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1974 …2019
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Research Output 1974 2019

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2019

A genome-wide knockout screen in human macrophages idetified host factors modulating Salmonella infection

Yeung, A. T. Y., Choi, Y. H., Lee, A. H. Y., Hale, C., Ponstingl, H., Pickard, D., Goulding, D., Thomas, M., Gill, E., Kim, J. K., Bradley, A., Hancock, R. & Dougana, G., 1 Jan 2019, In : mBio. 10, 5, e02169-19.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice

Wasan, E. K., Syeda, J., Strom, S., Cawthray, J., Hancock, R., Wasan, K. M. & Gerdts, V., 7 Mar 2019, In : Vaccine. 37, 11, p. 1503-1515 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections

Kumar, P., Pletzer, D., Haney, E. F., Rahanjam, N., Cheng, J. T. J., Yue, M., Aljehani, W., Hancock, R., Kizhakkedathu, J. N. & Straus, S. K., 8 Mar 2019, In : ACS Infectious Diseases. 5, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002

Wuerth, K., Lee, A. H. Y., Falsafi, R., Gill, E. E. & Hancock, R., 1 Jan 2019, In : Infection and Immunity. 87, 1, e00661.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Controlling biofilm formation with nitroxide functional surfaces

Woehlk, H., Trimble, M. J., Mansour, S. C., Pletzer, D., Trouillet, V., Welle, A., Barner, L., Hancock, R., Barner-Kowollik, C. & Fairfull-Smith, K. E., 21 Aug 2019, In : Polymer Chemistry. 10, 31, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

Dismantling the bacterial virulence program

Alford, M. A., Pletzer, D. & Hancock, R., 1 May 2019, In : Microbial Biotechnology. 12, 3, p. 409-413 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

The EPIC Consortium, 1 Dec 2019, In : Nature communications. 10, 1, 1092.

Research output: Contribution to journalArticle

Effect of Long-term Exposure to Peptides on Mono- and Multispecies Biofilms in Dentinal Tubules

Huang, X., Haapasalo, M., Wang, Z., Hancock, R., Wei, X. & Shen, Y., 1 Dec 2019, In : Journal of Endodontics. 45, 12, p. 1522-1528 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5

Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, T., Hancock, R. & Nielsen, H. M., 1 Aug 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity

Haney, E. F., Wuerth, K. C., Rahanjam, N., Nikouei, N. S., Ghassemi, A., Noghani, M. A., Boey, A. & Hancock, R., 1 Jan 2019, In : Peptide Science. 111, 1, e24077.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis

on behalf of the PedVas Investigators Network, 1 Oct 2019, In : Arthritis and Rheumatology. 71, 10, p. 1747-1755 9 p.

Research output: Contribution to journalArticle

Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides

Haney, E. F., Barbosa, S. C., Baquir, B. & Hancock, R., 27 Nov 2019, In : Journal of Medicinal Chemistry. 62, 22, p. 10294-10304 11 p.

Research output: Contribution to journalArticle

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Hussein, M., Han, M. L., Zhu, Y., Zhou, Q., Lin, Y. W., Hancock, R., Hoyer, D., Creek, D. J., Li, J. & Velkov, T., 14 Oct 2019, In : Antimicrobial Agents and Chemotherapy. 64, 1, e01587-19.

Research output: Contribution to journalArticle

24 Citations (Scopus)

NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis

Zhou, G., Soufan, O., Ewald, J., Hancock, R., Basu, N. & Xia, J., 2 Jul 2019, In : Nucleic acids research. 47, W1, p. W234-W241

Research output: Contribution to journalArticle

Outer membrane interaction kinetics of new polymyxin B analogs in Gram-negative bacilli

Akhoundsadegh, N., Belanger, C. R. & Hancock, R., 1 Jan 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, e00935-19.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential

Cândido, E. S., Cardoso, M. H., Chan, L. Y., Torres, M. D. T., Oshiro, K. G. N., Porto, W. F., Ribeiro, S. M., Haney, E. F., Hancock, R., Lu, T. K., De La Fuente-Nunez, C., Craik, D. J. & Franco, O. L., 24 Apr 2019, In : ACS Infectious Diseases. 5, 7, p. 1081-1086 6 p.

Research output: Contribution to journalArticle

2018
3 Citations (Scopus)

Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals

Wang, D., Shen, Y., Hancock, R., Ma, J. & Haapasalo, M., 1 Nov 2018, In : Journal of Endodontics. 44, 11, p. 1709-1713 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Bone environment influences irreversible adhesion of a methicillin-susceptible staphylococcus aureus strain

Reffuveille, F., Josse, J., Velard, F., Lamret, F., Varin-Simon, J., Dubus, M., Haney, E. F., Hancock, R., Mongaret, C. & Gangloff, S. C., 27 Nov 2018, In : Frontiers in Microbiology. 9, NOV, 2865.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Broad-spectrum adaptive antibiotic resistance associated with pseudomonas aeruginosa mucin-dependent surfing motility

Sun, E., Gill, E. E., Falsafi, R., Yeung, A., Liu, S. & Hancock, R., 1 Sep 2018, In : Antimicrobial Agents and Chemotherapy. 62, 9, e00848-18.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms

Haney, E. F., Brito-Sánchez, Y., Trimble, M. J., Mansour, S. C., Cherkasov, A. & Hancock, R., 1 Dec 2018, In : Scientific Reports. 8, 1, 1871.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides

Haney, E. F., Trimble, M. J., Cheng, J. T., Vallé, Q. & Hancock, R., 1 Jun 2018, In : Biomolecules. 8, 2, 29.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Development of Molecularly Imprinted Polymers to Block Quorum Sensing and Inhibit Bacterial Biofilm Formation

Ma, L., Feng, S., Fuente-Núñez, C. D. L., Hancock, R. & Lu, X., 6 Jun 2018, In : ACS Applied Materials and Interfaces. 10, 22, p. 18450-18457 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Helicobacter pylori biofilm formation is differentially affected by common culture conditions, and proteins play a central role in the biofilm matrix

Windham, I. H., Servetas, S. L., Whitmire, J. M., Pletzer, D., Hancock, R. & Merrell, D. S., 1 Jul 2018, In : Applied and Environmental Microbiology. 84, 14, e00391-18.

Research output: Contribution to journalArticle

5 Citations (Scopus)

High-throughput detection of RNA processing in bacteria

Gill, E. E., Chan, L. S., Winsor, G. L., Dobson, N., Lo, R., Ho Sui, S. J., Dhillon, B. K., Taylor, P. K., Shrestha, R., Spencer, C., Hancock, R., Unrau, P. J. & Brinkman, F. S. L., 27 Mar 2018, In : BMC Genomics. 19, 1, 223.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment

Marin-Luevano, P., Trujillo, V., Rodriguez-Carlos, A., González-Curiel, I., Enciso-Moreno, J. A., Hancock, R. & Rivas-Santiago, B., 1 Mar 2018, In : Peptides. 101, p. 135-144 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Porto, W. F., Irazazabal, L., Alves, E. S. F., Ribeiro, S. M., Matos, C. O., Pires, Á. S., Fensterseifer, I. C. M., Miranda, V. J., Haney, E. F., Humblot, V., Torres, M. D. T., Hancock, R., Liao, L. M., Ladram, A., Lu, T. K., De La Fuente-Nunez, C. & Franco, O. L., 1 Dec 2018, In : Nature communications. 9, 1, 1490.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

Forbester, J. L., Lees, E. A., Goulding, D., Forrest, S., Yeung, A., Speak, A., Clare, S., Coomber, E. L., Mukhopadhyay, S., Kraiczy, J., Schreiber, F., Lawley, T. D., Hancock, R., Uhlig, H. H., Zilbauer, M., Powrie, F. & Dougan, G., 2 Oct 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 10118-10123 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin

Wolfmeier, H., Mansour, S. C., Liu, L. T., Pletzer, D., Draeger, A., Babiychuk, E. B. & Hancock, R., 1 Jul 2018, In : EBioMedicine. 33, p. 211-217 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MetaBridge: Enabling network-based integrative analysis via direct protein interactors of metabolites

Hinshaw, S. J., Lee, A. H. Y., Gill, E. E. & Hancock, R., 1 Jan 2018, In : Bioinformatics. 34, 18, p. 3225-3227 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines

Mwanza-Lisulo, M., Chomba, M. S., Chama, M., Besa, E. C., Funjika, E., Zyambo, K., Banda, R., Imikendu, M., Sianongo, S., Hancock, R., Lee, A., Chilengi, R., Stagg, A. J., Namangala, B. & Kelly, P. M., 27 Jun 2018, In : Vaccine. 36, 28, p. 4134-4141 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Surfing motility: A conserved yet diverse adaptation among motile bacteria

Sun, E., Liu, S. & Hancock, R., 1 Dec 2018, In : Journal of bacteriology. 200, 23, e00394.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

Pletzer, D., Mansour, S. C. & Hancock, R., 1 Jun 2018, In : PLoS Pathogens. 14, 6, e1007084.

Research output: Contribution to journalArticle

2017
10 Citations (Scopus)

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides

Haney, E. F., Wu, B. C., Lee, K., Hilchie, A. L. & Hancock, R., 17 Aug 2017, In : Cell Chemical Biology. 24, 8, p. 969-980.e4

Research output: Contribution to journalArticle

8 Citations (Scopus)

An immunomodulatory peptide confers protection in an experimental candidemia murine model

Freitas, C. G., Lima, S. M. F., Freire, M. S., Cantuária, A. P. C., Júnior, N. G. O., Santos, T. S., Folha, J. S., Ribeiro, S. M., Dias, S. C., Rezende, T. M. B., Albuquerque, P., Nicola, A. M., De La Fuente-Núñez, C., Hancock, R., Franco, O. L. & Felipe, M. S. S., 1 Aug 2017, In : Antimicrobial Agents and Chemotherapy. 61, 8, e02518.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa

Taylor, P. K., Van Kessel, A. T. M., Colavita, A., Hancock, R. & Mah, T. F., 1 Aug 2017, In : PLoS ONE. 12, 8, e0182582.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

Yu, K., Lo, J. C. Y., Yan, M., Yang, X., Brooks, D. E., Hancock, R., Lange, D. & Kizhakkedathu, J. N., 1 Feb 2017, In : Biomaterials. 116, p. 69-81 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro

Wang, D., Shen, Y., Ma, J., Hancock, R. & Haapasalo, M., 1 Nov 2017, In : Journal of Endodontics. 43, 11, p. 1862-1867 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Anticancer activities of bovine and human lactoferricin-derived peptides1

Arias, M., Hilchie, A. L., Haney, E. F., Bolscher, J. G. M., Hyndman, M. E., Hancock, R. & Vogel, H. J., 1 Jan 2017, In : Biochemistry and Cell Biology. 95, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum

Crabbé, A., Liu, Y., Matthijs, N., Rigole, P., De La Fuente-Nùñez, C., Davis, R., Ledesma, M. A., Sarker, S., Van Houdt, R., Hancock, R., Coenye, T. & Nickerson, C. A., 3 Mar 2017, In : Scientific Reports. 7, 43321.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Ciprofloxacin-nitroxide hybrids with potential for biofilm control

Verderosa, A. D., de la Fuente-Núñez, C., Mansour, S. C., Cao, J., Lu, T. K., Hancock, R. & Fairfull-Smith, K. E., 1 Jan 2017, In : European Journal of Medicinal Chemistry. 138, p. 590-601 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

Yeung, A. T. Y., Hale, C., Lee, A. H., Gill, E. E., Bushell, W., Parry-Smith, D., Goulding, D., Pickard, D., Roumeliotis, T., Choudhary, J., Thomson, N., Skarnes, W. C., Dougan, G. & Hancock, R., 1 Jan 2017, In : Nature communications. 8, 15013.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Mechanisms of the innate defense regulator peptide-1002 anti-inflammatory activity in a sterile inflammation mouse model

Wu, B. C., Lee, A. H. Y. & Hancock, R., 15 Nov 2017, In : Journal of Immunology. 199, 10, p. 3592-3603 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

New mouse model for chronic infections by gram-negative bacteria enabling the study of anti-infective efficacy and host-microbe interactions

Pletzer, D., Mansour, S. C., Wuerth, K., Rahanjam, N. & Hancock, R., 1 Jan 2017, In : mBio. 8, 1, e00140-17.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Sensing Mg2+ contributes to the resistance of Pseudomonas aeruginosa to complement-mediated opsonophagocytosis

Qadi, M., Izquierdo-Rabassa, S., Mateu Borrás, M., Doménech-Sánchez, A., Juan, C., Goldberg, J. B., Hancock, R. & Albertí, S., 1 Oct 2017, In : Environmental Microbiology. 19, 10, p. 4278-4286 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection

Wuerth, K. C., Falsafi, R. & Hancock, R., 1 Nov 2017, In : PloS one. 12, 11, e0187565.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Synthetic peptides to target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model

Pletzer, D., Wolfmeier, H., Bains, M. & Hancock, R., 27 Sep 2017, In : Frontiers in Microbiology. 8, SEP, 1867.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology

Hall, B. M., Breidenstein, E. B. M., de la Fuente-Núñez, C., Reffuveille, F., Mawla, G. D., Hancock, R. & Baker, T. A., 1 Jan 2017, In : Journal of bacteriology. 199, 3, e00568-16.

Research output: Contribution to journalArticle

2016
43 Citations (Scopus)

An anti-infective synthetic peptide with dual antimicrobial and immunomodulatory activities

Silva, O. N., De La Fuente-Núñez, C., Haney, E. F., Fensterseifer, I. C. M., Ribeiro, S. M., Porto, W. F., Brown, P., Faria-Junior, C., Rezende, T. M. B., Moreno, S. E., Lu, T. K., Hancock, R. & Franco, O. L., 2 Nov 2016, In : Scientific Reports. 6, 35465.

Research output: Contribution to journalArticle

25 Citations (Scopus)

A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells

Pane, K., Sgambati, V., Zanfardino, A., Smaldone, G., Cafaro, V., Angrisano, T., Pedone, E., Di Gaetano, S., Capasso, D., Haney, E. F., Izzo, V., Varcamonti, M., Notomista, E., Hancock, R., Di Donato, A. & Pizzo, E., 1 Jun 2016, In : FEBS Journal. 283, 11, p. 2115-2131 17 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A polyalanine peptide derived from polar fish with anti-infectious activities

Cardoso, M. H., Ribeiro, S. M., Nolasco, D. O., De La Fuente-Núñez, C., Felício, M. R., Gonçalves, S., Matos, C. O., Liao, L. M., Santos, N. C., Hancock, R., Franco, O. L. & Migliolo, L., 26 Feb 2016, In : Scientific Reports. 6, 21385.

Research output: Contribution to journalArticle