Timothy Sargeant

PhD

  • 289 Citations
  • 10 h-Index
20072019
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Having completed a PhD at Victoria University of Wellington, New Zealand, Tim went on to two postdoctoral positions at the Department of Medicine and the Department of Pathology at the University of Cambridge. During his first postdoctoral position, under Prof TM Cox and Dr MB Cachón-González, Tim developed an understanding of lysosomal biology while working on rare neurological diseases. It was during this time that he also gained rigorous training in molecular techniques.

During his second postdoctoral position, under the guidance of Prof CJ Watson, Tim researched extreme examples of lysosomal physiology in the involuting mammary gland. This work provided Tim with further valuable experience in cell biology and advanced molecular techniques, such as CRISPR/Cas9 genome editing and use of lentivirus.

Tim was appointed to head the Neurobiology Section in the Hopwood Centre for Neurobiology (formally the Lysosomal Diseases Research Unit) at SAHMRI in 2015. His current research focuses on the role of the lysosomal network in common neurodegenerative disease such as Alzheimer’s disease. 

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Research Output 2007 2019

  • 289 Citations
  • 10 h-Index
  • 15 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter

Autophagy modulation as a treatment of amyloid diseases

Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R. & Bharadwaj, P., 16 Sep 2019, In : Molecules. 24, 18, 3372.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Rapamycin and Alzheimer disease: a double-edged sword?

Carosi, J. M. & Sargeant, T., 22 May 2019, In : Autophagy. 15, 8, p. 1460-1462 3 p.

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

Retromer has a selective function in cargo sorting via endosome transport carriers

Cui, Y., Carosi, J. M., Yang, Z., Ariotti, N., Kerr, M. C., Parton, R. G., Sargeant, T. J. & Teasdale, R. D., 1 Feb 2019, In : Journal of Cell Biology. 218, 2, p. 615-631 17 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Genetic variation within endolysosomal system is associated with late-onset Alzheimer's disease

Gao, S., Casey, A., Sargeant, T. & Makinen, V-P., 1 Sep 2018, In : Brain. 141, 9, p. 2711-2720 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Lysosomal LAMP1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

Hassiotis, S., Manavis, J., Blumbergs, P. C., Hattersley, K., Carosi, J. M., Kamei, M. & Sargeant, T., 1 May 2018, In : European Journal of Neuroscience. 47, 9, p. 1043-1053 11 p.

Research output: Contribution to journalArticle