Xuemin Wang

Associate Professor

  • 4252 Citations
  • 35 h-Index
1993 …2020

Research output per year

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Personal profile

Public Profile

Experience:

International experience of biomedical research in world-leading Universities and Research Institutes in the UK, Canada and Australia.

I have led many research projects into the regulation of gene expression and the molecular basis of human disease, involving many international collaborations and coordinating biomedical research projects with China.

I have trained over 60 Masters and PhD students and junior postdoctoral researchers.

Publications:

I have co-authored > 60 papers; >6000 citations; h-index = 37.

Expertise:

My research focuses on the mechanisms that control cell function and their roles in human diseases, in particular, the intracellular signalling pathways that control protein synthesis in mammalian cells.

Areas of current interest include the mammalian target of rapamycin (mTOR) pathway which integrates signals from nutrients and hormones such as insulin. In turn, mTOR controls a host of cellular processes, including protein and lipid synthesis. Defects in the control of mTOR can lead to human diseases such as cancer, type 2 diabetes, neurological disorders and cardiovascular disease.

My research at SAHMRI includes studies on the regulation of protein synthesis in cancer cells, especially in tumour growth, and on the molecular mechanisms that drive diet-induced weight gain and the development of metabolic diseases such as type 2 diabetes. A key goal is to identify novel therapeutic targets to tackle these widespread and often hard-to-treat disorders.

I belong to the Australian Neuroscience Society and the Biochemical Society and am an Associate Member of the Faculty of 1000.

Education/Academic qualification

PhD, University of Bristol

PhD, Beijing (Peking) Medical College

External positions

Visiting Professor, Qingdao University

2019 → …

Associate Professor, Molecular & Biomedical Science, University of Adelaide

Aug 2014 → …

Visiting Professor, Ocean University of China

2009 → …

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Research Output

  • 4252 Citations
  • 35 h-Index
  • 51 Article
  • 7 Review article
  • 2 Chapter
  • 2 Comment/debate

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K., Trim, P., Snel, M., Kamei, M., Martin, S., Fitter, S., Tian, S., Wang, X. & 3 others, Butler, L., Zannettino, A. & Proud, C., 1 Jan 2020, In : Cellular and Molecular Life Sciences.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2

Xiao, M., Xie, J., Wu, Y., Wang, G., Qi, X., Liu, Z., Wang, Y., Wang, X., Hoque, A., Oakhill, J., Proud, C. G. & Li, J., 13 Feb 2020, In : Cell Communication and Signaling. 18, 1, 25.

Research output: Contribution to journalArticle

The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis

Jin, X., Xie, J., Zabolocki, M., Wang, X., Jiang, T., Wang, D., Desaubry, L., Bardy, C. & Proud, C. G., 19 May 2020, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

Xie, J., de Souza Alves, V., von der Haar, T., O'Keefe, L., Lenchine, R. V., Jensen, K. B., Liu, R., Coldwell, M. J., Wang, X. & Proud, C. G., 4 Feb 2019, In : Current Biology. 29, 5

Research output: Contribution to journalArticle

6 Citations (Scopus)

Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation

Charitou, T., Srihari, S., Lynn, M. A., Jarboui, M. A., Fasterius, E., Moldovan, M., Shirasawa, S., Tsunoda, T., Ueffing, M., Xie, J., Xin, J., Wang, X., Proud, C. G., Boldt, K., Al-Khalili Szigyarto, C., Kolch, W. & Lynn, D. J., 2 Jul 2019, In : British Journal of Cancer. 121, 1, p. 37-50 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)