If you made any changes in Pure these will be visible here soon.

Personal profile

Public Profile

My PhD research centred on the mechanisms underlying bone marrow angiogenesis and osteolytic bone disease in the haematological malignancy, multiple myeloma. Since completing my PhD in 2009, my research has focussed on examining the role of the PI3K and mTOR signalling pathways in bone development, looking at ways to exploit these pathways to stimulate bone formation in disease settings such as osteoporosis and tumour-associated bone loss.

My current projects include:

(1) Examining the role of the mTOR signalling pathways in directing mesenchymal stem cell differentiation

(2) Examining the consequences of conditional bone-specific mTORC1 deletion on skeletal development and bone remodelling

(3) Examining the role of skeletal mTORC1 in regulating whole body glucose homeostasis

(4) Examining the role of skeletal mTORC1 in regulating bone marrow adipose expansion

 

 

Education/Academic qualification

PhD, University of Adelaide

6 Mar 200518 Dec 2008

External positions

Course coordinator, Human Anatomy and Physiology, University of Adelaide

1 Jul 2019 → …

Affiliate lecturer, School of Medicine, University of Adelaide

2012 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2005 2018

  • 688 Citations
  • 13 h-Index
  • 15 Article
  • 2 Review article
  • 1 Letter
1 Citation (Scopus)

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis

Martin, S. K., Fitter, S., El Khawanky, N., Grose, R., Walkley, C. R., Purton, L. E., Ruegg, M. A., Hall, M. N., Gronthos, S. & Zannettino, A., 1 Dec 2018, In : Scientific Reports. 8, 1, 14501.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance

Tangseefa, P., Martin, S. K., Fitter, S., Baldock, P. A., Proud, C. G. & Zannettino, A. C. W., 1 May 2018, In : Journal of Cellular Physiology. 233, 5, p. 3769-3783 15 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

HIF-2α promotes dissemination of plasma cells in multiple myeloma by regulating CXCL12/CXCR4 and CCR1

Vandyke, K., Zeissig, M. N., Hewett, D. R., Martin, S. K., Mrozik, K. M., Cheong, C. M., Diamond, P., To, L. B., Gronthos, S., Peet, D. J., Croucher, P. I. & Zannettino, A. C. W., 15 Oct 2017, In : Cancer Research. 77, 20, p. 5452-5463 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation

Fitter, S., Matthews, M. P., Martin, S. K., Xie, J., Ooi, S. S., Walkley, C. R., Codrington, J. D., Ruegg, M. A., Hall, M. N., Proud, C. G., Gronthos, S. & Zannettino, A. C. W., 1 Jan 2017, In : Molecular and Cellular Biology. 37, 7, e00668-16.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Brief report: The differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation

Martin, S. K., Fitter, S., Dutta, A. K., Matthews, M. P., Walkley, C. R., Hall, M. N., Ruegg, M. A., Gronthos, S. & Zannettino, A. C. W., 1 Apr 2015, In : Stem Cells. 33, 4, p. 1359-1365 7 p.

Research output: Contribution to journalArticle