• 126 Citations
  • 7 h-Index
20142020

Research output per year

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Personal profile

Public Profile

Dr Bill Panagopoulos is a NHMRC Early Career Fellow based at SAHMRI within the Myeloma Research Laboratory, University of Adelaide. After completing his Bachelor of Medical and Pharmaceutical Biotechnology at the University of South Australia in 2002, he spent almost 10 years in the private sector of clinical pathology, tissue growth and repair, and preclinical oncology for biotechnology and pharmaceutical industries. His industry experience provided the framework for his academic career and the completion of his PhD in November 2016 within the School of Medicine of The University of Adelaide. His PhD identified for the first time a causative role for inflammatory peroxidase enzymes in cancer development and metastasis. His findings were seminal in discovering a new role for peroxidase enzymes within the tumour, lung and bone microenvironments leading to new research projects. He has published 14 articles (3 first author, 1 senior author), is a co-inventor on 2 patents, and is currently a co-supervisor of 2 PhD students, and primary supervisor of 1 Honours student. His past supervision activities include 1 PhD and 2 Honours (first class) completions. Bill has also won numerous awards, including the 2017 Ross Wishart Memorial Award, a Dean’s Commendation for Doctoral Thesis Excellence, and a number of travel and professional development awards.

Research Interests

Dr Panagopoulos' research interests involve elucidating the role of the tumour microenvironment in promoting disease progression in cancer within bone, including multiple myeloma, and metastatic breast cancer. His primary focus is on translational research to identify novel therapeutic targets and molecular markers of disease risk to improve patient outcomes.

Dr Panagopoulos actively contributes to teaching for the Faculty of Health Sciences within The University of Adelaide, as an affiliate lecturer and tutor in Investigative Cell Biology (PATHOL3104). His contribution to the scientific community is further exemplified by his membership to international (IMF, MRS) and national (ASMR, OzMRS) societies and his role as convenor of the ASMR Scientific Meeting in 2018. Dr Panagopoulos is also actively involved in promoting support for medical research, providing numerous presentations to community events.

My primary research interest lies within the role of stromal cells within the tumour microenvironment on cancer growth and metastasis. This interest developed early on in my career but wasn't until my PhD (completed in 2016) where I became fascinated with targeting the stroma with novel therapeutic strategies to improve patient outcome.  

Current Projects:

-Determining the role of the aged bone microenvironment in the progression of multiple myeloma

-Investigating the role of inflammatory peroxidases driving multiple myeloma progression

-Characterising the therapeutic potential of targeting inflammatory peroxidases in pulmonary fibrosis

-Investigating the therapeutic potential for localised treatment of breast cancer with cytotoxic gamma delta T cells

 

Keywords

  • Multiple Myeloma
  • Tumour Microenvironment
  • Metastasis
  • targeted therapies
  • Breast Cancer

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Research Output

  • 126 Citations
  • 7 h-Index
  • 16 Article

Zoledronate Enhances the Cytotoxicity of Gamma Delta T Cell Immunotherapy in an Orthotopic Mouse Model of Osteolytic Osteosarcoma

Zysk, A., Denichilo, M., Zinonos, I., Hay, S., Liapis, V., Ponomarev, V., Zannettino, A., Evdokiou, A. & Panagopoulos, V., 12 Sep 2018, In : Journal of Cancer Science & Therapy.

Research output: Contribution to journalArticle

Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer

Zysk, A., DeNichilo, M. O., Panagopoulos, V., Zinonos, I., Liapis, V., Hay, S., Ingman, W., Ponomarev, V., Atkins, G., Findlay, D., Zannettino, A. & Evdokiou, A., 1 Feb 2017, In : Cancer Letters. 386, p. 141-150 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma

Liapis, V., Zysk, A., DeNichilo, M., Zinonos, I., Hay, S., Panagopoulos, V., Shoubridge, A., Difelice, C., Ponomarev, V., Ingman, W., Atkins, G. J., Findlay, D. M., Zannettino, A. C. W. & Evdokiou, A., 1 Sep 2017, In : Cancer Medicine. 6, 9, p. 2164-2176 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)