Ryan O'Hare Doig

Dr

  • 117 Citations
  • 6 h-Index
20132018
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Personal profile

Research Interests

  • Neurotrauma
  • Neuropharmacology
  • Molecular Biology
  • Glia
  • Oxidative stress
  • Calcium dynamics
  • Nuclear Imaging
  • MRI

Public Profile

Ryan’s early research career has focused on understanding the pathophysiology of secondary degeneration following neurotrauma to the central nervous system (CNS). He uses innovative analytical techniques to demonstrate biochemical, molecular and gross anatomical changes that occur following CNS injury. Ryan has developed and optimised a combinatorial treatment strategy incorporating pharmacotherapeutics for the treatment of CNS injury. Ryan’s combinatorial strategy has been assessed in a clinically relevant model of spinal cord injury (SCI), demonstrating significant functional recovery and tissue sparing, crucial for the translation of his research into clinical trials.

In 2017, Ryan joined the SAHMRI Mind & Brain team in collaboration with Project Discovery and the Neil Sachse Centre for Spinal Cord Research, to provide his expertise in SCI and other neurotrauma models. Ryan looks to help develop new techniques to provide a more accurate diagnosis and prognosis of SCI, to identify potential treatment strategies in a clinical setting.

Education/Academic qualification

Bachelor's Degree, University of Western Australia

Bachelor's Degree (Honours), University of Western Australia

PhD, University of Western Australia

External positions

Project Manager, Project Discovery

9 Jan 201729 May 2020

Adjunct Lecturer, School of Medicine, The University of Adelaide, Adelaide, Australia.

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Research Output 2013 2018

  • 117 Citations
  • 6 h-Index
  • 8 Article
  • 1 Poster
  • 1 Review article

18-kDa translocator protein radioligand [18F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury

O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C., 2018.

Research output: Contribution to conferencePoster

1 Citation (Scopus)

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

Yates, N. J., Giacci, M. K., O'Hare Doig, R., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. A. & Fitzgerald, M., 1 Feb 2017, In : Neural Regeneration Research. 12, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

O'Hare Doig, R., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In : BMC Neuroscience. 18, 1, 62.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro

O'Hare Doig, R., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M., 17 Dec 2016, In : Neuroscience. 339, p. 450-462 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

Meloni, B. P., Milani, D., Edwards, A. B., Anderton, R. S., O'Hare Doig, R. L., Fitzgerald, M., Palmer, T. N. & Knuckey, N. W., 4 Aug 2015, In : Pharmacology and Therapeutics. 153, p. 36-54 19 p., 6788.

Research output: Contribution to journalReview article

Activities 2013 2018

  • 7 Editorial activity
  • 4 Membership of committee
  • 1 Membership of board

South Australian Health & Medical Research Institute Animal Ethics Committee (External organisation)

Ryan O'Hare Doig (Chair)
2018 → …

Activity: MembershipMembership of committee

National Neurotrauma Society (External organisation)

Ryan O'Hare Doig (Chair)
2018 → …

Activity: MembershipMembership of committee

Spinal Cord Series and Cases (Journal)

Ryan O'Hare Doig (Reviewer)
20172018

Activity: Publication peer-review and editorial workEditorial activity

European Spine Journal (Journal)

Ryan O'Hare Doig (Reviewer)
20172018

Activity: Publication peer-review and editorial workEditorial activity

Neil Sachse Centre for Spinal Cord Research (External organisation)

Ryan O'Hare Doig (Chair)
20172020

Activity: MembershipMembership of board