Timothy Hughes

Professor

  • 30979 Citations
  • 74 h-Index
1989 …2019
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Personal profile

Public Profile

Professor Timothy Hughes is the Cancer Theme Leader at SAHMRI and Consultant Haematologist in the Division of Haematology at SA Pathology. He is also the Cancer Council Beat Cancer Professor, University of Adelaide, Chair of the International Chronic Myeloid Leukemia Foundation (iCMLf) and Fellow of the Australian Academy of Health and Medical Sciences (AAHMS).

Professor Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays and molecular targets that influence the way CML patients are managed world-wide. He has published over 250 papers that have been cited over 40,000 times. 

In October 2017 Professor Hughes was awarded the GSK Award for Research Excellence 2017 for pioneering the use of tyrosine kinase inhibitors (TKIs).

Education/Academic qualification

PhD, Doctor of Medicine , University of New South Wales

… → 1993

Fellowship of the Royal Australasian College of Physicians

… → 1988

Fellowship of the Royal College of Pathologists of Australia

… → 1988

MB BS (Honours), University of New South Wales

… → 1981

External positions

Consultant Haematologist , SA Pathology

Beat Cancer Professor, University of Adelaide

Chair, International CML Foundation

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Research Output 1989 2019

Bone marrow fibrosis associated with long-term imatinib therapy: resolution after switching to a second-generation TKI

Shanmuganathan, N., Branford, S., Hughes, T. & Hiwase, D., 12 Feb 2019, In : Blood advances. 3, 3, p. 370-374 5 p.

Research output: Contribution to journalArticle

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for philadelphia chromosome-positive leukemia

Hughes, T. P., Laneuville, P., Rousselot, P., Snyder, D. S., Rea, D., Shah, N. P., Paar, D., Abruzzese, E., Hochhaus, A., Lipton, J. H. & Cortes, J. E., 2019, In : Haematologica. 104, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis

Tvorogov, D., Thomas, D., Liau, N. P. D., Dottore, M., Barry, E. F., Lathi, M., Kan, W. L., Hercus, T. R., Stomski, F., Hughes, T., Tergaonkar, V., Parker, M. W., Ross, D. M., Majeti, R., Babon, J. J. & Lopez, A. F., 28 Nov 2018, In : Science Advances. 4, 11, eaat3834.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Broughton, S. E., Hercus, T. R., Nero, T. L., Kan, W. L., Barry, E. F., Dottore, M., Cheung Tung Shing, K. S., Morton, C. J., Dhagat, U., Hardy, M. P., Wilson, N. J., Downton, M. T., Schieber, C., Hughes, T., Lopez, A. F. & Parker, M. W., 1 Jan 2018, In : Nature Communications. 9, 1, 386.

Research output: Contribution to journalArticle