• 63258 Citations
  • 126 h-Index
1974 …2019
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Research Output 1974 2019

2019

A genome-wide knockout screen in human macrophages idetified host factors modulating Salmonella infection

Yeung, A. T. Y., Choi, Y. H., Lee, A. H. Y., Hale, C., Ponstingl, H., Pickard, D., Goulding, D., Thomas, M., Gill, E., Kim, J. K., Bradley, A., Hancock, R. & Dougana, G., 1 Jan 2019, In : mBio. 10, 5, e02169-19.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice

Wasan, E. K., Syeda, J., Strom, S., Cawthray, J., Hancock, R., Wasan, K. M. & Gerdts, V., 7 Mar 2019, In : Vaccine. 37, 11, p. 1503-1515 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections

Kumar, P., Pletzer, D., Haney, E. F., Rahanjam, N., Cheng, J. T. J., Yue, M., Aljehani, W., Hancock, R., Kizhakkedathu, J. N. & Straus, S. K., 8 Mar 2019, In : ACS Infectious Diseases. 5, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002

Wuerth, K., Lee, A. H. Y., Falsafi, R., Gill, E. E. & Hancock, R., 1 Jan 2019, In : Infection and Immunity. 87, 1, e00661.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Controlling biofilm formation with nitroxide functional surfaces

Woehlk, H., Trimble, M. J., Mansour, S. C., Pletzer, D., Trouillet, V., Welle, A., Barner, L., Hancock, R., Barner-Kowollik, C. & Fairfull-Smith, K. E., 21 Aug 2019, In : Polymer Chemistry. 10, 31, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application

Dostert, M., Belanger, C. R. & Hancock, R., 1 Apr 2019, In : Journal of Innate Immunity. 11, 3, p. 193-204 12 p.

Research output: Contribution to journalReview article

Dismantling the bacterial virulence program

Alford, M. A., Pletzer, D. & Hancock, R., 1 May 2019, In : Microbial Biotechnology. 12, 3, p. 409-413 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

The EPIC Consortium, 1 Dec 2019, In : Nature communications. 10, 1, 1092.

Research output: Contribution to journalArticle

Effect of Long-term Exposure to Peptides on Mono- and Multispecies Biofilms in Dentinal Tubules

Huang, X., Haapasalo, M., Wang, Z., Hancock, R., Wei, X. & Shen, Y., 1 Dec 2019, In : Journal of Endodontics. 45, 12, p. 1522-1528 7 p.

Research output: Contribution to journalArticle

Host defense peptides in fish: From the peculiar to the mainstream

Patrzykat, A. & Hancock, R., 1 Jan 2019, Fish Defenses: Volume 2: Pathogens, Parasites and Predators. CRC Press, p. 43-61 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5

Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, T., Hancock, R. & Nielsen, H. M., 1 Aug 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity

Haney, E. F., Wuerth, K. C., Rahanjam, N., Nikouei, N. S., Ghassemi, A., Noghani, M. A., Boey, A. & Hancock, R., 1 Jan 2019, In : Peptide Science. 111, 1, e24077.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis

on behalf of the PedVas Investigators Network, 1 Oct 2019, In : Arthritis and Rheumatology. 71, 10, p. 1747-1755 9 p.

Research output: Contribution to journalArticle

Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides

Haney, E. F., Barbosa, S. C., Baquir, B. & Hancock, R., 27 Nov 2019, In : Journal of Medicinal Chemistry. 62, 22, p. 10294-10304 11 p.

Research output: Contribution to journalArticle

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Hussein, M., Han, M. L., Zhu, Y., Zhou, Q., Lin, Y. W., Hancock, R., Hoyer, D., Creek, D. J., Li, J. & Velkov, T., 14 Oct 2019, In : Antimicrobial Agents and Chemotherapy. 64, 1, e01587-19.

Research output: Contribution to journalArticle

24 Citations (Scopus)

NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis

Zhou, G., Soufan, O., Ewald, J., Hancock, R., Basu, N. & Xia, J., 2 Jul 2019, In : Nucleic acids research. 47, W1, p. W234-W241

Research output: Contribution to journalArticle

Outer membrane interaction kinetics of new polymyxin B analogs in Gram-negative bacilli

Akhoundsadegh, N., Belanger, C. R. & Hancock, R., 1 Jan 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, e00935-19.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Reassessing the host defense peptide landscape

Haney, E. F., Straus, S. K. & Hancock, R., 1 Jan 2019, In : Frontiers in Chemistry. 7, FEB, 43.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential

Cândido, E. S., Cardoso, M. H., Chan, L. Y., Torres, M. D. T., Oshiro, K. G. N., Porto, W. F., Ribeiro, S. M., Haney, E. F., Hancock, R., Lu, T. K., De La Fuente-Nunez, C., Craik, D. J. & Franco, O. L., 24 Apr 2019, In : ACS Infectious Diseases. 5, 7, p. 1081-1086 6 p.

Research output: Contribution to journalArticle

2018
3 Citations (Scopus)

Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals

Wang, D., Shen, Y., Hancock, R., Ma, J. & Haapasalo, M., 1 Nov 2018, In : Journal of Endodontics. 44, 11, p. 1709-1713 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Bone environment influences irreversible adhesion of a methicillin-susceptible staphylococcus aureus strain

Reffuveille, F., Josse, J., Velard, F., Lamret, F., Varin-Simon, J., Dubus, M., Haney, E. F., Hancock, R., Mongaret, C. & Gangloff, S. C., 27 Nov 2018, In : Frontiers in Microbiology. 9, NOV, 2865.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Broad-spectrum adaptive antibiotic resistance associated with pseudomonas aeruginosa mucin-dependent surfing motility

Sun, E., Gill, E. E., Falsafi, R., Yeung, A., Liu, S. & Hancock, R., 1 Sep 2018, In : Antimicrobial Agents and Chemotherapy. 62, 9, e00848-18.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms

Haney, E. F., Brito-Sánchez, Y., Trimble, M. J., Mansour, S. C., Cherkasov, A. & Hancock, R., 1 Dec 2018, In : Scientific Reports. 8, 1, 1871.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides

Haney, E. F., Trimble, M. J., Cheng, J. T., Vallé, Q. & Hancock, R., 1 Jun 2018, In : Biomolecules. 8, 2, 29.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Development of Molecularly Imprinted Polymers to Block Quorum Sensing and Inhibit Bacterial Biofilm Formation

Ma, L., Feng, S., Fuente-Núñez, C. D. L., Hancock, R. & Lu, X., 6 Jun 2018, In : ACS Applied Materials and Interfaces. 10, 22, p. 18450-18457 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Helicobacter pylori biofilm formation is differentially affected by common culture conditions, and proteins play a central role in the biofilm matrix

Windham, I. H., Servetas, S. L., Whitmire, J. M., Pletzer, D., Hancock, R. & Merrell, D. S., 1 Jul 2018, In : Applied and Environmental Microbiology. 84, 14, e00391-18.

Research output: Contribution to journalArticle

5 Citations (Scopus)

High-throughput detection of RNA processing in bacteria

Gill, E. E., Chan, L. S., Winsor, G. L., Dobson, N., Lo, R., Ho Sui, S. J., Dhillon, B. K., Taylor, P. K., Shrestha, R., Spencer, C., Hancock, R., Unrau, P. J. & Brinkman, F. S. L., 27 Mar 2018, In : BMC Genomics. 19, 1, 223.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Host defense (antimicrobial) peptides

Sun, E., Belanger, C. R., Haney, E. F. & Hancock, R., 1 Jan 2018, Peptide Applications in Biomedicine, Biotechnology and Bioengineering. Elsevier Inc., p. 253-285 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment

Marin-Luevano, P., Trujillo, V., Rodriguez-Carlos, A., González-Curiel, I., Enciso-Moreno, J. A., Hancock, R. & Rivas-Santiago, B., 1 Mar 2018, In : Peptides. 101, p. 135-144 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

In silico optimization of a guava antimicrobial peptide enables combinatorial exploration for peptide design

Porto, W. F., Irazazabal, L., Alves, E. S. F., Ribeiro, S. M., Matos, C. O., Pires, Á. S., Fensterseifer, I. C. M., Miranda, V. J., Haney, E. F., Humblot, V., Torres, M. D. T., Hancock, R., Liao, L. M., Ladram, A., Lu, T. K., De La Fuente-Nunez, C. & Franco, O. L., 1 Dec 2018, In : Nature communications. 9, 1, 1490.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

Forbester, J. L., Lees, E. A., Goulding, D., Forrest, S., Yeung, A., Speak, A., Clare, S., Coomber, E. L., Mukhopadhyay, S., Kraiczy, J., Schreiber, F., Lawley, T. D., Hancock, R., Uhlig, H. H., Zilbauer, M., Powrie, F. & Dougan, G., 2 Oct 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 40, p. 10118-10123 6 p.

Research output: Contribution to journalArticle

Is synergy the key to treating high-density infections?

Pletzer, D. & Hancock, R., 1 Nov 2018, In : Future Microbiology. 13, 15, p. 1629-1632 4 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Liposomal Therapy Attenuates Dermonecrosis Induced by Community-Associated Methicillin-Resistant Staphylococcus aureus by Targeting α-Type Phenol-Soluble Modulins and α-Hemolysin

Wolfmeier, H., Mansour, S. C., Liu, L. T., Pletzer, D., Draeger, A., Babiychuk, E. B. & Hancock, R., 1 Jul 2018, In : EBioMedicine. 33, p. 211-217 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MetaBridge: Enabling network-based integrative analysis via direct protein interactors of metabolites

Hinshaw, S. J., Lee, A. H. Y., Gill, E. E. & Hancock, R., 1 Jan 2018, In : Bioinformatics. 34, 18, p. 3225-3227 3 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

New Perspectives in Biofilm Eradication

Wolfmeier, H., Pletzer, D., Mansour, S. C. & Hancock, R., 9 Feb 2018, In : ACS Infectious Diseases. 4, 2, p. 93-106 14 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines

Mwanza-Lisulo, M., Chomba, M. S., Chama, M., Besa, E. C., Funjika, E., Zyambo, K., Banda, R., Imikendu, M., Sianongo, S., Hancock, R., Lee, A., Chilengi, R., Stagg, A. J., Namangala, B. & Kelly, P. M., 27 Jun 2018, In : Vaccine. 36, 28, p. 4134-4141 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Surfing motility: A conserved yet diverse adaptation among motile bacteria

Sun, E., Liu, S. & Hancock, R., 1 Dec 2018, In : Journal of bacteriology. 200, 23, e00394.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens

Pletzer, D., Mansour, S. C. & Hancock, R., 1 Jun 2018, In : PLoS Pathogens. 14, 6, e1007084.

Research output: Contribution to journalArticle

2017
10 Citations (Scopus)

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides

Haney, E. F., Wu, B. C., Lee, K., Hilchie, A. L. & Hancock, R., 17 Aug 2017, In : Cell Chemical Biology. 24, 8, p. 969-980.e4

Research output: Contribution to journalArticle

2 Citations (Scopus)

An alternative approach to treating antibiotic-resistant infections

Trimble, M. J. & Hancock, R., 1 Mar 2017, In : Future Microbiology. 12, 3, p. 201-204 4 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

An immunomodulatory peptide confers protection in an experimental candidemia murine model

Freitas, C. G., Lima, S. M. F., Freire, M. S., Cantuária, A. P. C., Júnior, N. G. O., Santos, T. S., Folha, J. S., Ribeiro, S. M., Dias, S. C., Rezende, T. M. B., Albuquerque, P., Nicola, A. M., De La Fuente-Núñez, C., Hancock, R., Franco, O. L. & Felipe, M. S. S., 1 Aug 2017, In : Antimicrobial Agents and Chemotherapy. 61, 8, e02518.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa

Taylor, P. K., Van Kessel, A. T. M., Colavita, A., Hancock, R. & Mah, T. F., 1 Aug 2017, In : PLoS ONE. 12, 8, e0182582.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

Yu, K., Lo, J. C. Y., Yan, M., Yang, X., Brooks, D. E., Hancock, R., Lange, D. & Kizhakkedathu, J. N., 1 Feb 2017, In : Biomaterials. 116, p. 69-81 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro

Wang, D., Shen, Y., Ma, J., Hancock, R. & Haapasalo, M., 1 Nov 2017, In : Journal of Endodontics. 43, 11, p. 1862-1867 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Anticancer activities of bovine and human lactoferricin-derived peptides1

Arias, M., Hilchie, A. L., Haney, E. F., Bolscher, J. G. M., Hyndman, M. E., Hancock, R. & Vogel, H. J., 1 Jan 2017, In : Biochemistry and Cell Biology. 95, 1, p. 91-98 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum

Crabbé, A., Liu, Y., Matthijs, N., Rigole, P., De La Fuente-Nùñez, C., Davis, R., Ledesma, M. A., Sarker, S., Van Houdt, R., Hancock, R., Coenye, T. & Nickerson, C. A., 3 Mar 2017, In : Scientific Reports. 7, 43321.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Antimicrobial peptides: An introduction

Haney, E. F., Mansour, S. C. & Hancock, R., 1 Jan 2017, Methods in Molecular Biology. Humana Press Inc., p. 3-22 20 p. (Methods in Molecular Biology; vol. 1548).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Ciprofloxacin-nitroxide hybrids with potential for biofilm control

Verderosa, A. D., de la Fuente-Núñez, C., Mansour, S. C., Cao, J., Lu, T. K., Hancock, R. & Fairfull-Smith, K. E., 1 Jan 2017, In : European Journal of Medicinal Chemistry. 138, p. 590-601 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Exosomes, your body's answer to immune health

Baquir, B. & Hancock, R., 1 Feb 2017, In : Annals of Translational Medicine. 5, 4, 81.

Research output: Contribution to journalEditorial

17 Citations (Scopus)

Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis

Yeung, A. T. Y., Hale, C., Lee, A. H., Gill, E. E., Bushell, W., Parry-Smith, D., Goulding, D., Pickard, D., Roumeliotis, T., Choudhary, J., Thomson, N., Skarnes, W. C., Dougan, G. & Hancock, R., 1 Jan 2017, In : Nature communications. 8, 15013.

Research output: Contribution to journalArticle