Ryan O'Hare Doig

Dr

  • 105 Citations
  • 5 h-Index
20132018
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Personal profile

Research Interests

  • Neurotrauma
  • Neuropharmacology
  • Molecular Biology
  • Glia
  • Oxidative stress
  • Calcium dynamics
  • Nuclear Imaging
  • MRI

Public Profile

Ryan’s early research career has focused on understanding the pathophysiology of secondary degeneration following neurotrauma to the central nervous system (CNS). He uses innovative analytical techniques to demonstrate biochemical, molecular and gross anatomical changes that occur following CNS injury. Ryan has developed and optimised a combinatorial treatment strategy incorporating pharmacotherapeutics for the treatment of CNS injury. Ryan’s combinatorial strategy has been assessed in a clinically relevant model of spinal cord injury (SCI), demonstrating significant functional recovery and tissue sparing, crucial for the translation of his research into clinical trials.

In 2017, Ryan joined the SAHMRI Mind & Brain team in collaboration with Project Discovery and the Neil Sachse Centre for Spinal Cord Research, to provide his expertise in SCI and other neurotrauma models. Ryan looks to help develop new techniques to provide a more accurate diagnosis and prognosis of SCI, to identify potential treatment strategies in a clinical setting.

Education / Academic qualification

Bachelor's Degree, University of Western Australia

Bachelor's Degree (Honours), University of Western Australia

PhD, University of Western Australia

External positions

Project Manager, Project Discovery

9 Jan 201729 May 2020

Adjunct Lecturer, School of Medicine, The University of Adelaide, Adelaide, Australia.

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Research Output 2013 2018

  • 105 Citations
  • 5 h-Index
  • 9 Article
  • 1 Poster
1 Citations

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

Yates, N. J., Giacci, M. K., O’Hare Doig, R. L., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. A. & Fitzgerald, M. 1 Feb 2017 In : Neural Regeneration Research. 12, 2, p. 307-316 10 p.

Research output: Research - peer-reviewArticle

2 Citations

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

O'Hare Doig, R. L., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M. 14 Aug 2017 In : BMC Neuroscience. 18, 1, 62

Research output: Research - peer-reviewArticle

4 Citations

Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro

O'Hare Doig, R. L., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M. 17 Dec 2016 In : Neuroscience. 339, p. 450-462 13 p.

Research output: Research - peer-reviewArticle

25 Citations

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

Meloni, B. P., Milani, D., Edwards, A. B., Anderton, R. S., O'Hare Doig, R. L., Fitzgerald, M., Palmer, T. N. & Knuckey, N. W. 4 Aug 2015 In : Pharmacology and Therapeutics. 153, p. 36-54 19 p., 6788

Research output: Research - peer-reviewArticle

Activities 2013 2018

  • 7 Editorial activity
  • 4 Membership of committee
  • 1 Membership of board

National Neurotrauma Society (External organisation)

O'Hare Doig, R. (Chair)
2018 → …

Activity: Membership of committee

European Spine Journal (Journal)

O'Hare Doig, R. (Reviewer)
20172018

Activity: Editorial activity

Toxicon (Journal)

O'Hare Doig, R. (Reviewer)
20172018

Activity: Editorial activity

Journal of Neurochemistry (Journal)

O'Hare Doig, R. (Reviewer)
20172018

Activity: Editorial activity