Research output per year
Research output per year
Personal profile
Research Interests
- Neurotrauma
- Neuropharmacology
- Molecular Biology
- Glia
- Oxidative stress
- Calcium dynamics
- Nuclear Imaging
- MRI
Public Profile
Ryan’s early research career has focused on understanding the pathophysiology of secondary degeneration following neurotrauma to the central nervous system (CNS). He uses innovative analytical techniques to demonstrate biochemical, molecular and gross anatomical changes that occur following CNS injury. Ryan has developed and optimised a combinatorial treatment strategy incorporating pharmacotherapeutics for the treatment of CNS injury. Ryan’s combinatorial strategy has been assessed in a clinically relevant model of spinal cord injury (SCI), demonstrating significant functional recovery and tissue sparing, crucial for the translation of his research into clinical trials.
In 2017, Ryan joined the SAHMRI Mind & Brain team in collaboration with Project Discovery and the Neil Sachse Centre for Spinal Cord Research, to provide his expertise in SCI and other neurotrauma models. Ryan looks to help develop new techniques to provide a more accurate diagnosis and prognosis of SCI, to identify potential treatment strategies in a clinical setting.
Education/Academic qualification
Bachelor's Degree, University of Western Australia
Bachelor's Degree (Honours), University of Western Australia
PhD, University of Western Australia
External positions
Project Manager, Project Discovery
9 Jan 2017 → 29 May 2020Adjunct Lecturer, School of Medicine, The University of Adelaide, Adelaide, Australia.
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Research output
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Acute cellular and functional changes with a combinatorial treatment of ion channel inhibitors following spinal cord injury
O'Hare Doig, R. L., Santhakumar, S., Fehily, B., Raja, S., Solomon, T., Bartlett, C. A., Fitzgerald, M. & Hodgetts, S. I., 2020, In: Frontiers in molecular neuroscience. 13, p. 85Research output: Contribution to journal › Article › peer-review
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18-kDa translocator protein radioligand [18F]GE-180 as a diagnostic and prognostic biomarker following spinal cord injury
O'Hare Doig, R., Lewis, M., Keller, M., Clark, J., Jones, C. & Freeman, B. J. C., 2018.Research output: Contribution to conference › Poster › peer-review
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Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors
Yates, N. J., Giacci, M., O'Hare Doig, R., Chiha, W., Ashworth, B. E., Kenna, J., Bartlett, C. & Fitzgerald, M., 1 Feb 2017, In: Neural Regeneration Research. 12, 2, p. 307-316 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma
O'Hare Doig, R. L., Chiha, W., Giacci, M. K., Yates, N. J., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Harvey, A. R. & Fitzgerald, M., 14 Aug 2017, In: BMC Neuroscience. 18, 1, 62.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro
O'Hare Doig, R. L., Bartlett, C. A., Smith, N. M., Hodgetts, S. I., Dunlop, S. A., Hool, L. & Fitzgerald, M., 17 Dec 2016, In: Neuroscience. 339, p. 450-462 13 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus)
Prizes
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Australian Postgraduate Award (Scholarship)
O'Hare Doig, Ryan (Recipient), 2013
Prize: Other distinction
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Activities
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Australian Society of Molecular Imaging Symposium
Johan Verjans (Organiser), Sally E. Plush (Organiser), Ryan O'Hare Doig (Organiser), Patrick Hughes (Organiser), Nicole Dmochowska (Organiser) & Marianne Keller (Organiser)
7 Nov 2019 → 8 Nov 2019Activity: Participating in or organising an event › Organising a conference
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Experimental Neurology (Journal)
Ryan O'Hare Doig (Reviewer)
2018 → …Activity: Publication peer-review and editorial work › Editorial activity
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National Neurotrauma Society (External organisation)
Ryan O'Hare Doig (Chair)
2018 → …Activity: Membership › Membership of committee
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Molecular and Cellular Neuroscience (Journal)
Ryan O'Hare Doig (Reviewer)
2018 → 2019Activity: Publication peer-review and editorial work › Editorial activity
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International Journal of Peptide Research and Therapeutics (Journal)
Ryan O'Hare Doig (Reviewer)
2018 → 2019Activity: Publication peer-review and editorial work › Editorial activity