• 3985 Citations
  • 35 h-Index
1993 …2019
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Personal profile

Public Profile

Experience:

International experience of biomedical research in world-leading Universities and Research Institutes in the UK, Canada and Australia.

I have led many research projects into the regulation of gene expression and the molecular basis of human disease, involving many international collaborations and coordinating projects with China.

I have trained over 60 Masters and PhD students and junior postdoctoral researchers.

Publications:

I have co-authored about 60 papers; >5000 citations; h-index = 36.

Expertise:

My research focuses on the mechanisms that control cell function and their roles in human diseases, in particular, the intracellular signalling pathways that control protein synthesis in mammalian cells.

Areas of current interest include the mammalian target of rapamycin (mTOR) pathway which integrates signals from nutrients and hormones such as insulin. In turn, mTOR controls a host of cellular processes, including protein and lipid synthesis. Defects in the control of mTOR can lead to human diseases such as cancer, type 2 diabetes, neurological disorders and cardiovascular disease.

My research at SAHMRI includes studies on the regulation of protein synthesis in cancer cells, especially in tumour growth, and on the molecular mechanisms that drive diet-induced weight gain and the development of metabolic diseases such as type 2 diabetes. A key goal is to identify novel therapeutic targets to tackle these widespread and often hard-to-treat disorders.

I belong to the Australian Neuroscience Society and the Biochemical Society and am an Associate Member of the Faculty of 1000.

Education/Academic qualification

PhD, University of Bristol

PhD, Beijing (Peking) Medical College

External positions

Associate Professor, Molecular & Biomedical Science, University of Adelaide

Aug 2014 → …

Visiting Professor, Ocean University of China

2009 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1993 2019

  • 3985 Citations
  • 35 h-Index
  • 47 Article
  • 7 Review article
  • 2 Chapter
  • 2 Comment/debate
1 Citation (Scopus)

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

Xie, J., de Souza Alves, V., von der Haar, T., O'Keefe, L., Lenchine, R. V., Jensen, K. B., Liu, R., Coldwell, M. J., Wang, X. & Proud, C. G., 4 Feb 2019, In : Current Biology. 29, 5

Research output: Contribution to journalArticle

5 Citations (Scopus)

Eukaryotic elongation factor 2 kinase upregulates the expression of proteins implicated in cell migration and cancer cell metastasis

Xie, J., Shen, K., Lenchine, R. V., Gethings, L. A., Trim, P. J., Snel, M. F., Zhou, Y., Kenney, J. W., Kamei, M., Kochetkova, M., Wang, X. & Proud, C. G., 1 May 2018, In : International Journal of Cancer. 142, 9, p. 1865-1877 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Non-high-density lipoprotein cholesterol is more informative than traditional cholesterol indices in predicting diabetes risk for women with normal glucose tolerance

Liu, L., Li, Q., Yuan, Z., Zhao, M., Zhang, X., Zhang, H., Zheng, D., Xu, J., Gao, L., Guan, Q., Zhao, J., Proud, C. G., Wang, X., Hou, X. & REACTION Study Group, Nov 2018, In : Journal of Diabetes Investigation. 9, 6, p. 1304-1311 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Who does TORC2 talk to?

Xie, J., Wang, X. & Proud, C. G., 24 May 2018, In : Biochemical Journal. 475, 10, p. 1721-1738 18 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2

Li, Y., Song, Y., Zhao, M., Guo, Y., Yu, C., Chen, W., Shao, S., Xu, C., Zhou, X., Zhao, L., Zhang, Z., Bo, T., Xia, Y., Proud, C. G., Wang, X., Wang, L., Zhao, J. & Gao, L., 1 Aug 2017, In : Hepatology. 66, 2, p. 481-497 17 p.

Research output: Contribution to journalArticle