Ryan O'Hare Doig

Personal profile

Research Interests

Neurotrauma
Neuropharmacology
Molecular Biology
Glia
Oxidative stress
Calcium dynamics
Nuclear Imaging
MRI

Public Profile

Ryan’s early research career has focused on understanding the pathophysiology of secondary degeneration following neurotrauma to the central nervous system (CNS). He uses innovative analytical techniques to demonstrate biochemical, molecular and gross anatomical changes that occur following CNS injury. Ryan has developed and optimised a combinatorial treatment strategy incorporating pharmacotherapeutics for the treatment of CNS injury. Ryan’s combinatorial strategy has been assessed in a clinically relevant model of spinal cord injury (SCI), demonstrating significant functional recovery and tissue sparing, crucial for the translation of his research into clinical trials.

In 2017, Ryan joined the SAHMRI Mind & Brain team in collaboration with Project Discovery and the Neil Sachse Centre for Spinal Cord Research, to provide his expertise in SCI and other neurotrauma models. Ryan looks to help develop new techniques to provide a more accurate diagnosis and prognosis of SCI, to identify potential treatment strategies in a clinical setting.

Education / Academic qualification

Bachelor's Degree, University of Western Australia

Bachelor's Degree (Honours), University of Western Australia

PhD, University of Western Australia

External positions

Project Manager, Project Discovery

9 Jan 2017 → 29 May 2020

Adjunct Lecturer, School of Medicine, The University of Adelaide, Adelaide, Australia.

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Research Output 2013 2018

105 Citations
5 h-Index
9 Article
1 Poster

18-kDa translocator protein radioligand [¹⁸F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury

O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C. 2018

Research output: Research - peer-review › Poster

1 Citations

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

Yates, N. J., Giacci, M. K., O’Hare Doig, R. L., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. A. & Fitzgerald, M. 1 Feb 2017 In : Neural Regeneration Research. 12, 2, p. 307-316 10 p.

Research output: Research - peer-review › Article

2 Citations

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

O'Hare Doig, R. L., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M. 14 Aug 2017 In : BMC Neuroscience. 18, 1, 62

Research output: Research - peer-review › Article

4 Citations

Specific combinations of ion channel inhibitors reduce excessive Ca²⁺ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro

O'Hare Doig, R. L., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M. 17 Dec 2016 In : Neuroscience. 339, p. 450-462 13 p.

Research output: Research - peer-review › Article

25 Citations

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

Meloni, B. P., Milani, D., Edwards, A. B., Anderton, R. S., O'Hare Doig, R. L., Fitzgerald, M., Palmer, T. N. & Knuckey, N. W. 4 Aug 2015 In : Pharmacology and Therapeutics. 153, p. 36-54 19 p., 6788

Research output: Research - peer-review › Article