• 381 Citations
  • 11 h-Index
20072019

Research output per year

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Personal profile

Public Profile

Dr Tim Sargeant started his career in neuroscience with a PhD at Victoria University of Wellington, New Zealand. Tim went on to two postdoctoral positions at the Department of Medicine and the Department of Pathology at the University of Cambridge (UK) where he researched the cell’s recycling machinery (called the lysosomal system) and obtained training in molecular and cell biology. Tim was appointed to head of Lysosomal Health in Ageing in the Hopwood Centre for Neurobiology (formally the Lysosomal Diseases Research Unit) at SAHMRI in 2015. His current research focuses on the role of lysosomal recycling in common neurodegenerative disease such as Alzheimer’s disease.

The lysosomal system is important for slowing cell ageing, as it removes damaged and unwanted material from the cell. This process is critically important for healthy brain function. Work from Lysosomal Health in Ageing has shown that this system is damaged in Alzheimer’s disease, and that changes in genes that are involved in the lysosomal system are associated with Alzheimer’s disease. Our current research focuses on development of methods for measurement of lysosomal system activity (through a process called autophagy) in humans. We are also developing interventions that improve the lysosomal system with the goal of delaying Alzheimer’s disease.

Keywords

  • Autophagy
  • Alzheimer's disease
  • Lysosomes
  • Neuroscience
  • Cell Biology
  • Molecular Genetics
  • Dementia
  • Biochemistry

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Research Output

  • 381 Citations
  • 11 h-Index
  • 15 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter

Autophagy modulation as a treatment of amyloid diseases

Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R. & Bharadwaj, P., 16 Sep 2019, In : Molecules. 24, 18, 3372.

Research output: Contribution to journalReview article

10 Citations (Scopus)

Rapamycin and Alzheimer disease: a double-edged sword?

Carosi, J. M. & Sargeant, T., 22 May 2019, In : Autophagy. 15, 8, p. 1460-1462 3 p.

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

Retromer has a selective function in cargo sorting via endosome transport carriers

Cui, Y., Carosi, J. M., Yang, Z., Ariotti, N., Kerr, M. C., Parton, R. G., Sargeant, T. J. & Teasdale, R. D., 1 Feb 2019, In : Journal of Cell Biology. 218, 2, p. 615-631 17 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease

Gao, S., Casey, A., Sargeant, T. & Makinen, V-P., 1 Sep 2018, In : Brain. 141, 9, p. 2711-2720 10 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

Hassiotis, S., Manavis, J., Blumbergs, P. C., Hattersley, K., Carosi, J. M., Kamei, M. & Sargeant, T., 1 May 2018, In : European Journal of Neuroscience. 47, 9, p. 1043-1053 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)