Research Output per year
Personal profile
Research Interests
- Neurotrauma
- Neuropharmacology
- Molecular Biology
- Glia
- Oxidative stress
- Calcium dynamics
- Nuclear Imaging
- MRI
Public Profile
Ryan’s early research career has focused on understanding the pathophysiology of secondary degeneration following neurotrauma to the central nervous system (CNS). He uses innovative analytical techniques to demonstrate biochemical, molecular and gross anatomical changes that occur following CNS injury. Ryan has developed and optimised a combinatorial treatment strategy incorporating pharmacotherapeutics for the treatment of CNS injury. Ryan’s combinatorial strategy has been assessed in a clinically relevant model of spinal cord injury (SCI), demonstrating significant functional recovery and tissue sparing, crucial for the translation of his research into clinical trials.
In 2017, Ryan joined the SAHMRI Mind & Brain team in collaboration with Project Discovery and the Neil Sachse Centre for Spinal Cord Research, to provide his expertise in SCI and other neurotrauma models. Ryan looks to help develop new techniques to provide a more accurate diagnosis and prognosis of SCI, to identify potential treatment strategies in a clinical setting.
Education/Academic qualification
Bachelor's Degree, University of Western Australia
Bachelor's Degree (Honours), University of Western Australia
PhD, University of Western Australia
External positions
Project Manager, Project Discovery
9 Jan 2017 → 29 May 2020Adjunct Lecturer, School of Medicine, The University of Adelaide, Adelaide, Australia.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2013 2018
18-kDa translocator protein radioligand [18F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury
O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C., 2018.Research output: Contribution to conference › Poster
1
Citation
(Scopus)
Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors
Yates, N. J., Giacci, M. K., O'Hare Doig, R., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. A. & Fitzgerald, M., 1 Feb 2017, In : Neural Regeneration Research. 12, 2, p. 307-316 10 p.Research output: Contribution to journal › Article
6
Citations
(Scopus)
Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma
O'Hare Doig, R., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In : BMC Neuroscience. 18, 1, 62.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro
O'Hare Doig, R., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M., 17 Dec 2016, In : Neuroscience. 339, p. 450-462 13 p.Research output: Contribution to journal › Article
27
Citations
(Scopus)
Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties
Meloni, B. P., Milani, D., Edwards, A. B., Anderton, R. S., O'Hare Doig, R. L., Fitzgerald, M., Palmer, T. N. & Knuckey, N. W., 4 Aug 2015, In : Pharmacology and Therapeutics. 153, p. 36-54 19 p., 6788.Research output: Contribution to journal › Review article
Prizes
Australian Postgraduate Award (Scholarship)
Ryan O'Hare Doig (Recipient), 2013
Prize: Other distinction
Activities 2013 2018
South Australian Health & Medical Research Institute Animal Ethics Committee (External organisation)
Ryan O'Hare Doig (Chair)2018 → …
Activity: Membership › Membership of committee
National Neurotrauma Society (External organisation)
Ryan O'Hare Doig (Chair)2018 → …
Activity: Membership › Membership of committee
Spinal Cord Series and Cases (Journal)
Ryan O'Hare Doig (Reviewer)2017 → 2018
Activity: Publication peer-review and editorial work › Editorial activity
Toxicon (Journal)
Ryan O'Hare Doig (Reviewer)2017 → 2018
Activity: Publication peer-review and editorial work › Editorial activity
Spinal Cord (Journal)
Ryan O'Hare Doig (Reviewer)2017 → 2018
Activity: Publication peer-review and editorial work › Editorial activity