Research output per year
Research output per year
Personal profile
Public Profile
My PhD research centred on the mechanisms underlying bone marrow angiogenesis and osteolytic bone disease in the haematological malignancy, multiple myeloma. Since completing my PhD in 2009, my research has focussed on examining the role of the PI3K and mTOR signalling pathways in bone development, looking at ways to exploit these pathways to stimulate bone formation in disease settings such as osteoporosis and tumour-associated bone loss.
My current projects include:
(1) Examining the role of the mTOR signalling pathways in directing mesenchymal stem cell differentiation
(2) Examining the consequences of conditional bone-specific mTORC1 deletion on skeletal development and bone remodelling
(3) Examining the role of skeletal mTORC1 in regulating whole body glucose homeostasis
(4) Examining the role of skeletal mTORC1 in regulating bone marrow adipose expansion
Education/Academic qualification
PhD, University of Adelaide
6 Mar 2005 → 18 Dec 2008
Award Date: 3 Aug 2009
External positions
Course coordinator, Human Anatomy and Physiology, University of Adelaide
1 Jul 2019 → …Affiliate lecturer, School of Medicine, University of Adelaide
2012 → …Keywords
- mTOR
- bone biology
- glucose metabolism
- Multiple myeloma
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Deletion of Rptor in Preosteoblasts Reveals a Role for the Mammalian Target of Rapamycin Complex 1 (mTORC1) Complex in Dietary-Induced Changes to Bone Mass and Glucose Homeostasis in Female Mice
Tangseefa, P., Martin, S. K., Arthur, A., Panagopoulos, V., Page, A. J., Wittert, G. A., Proud, C. G., Fitter, S. & Zannettino, A. C. W., May 2021, In: JBMR Plus. 5, 5, e10486.Research output: Contribution to journal › Article › peer-review
Open Access -
The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin
Tangseefa, P., Martin, S. K., Chin, P. Y., Breen, J., Mah, C. Y., Baldock, P. A., Wittert, G. A., Page, A. J., Proud, C. G., Fitter, S. & Zannettino, A. C. W., 8 Feb 2021, In: Bone Research. 9, 1, p. 10Research output: Contribution to journal › Article › peer-review
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The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin
Tangseefa, P., Martin, S. K., Chin, P. Y., Breen, J., Mah, C. Y., Baldock, P. A., Wittert, G. A., Page, A. J., Proud, C. G., Fitter, S. & Zannettino, A. C. W., Dec 2021, In: Bone Research. 9, 1, 10.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis
Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K. B., Trim, P. J., Snel, M. F., Kamei, M., Martin, S. K., Fitter, S., Tian, S., Wang, X. & 3 others, , 13 Mar 2020, In: Cellular and Molecular Life Sciences. 78, 1, p. 249-270 22 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Martin, S. K., Fitter, S., El Khawanky, N., Grose, R., Walkley, C. R., Purton, L. E., Ruegg, M. A., Hall, M. N., Gronthos, S. & Zannettino, A., 1 Dec 2018, In: Scientific reports. 8, 1, 14501.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)