Ville-Petteri Makinen

Associate Professor

  • 2102 Citations
  • 25 h-Index
20052019
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Personal profile

Public Profile

Ville-Petteri Mäkinen's main focus is on the molecular determinants of human phenotypes and their significance to chronic morbidity such as dementia, obesity, diabetes and heart disease later in life. His core interest is in Alzheimer’s disease, but he is also maintaining an active role in cardiometabolic and metabolomics research via international collaborations. He holds an EMBL Australia Group Leader position in the South Australian Health and Medical Research Institute (SAHMRI) in Adelaide, and he is affiliated with the Faculaty of Molecular and Biological Sciences at the University of Adelaide. The interest in systems genetics and epidemiology started early in A/Prof Mäkinen's career. In his doctoral thesis from Aalto University in Finland, he demonstrated the detrimental effects of the metabolic syndrome phenotype on the long-term adverse outcomes in type 1 diabetes. At the same time, he developed a method to statistically estimate the robustness of complex human phenotypes, helped develop a high-throughput NMR metabolomics platform, and applied both to a large nation-wide cohort of type 1 diabetes. The software is now available as the Numero R package. Before coming to Australia, A/Prof Mäkinen studied integrative genomics in Prof Xia Yang's group in University of California Los Angeles and published new insight into the causal genetic perturbations of gene regulatory networks that predispose to coronary artery disease. He also developed new methodology that was published recently as part of the Mergeomics web site and R package. In 2014, he was appointed to the prestigious EMBL Australia position at SAHMRI, where he is currently leading a cross-disciplinary research group that focuses on the translation of epidemiological results on dementia and other age-associated diseases into wet lab hypotheses and vice versa.

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Research Output 2005 2019

1 Citation (Scopus)

Numero: a statistical framework to define multivariable subgroups in complex population-based datasets

Gao, S., Mutter, S., Casey, A. & Makinen, V-P., 1 Jan 2019, In : International Journal of Epidemiology. 48, 2, p. 369-374 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes

Van Zuydam, N. R., Ahlqvist, E., Sandholm, N., Deshmukh, H., William Rayner, N., Abdalla, M., Ladenvall, C., Ziemek, D., Fauman, E., Robertson, N. R., McKeigue, P. M., Valo, E., Forsblom, C., Harjutsalo, V., Perna, A., Rurali, E., Loredana Marcovecchio, M., Igo, R. P., Salem, R. M., Perico, N. & 578 othersLajer, M., Käräjämäki, A., Imamura, M., Kubo, M., Takahashi, A., Sim, X., Liu, J., Van Dam, R. M., Jiang, G., Tam, C. H. T., Luk, A. O. Y., Lee, H. M., Lim, C. K. P., Szeto, C. C., So, W. Y., Chan, J. C. N., Ang, S. F., Dorajoo, R., Wang, L., Clara, T. S. H., McKnight, A. J., Duffy, S., Warren, Pezzolesi, M. G., Marre, M., Gyorgy, B., Hadjadj, S., Hiraki, L. T., Ahluwalia, T. S., Almgren, P., Schulz, C. A., Orho-Melander, M., Linneberg, A., Christensen, C., Witte, D. R., Grarup, N., Brandslund, I., Melander, O., Paterson, A. D., Tregouet, D., Maxwell, A. P., Lim, S. C., Ma, R. C. W., Shyong Tai, E., Maeda, S., Lyssenko, V., Tuomi, T., Krolewski, A. S., Rich, S. S., Hirschhorn, J. N., Florez, J. C., Dunger, D., Pedersen, O., Hansen, T., Rossing, P., Remuzzi, G., Brosnan, M. J., Palmer, C. N. A., Groop, P. H., Colhoun, H. M., Groop, L. C., McCarthy, M. I., Koivula, S., Uggeldahl, T., Forslund, T., Halonen, A., Koistinen, A., Koskiaho, P., Laukkanen, M., Saltevo, J., Tiihonen, M., Forsen, M., Granlund, H., Jonsson, A. C., Nyroos, B., Kinnunen, P., Orvola, A., Salonen, T., Vähänen, A., Paldanius, K. R., Riihelä, M., Ryysy, L., Laukkanen, K. H., Nyländen, P., Sademies, A., Anderson, S., Asplund, B., Byskata, U., Liedes, P., Kuusela, M., Virkkala, T., Nikkola, A., Ritola, E., Niska, T. M., Saarinen, H., Oukko-Ruponen, S. E., Virtanen, T., Lyytinen, V. A., Kari, P. H., Simonen, T., Kaprio, S. A., Kärkkäinen, J., Rantaeskola, B., Kääriäinen, T. P., Haaga, J., Pietiläinen, A. L., Klemetti, S., Nyandoto, T., Rontu, E., Satuli-Autere, S., Toivonen, K. R., Lansimaki, H. V., Ahonen, R., Ivaska-Suomela, M., Jauhiainen, A., Laine, M. M., Pellonpää, T., Puranen, R., Airas, M. A., Laakso, J., Rautavaara, K., Erola, R. M., Jatkola, E., Lönnblad, T. R., Malm, A., Mäkelä, J., Rautamo, E., Hentunen, P., Lagerstam, J., Feodoroff, M., Gordin, D., Heikkilä, O., Hietala, K., Fagerudd, J., Korolainen, M., Kyllönen, L., Kytö, J., Lindh, S., Pettersson-Fernholm, K., Rosengård-Bärlund, M., Sandelin, A., Thorn, L., Tuomikangas, J., Vesisenaho, T., Wadén, J., Sipilä, V., Kalliomäki, F. T., Koskelainen, J., Nikkanen, R., Savolainen, N., Sulonen, H., Valtonen, E., Norvio, L., Hämäläinen, A., Toivanen, E., Parta, J. A., Pirttiniemi, I., Aranko, S., Ervasti, S., Kauppinen-Mäkelin, R., Kuusisto, A., Leppälä, T., Nikkilä, K., Pekkonen, L., Jokelainen, K. S., Kananen, K., Karjalainen, M., Kemppainen, P., Mankinen, A. M., Reponen, A., Sankari, M., Suominen, P., Lappalainen, A., Liimatainen, M., Santaholma, J., Aimolahti, A., Huovinen, E., Ilkka, V., Lehtimäki, M., Pälikkö-Kontinen, E., Vanhanen, A., Koskinen, E., Siitonen, T., Huttunen, E., Ikäheimo, R., Karhapää, P., Kekäläinen, P., Laakso, M., Lakka, T., Lampainen, E., Moilanen, L., Tanskanen, S., Niskanen, L., Tuovinen, U., Vauhkonen, I., Voutilainen, E., Huang, Y., Lan, H. Y., Lok, S., Tomlinson, B., Tsui, S. K. W., Yu, W., Yip, K. Y. L., Chan, T. F., Fan, X., Tang, N., Tian, X., Chan, K. K. H., Xie, F., Ng, A. C. W., Cheung, G. P. Y., Yeung, M. W., Mai, S., Xie, F., Zhang, S., Yu, P., Weng, M., Savage, D. A., Walker, J., Thomas, S., Viberti, G. C., Boulton, A. J. M., Marshall, S., Demaine, A. G., Millward, B. A., Bain, S. C., Makinen, V-P., Ahola, A. J., Dahlström, E., Gordin, D., Heikkilä, O., Hietala, K., Kytö, J., Lehto, M., Lithovius, R., Panduru, N. M., Parkkonen, M., Rosengård-Bärlund, M., Saraheimo, M., Söderlund, J., Soro-Paavonen, A., Syreeni, A., Thorn, L. M., Tolonen, N., Wadén, J., McKay, G. J., Isakova, T., Guiducci, C., Taylor, A., Mirel, D. B., Williams, W. W., Brennan, E. P., Sadlier, D. M., Martin, F., Godson, C., Mayer, L., Gubitosi-Klug, R., Bourne, P., Schutta, M., Lackaye, M. E., Gregory, N. S., Kruger, D., Jones, J. K., Bhan, A., Golden, E., Aiello, L., Larkin, M., Nathan, D., Ziegler, G., Caulder, S., Pittman, C., Luttrell, L., Lopes-Virella, M., Johnson, M., Gunyou, K., Bergenstal, R., Vittetoe, B., Sivitz, W., Flaherty, N., Bantle, J., Hitt, S., Goldstein, D., Hainsworth, D., Cimino, L., Orchard, T., Wigley, C., Dagogo-Jack, S., Strowig, S., Raskin, P., Barnie, A., Zinman, B., Fahlstrom, R., Palmer, J., Harth, J., Driscoll, M., McDonald, C., Lipps Hagan, J., May, M., Levandoski, L., White, N., Gatcomb, P., Tamborlane, W., Adelman, D., Colson, S., Molitch, M., Lorenzi, G., Mudaliar, S., Johnsonbaugh, S., Miller, R., Canady, J., Schade, D., Bernal, M. L., Malone, J., Morrison, A., Martin, C., Herman, W., Pop-Busui, R., Cowie, C., Leschek, E., Cleary, P., Lachin, J., Zinman, B., Lorenzi, G., Braffett, B., Steffes, M., Arends, V., Blodi, B., Danis, R., Lawrence, D., Wabers, H., Soliman, E., Zhang, Z. M., Campbell, C., Hensley, S., Keasler, L., Mark, M., Albertini, M., Boustany, C., Ehlgen, A., Gerl, M., Huber, J., Schölch, C., Zimdahl-Gelling, H., Agardh, E., Ajanki, T., Al Maghrabi, N., Apelqvist, J., Bengtsson, E., Berglund, L., Björckbacka, H., Blom-Nilsson, U., Borell, M., Burström, A., Cilio, C., Cinthio, M., Dreja, K., Dunér, P., Engelbertsen, D., Fadista, J., Gomez, M., Goncalves, I., Hedblad, B., Hultgårdh, A., Johansson, M. E., Kennbäck, C., Kravic, J., Lernmark, A., Lindholm, E., Ling, C., Luthman, H., Neptin, M., Nilsson, J., Nilsson, P., Nilsson, T., Nordin, G., Ottoson-Laakso, E., Persson, A., Persson, M., Persson, M. A., Postma, J., Pranter, E., Rattik, S., Sterner, G., Tindberg, L., Wigren, M., Zetterqvist, A., Åkerlund, M., Ostling, G., Kanninen, T., Ahonen-Bishopp, A., Eliasson, A., Herrala, T., Tikka-Kleemola, P., Hamsten, A., Betsholtz, C., Björkholm, A., Foroogh, F., Genové, G., Gertow, K., Gigante, B., He, B., Leander, K., McLeod, O., Nastase-Mannila, M., Patrakka, J., Silveira, A., Strawbridge, R., Tryggvason, K., Vikström, M., Ohrvik, J., Österholm, A. M., Thorand, B., Gieger, C., Grallert, H., Ludwig, T., Nitz, B., Schneider, A., Wang-Sattler, R., Zierer, A., Benigni, A., Donadelli, R., Lesti, M. D., Noris, M., Piras, R., Ruggenenti, P., Chassin, L., Dalton, N., Deanfield, J., Horsford, J., Rice, C., Rudd, J., Walker, N., Whitehead, K., Wong, M., Adams, F., Akbar, T., Belch, J., Dove, F., Ellingford, A., Farran, B., Ferguson, M., Henderson, G., Houston, G., Khan, F., Leese, G., Livingstone, S., Looker, H., McCann, M., McGurnaghan, S., Morris, A., Newton, D., Pearson, E., Reekie, G., Smith, N., Shore, A., Aizawa, K., Ball, C., Bellenger, N., Casanova, F., Frayling, T., Gates, P., Gooding, K., Hattersley, A., Ling, R., Mawson, D., Shandas, R., Strain, D., Thorn, C., Smith, U., Hammarstedt, A., Häring, H., Sesti, G., Fagerholm, E., Parkkonen, M., Tolonen, N., Toppila, I., Salomaa, V., Havulinna, A., Kristiansson, K., Okamo, P., Peltola, T., Perola, M., Pietilä, A., Ripatti, S., Taimi, M., Ylä-Herttuala, S., Babu, M., Dijkstra, M., Gurzeler, E., Huusko, J., Kholová, I., Laakso, M., Merentie, M., Poikolainen, M., Groves, C., Juliusdottir, T., Karpe, F., Lagou, V., Morris, A., Cobelli, C., Di Camillo, B., Finotello, F., Sambo, F., Toffolo, G., Trifoglio, E., Bellazzi, R., Barbarini, N., Bucalo, M., Larizza, C., Magni, P., Malovini, A., Marini, S., Mulas, F., Quaglini, S., Sacchi, L., Vitali, F., Ferrannini, E., Boldrini, B., Kozakova, M., Mari, A., Morizzo, C., Mota, L., Natali, A., Palombo, C., Venturi, E., Walker, M., Patrono, C., Pagliaccia, F., Rocca, B., Nuutila, P., Haukkala, J., Knuuti, J., Roivainen, A., Saraste, A., McKeague, P., Colombo, M., Steckel-Hamann, B., Bokvist, K., Shankar, S., Thomas, M., Gan, L. M., Heinonen, S., Jönsson-Rylander, A. C., Momo, R., Schnecke, V., Unwin, R., Walentinsson, A., Whatling, C., Nogoceke, E., Pacheco, G. D., Formentini, I., Schindler, T., Tortoli, P., Bassi, L., Boni, E., Dallai, A., Guidi, F., Lenge, M., Matera, R., Ramalli, A., Ricci, S., Viti, J., Jablonka, B., Crowther, D., Gassenhuber, J., Hess, S., Hubschle, T., Juretschke, H. P., Rutten, H., Sadowski, T., Wohlfart, P., Clerin, V., Hyde, C., Malarstig, A., Pullen, N., Tilley, M., Tuthill, T. & Vangjeli, C., 1 Jul 2018, In : Diabetes. 67, 7, p. 1414-1427 14 p.

Research output: Contribution to journalArticle

Blood pressure response toRAAS inhibition predicts all-cause mortality for individuals with type 1 diabetes and albuminuria

Mutter, S., Lithovius, R., Makinen, V-P. & Groop, P-H., 2018.

Research output: Contribution to conferencePoster

File

Body Mass Index in Children Validated by Metabolic and Fat Mass Profiling

Makinen, V-P., 18 Dec 2018, In : Journal of the American College of Cardiology. 72, 24, p. 3155-3157 3 p.

Research output: Contribution to journalEditorial

Activities 2019 2019

  • 1 Participation in workshop, seminar, course
  • 1 Oral presentation

Pathway and network analysis in systems genetics

Ville-Petteri Makinen (Speaker)
27 Jun 2019

Activity: Talk or presentationOral presentation

EMBL Australia PhD Course

Ville-Petteri Makinen (Participant)
24 Jun 20195 Jul 2019

Activity: Participating in or organising an eventParticipation in workshop, seminar, course