Tim Kuchel

Dr

  • 1385 Citations
  • 21 h-Index
1980 …2018
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Personal profile

Public Profile

Dr Tim Kuchel, is the director of the Preclinical, Imaging and Research Laboratories (PIRL) of the South Australian Health and Medical Research Institute (SAHMRI). It is PIRL which hosts the NIF - funded Large Animal Research and Imaging Facility (LARIF). Dr. Kuchel has more than 30 years’ experience with a special interest in imaging modalities, experimental surgery and comparative anaesthesia. The capacity to provide or help develop Large Animal Models of human disease is the core business of LARIF and PIRL, and interactions with industry to add to existing translational medicine capacity are being actively pursued by Dr. Kuchel and his team.

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Research Output 1980 2018

  • 1385 Citations
  • 21 h-Index
  • 59 Article
  • 2 Letter
  • 1 Comment/debate

Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Wang, D., Zhong, L., Li, M., Li, J., Tran, K., Ren, L., He, R., Xie, J., Moser, R. P., Fraser, C., Kuchel, T., Sena-Esteves, M., Flotte, T. R., Aronin, N. & Gao, G. 14 Dec 2018 In : Molecular Therapy - Methods and Clinical Development. 11, p. 65-72 8 p.

Research output: Research - peer-reviewArticle

7 Citations

Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease

Pfister, E. L. , Dinardo, N. , Mondo, E. , Borel, F. , Conroy, F. , Fraser, C. , Gernoux, G. , Han, X. , Hu, D. , Johnson, E. , Kennington, L. , Liu, P. , Reid, S. J. , Sapp, E. , Vodicka, P. , Kuchel, T. , Morton, A. J. , Howland, D. , Moser, R. , Sena-Esteves, M. & 4 others Gao, G., Mueller, C., Difiglia, M. & Aronin, N. 1 Jun 2018 In : Human Gene Therapy. 29, 6, p. 663-673 11 p.

Research output: Research - peer-reviewArticle

Correction: Gestational dietary protein is associated with sex specific decrease in blood flow, fetal heart growth and postnatal blood pressure of progeny (PLoS ONE (2015) 10:4 (e0125694) DOI: 10.1371/journal.pone.0125694)

Hernandez-Medrano, J. H., Copping, K. J., Hoare, A., Wapanaar, W., Grivell, R., Kuchel, T., Miguel-Pacheco, G., Caroline McMillen, I., Rodgers, R. J. & Perry, V. E. A. 1 May 2018 In : PLoS ONE. 13, 5, e0197942

Research output: Research - peer-reviewComment/debate

1 Citations

Delivery of siRNA in vitro and in vivo using PEI-capped porous silicon nanoparticles to silence MRP1 and inhibit proliferation in glioblastoma

Tong, W. Y., Alnakhli, M., Bhardwaj, R., Apostolou, S., Sinha, S., Fraser, C., Kuchel, T., Kuss, B. & Voelcker, N. H. 13 Apr 2018 In : Journal of Nanobiotechnology. 16, 1, 38

Research output: Research - peer-reviewArticle

Evaluation of relative bioaccessibility leaching procedure for an assessment of lead bioavailability in mixed metal contaminated soils

Wijayawardena, M. A. A., Naidu, R., Megharaj, M., Lamb, D., Thavamani, P. & Kuchel, T. 1 Apr 2017 In : Environmental Technology and Innovation. 7, p. 229-238 10 p.

Research output: Research - peer-reviewArticle

Activities 2018 2018

  • 1 Oral presentation

Diffusion Tensor Imaging of Huntington’s Disease in Sheep at 3T MRI

Erin Batcho (Speaker), Perumal, R. (Speaker), Keller, M. (Speaker), Kuchel, T. (Speaker), Sundeep Chandra (Speaker), Tom Denney (Speaker), Heather Gray-Edwards (Speaker)
17 Nov 2018

Activity: Oral presentation