Research Output per year
Personal profile
Public Profile
My PhD research centred on the mechanisms underlying bone marrow angiogenesis and osteolytic bone disease in the haematological malignancy, multiple myeloma. Since completing my PhD in 2009, my research has focussed on examining the role of the PI3K and mTOR signalling pathways in bone development, looking at ways to exploit these pathways to stimulate bone formation in disease settings such as osteoporosis and tumour-associated bone loss.
My current projects include:
(1) Examining the role of the mTOR signalling pathways in directing mesenchymal stem cell differentiation
(2) Examining the consequences of conditional bone-specific mTORC1 deletion on skeletal development and bone remodelling
(3) Examining the role of skeletal mTORC1 in regulating whole body glucose homeostasis
(4) Examining the role of skeletal mTORC1 in regulating bone marrow adipose expansion
Education/Academic qualification
PhD, University of Adelaide
6 Mar 2005 → 18 Dec 2008
External positions
Course coordinator, Human Anatomy and Physiology, University of Adelaide
1 Jul 2019 → …Affiliate lecturer, School of Medicine, University of Adelaide
2012 → …Keywords
- mTOR
- bone biology
- glucose metabolism
- Multiple myeloma
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output
Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis
Xie, J., Shen, K., Jones, A. T., Yang, J., Tee, A. R., Shen, M. H., Yu, M., Irani, S., Wong, D., Merrett, J. E., Lenchine, R. V., De Poi, S., Jensen, K., Trim, P., Snel, M., Kamei, M., Martin, S., Fitter, S., Tian, S., Wang, X. & 3 others, , 1 Jan 2020, In : Cellular and Molecular Life Sciences.Research output: Contribution to journal › Article
1
Citation
(Scopus)
mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Martin, S. K., Fitter, S., El Khawanky, N., Grose, R., Walkley, C. R., Purton, L. E., Ruegg, M. A., Hall, M. N., Gronthos, S. & Zannettino, A., 1 Dec 2018, In : Scientific reports. 8, 1, 14501.Research output: Contribution to journal › Article
1
Citation
(Scopus)
Osteocalcin-dependent regulation of glucose metabolism and fertility: Skeletal implications for the development of insulin resistance
Tangseefa, P., Martin, S. K., Fitter, S., Baldock, P. A., Proud, C. G. & Zannettino, A. C. W., 1 May 2018, In : Journal of Cellular Physiology. 233, 5, p. 3769-3783 15 p.Research output: Contribution to journal › Review article
8
Citations
(Scopus)
HIF-2α promotes dissemination of plasma cells in multiple myeloma by regulating CXCL12/CXCR4 and CCR1
Vandyke, K., Zeissig, M. N., Hewett, D. R., Martin, S. K., Mrozik, K. M., Cheong, C. M., Diamond, P., To, L. B., Gronthos, S., Peet, D. J., Croucher, P. I. & Zannettino, A. C. W., 15 Oct 2017, In : Cancer Research. 77, 20, p. 5452-5463 12 p.Research output: Contribution to journal › Article
15
Citations
(Scopus)
mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation
Fitter, S., Matthews, M. P., Martin, S. K., Xie, J., Ooi, S. S., Walkley, C. R., Codrington, J. D., Ruegg, M. A., Hall, M. N., Proud, C. G., Gronthos, S. & Zannettino, A. C. W., 1 Jan 2017, In : Molecular and Cellular Biology. 37, 7, e00668-16.Research output: Contribution to journal › Article
24
Citations
(Scopus)