Ryan O'Hare Doig

Dr

  • 165 Citations
  • 7 h-Index
20132020

Research output per year

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Personal profile

Research Interests

  • Neurotrauma
  • Neuropharmacology
  • Molecular Biology
  • Glia
  • Oxidative stress
  • Calcium dynamics
  • Nuclear Imaging
  • MRI

Public Profile

Ryan’s early research career has focused on understanding the pathophysiology of secondary degeneration following neurotrauma to the central nervous system (CNS). He uses innovative analytical techniques to demonstrate biochemical, molecular and gross anatomical changes that occur following CNS injury. Ryan has developed and optimised a combinatorial treatment strategy incorporating pharmacotherapeutics for the treatment of CNS injury. Ryan’s combinatorial strategy has been assessed in a clinically relevant model of spinal cord injury (SCI), demonstrating significant functional recovery and tissue sparing, crucial for the translation of his research into clinical trials.

In 2017, Ryan joined the SAHMRI Mind & Brain team in collaboration with Project Discovery and the Neil Sachse Centre for Spinal Cord Research, to provide his expertise in SCI and other neurotrauma models. Ryan looks to help develop new techniques to provide a more accurate diagnosis and prognosis of SCI, to identify potential treatment strategies in a clinical setting.

Education/Academic qualification

Bachelor's Degree, University of Western Australia

Bachelor's Degree (Honours), University of Western Australia

PhD, University of Western Australia

External positions

Project Manager, Project Discovery

9 Jan 201729 May 2020

Adjunct Lecturer, School of Medicine, The University of Adelaide, Adelaide, Australia.

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Research Output

  • 165 Citations
  • 7 h-Index
  • 9 Article
  • 1 Poster
  • 1 Review article

Acute cellular and functional changes with a combinatorial treatment of ion channel inhibitors following spinal cord injury

O'Hare Doig, R. L., Santhakumar, S., Fehily, B., Raja, S., Solomon, T., Bartlett, C. A., Fitzgerald, M. & Hodgetts, S. I., 2020, In : Frontiers in molecular neuroscience. 13, p. 85

Research output: Contribution to journalArticle

18-kDa translocator protein radioligand [18F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury

O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C., 2018.

Research output: Contribution to conferencePoster

Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors

Yates, N. J., Giacci, M., O'Hare Doig, R., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. & Fitzgerald, M., 1 Feb 2017, In : Neural Regeneration Research. 12, 2, p. 307-316 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma

O'Hare Doig, R. L., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In : BMC Neuroscience. 18, 1, 62.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro

O'Hare Doig, R. L., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M., 17 Dec 2016, In : Neuroscience. 339, p. 450-462 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Activities

  • 12 Editorial activity
  • 4 Membership of committee
  • 1 Organising a conference
  • 1 Membership of board

Australian Society of Molecular Imaging Symposium

Johan Verjans (Organiser), Sally E. Plush (Organiser), Ryan O'Hare Doig (Organiser), Patrick Hughes (Organiser), Nicole Dmochowska (Organiser), Marianne Keller (Organiser)
7 Nov 20198 Nov 2019

Activity: Participating in or organising an eventOrganising a conference

Life Sciences (Journal)

Ryan O'Hare Doig (Reviewer)
20182019

Activity: Publication peer-review and editorial workEditorial activity

International Journal of Peptide Research and Therapeutics (Journal)

Ryan O'Hare Doig (Reviewer)
20182019

Activity: Publication peer-review and editorial workEditorial activity

Translational Neuroscience (Journal)

Ryan O'Hare Doig (Reviewer)
20182019

Activity: Publication peer-review and editorial workEditorial activity