My PhD research centred on the mechanisms underlying bone marrow angiogenesis and osteolytic bone disease in the haematological malignancy, multiple myeloma. Since completing my PhD in 2009, my research has focussed on examining the role of the PI3K and mTOR signalling pathways in bone development, looking at ways to exploit these pathways to stimulate bone formation in disease settings such as osteoporosis and tumour-associated bone loss.

My current projects include:

(1) Examining the role of the mTOR signalling pathways in directing mesenchymal stem cell differentiation

(2) Examining the consequences of conditional bone-specific mTORC1 deletion on skeletal development and bone remodelling

(3) Examining the role of skeletal mTORC1 in regulating whole body glucose homeostasis

(4) Examining the role of skeletal mTORC1 in regulating bone marrow adipose expansion