, E L Hetherington

Research output: Contribution to journalArticlepeer-review

Abstract

A novel approach for the delivery of 166Ho (t1/2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo 166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to beta- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (+/- 7%) over a 20 h period, indicating no significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results.

Original languageEnglish
Pages (from-to)759-64
Number of pages6
JournalApplied Radiation and Isotopes
Volume46
Issue number8
DOIs
Publication statusPublished or Issued - Aug 1995
Externally publishedYes

Keywords

  • Animals
  • Bone Marrow/metabolism
  • Bone and Bones/metabolism
  • Dysprosium/pharmacokinetics
  • Holmium/pharmacokinetics
  • Humans
  • Kinetics
  • Mice
  • Mice, Inbred BALB C
  • Organometallic Compounds/pharmacokinetics
  • Pentetic Acid/analogs & derivatives
  • Radioisotopes/pharmacokinetics
  • Serum Albumin/pharmacokinetics
  • Tissue Distribution

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