• 67024 Citations
  • 130 h-Index
1974 …2020

Research output per year

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Research Output

2020

AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria

McDaniel, C. T., Panmanee, W., Winsor, G. L., Gill, E., Bertelli, C., Schurr, M. J., Dongare, P., Paul, A. T., Ko, S. H. B., Lau, G. W., Dasgupta, N., Bogue, A. L., Miller, W. E., Mortensen, J. E., Haslam, D. B., Dexheimer, P., Muruve, D. A., Aronow, B. J., Forbes, M. D. E., Danilczuk, M. & 4 others, Brinkman, F. S. L., Hancock, R. E. W., Meyer, T. J. & Hassett, D. J., 3 Mar 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 9, p. 4921-4930 10 p.

Research output: Contribution to journalArticle

Bacterial Aggregation Triggered by Fibril Forming Tryptophan-Rich Sequences: Effects of Peptide Side Chain and Membrane Phospholipids

Bagheri, M., Nikolenko, H., Arasteh, S., Rezaei, N., Behzadi, M., Dathe, M. & Hancock, R. E. W., 17 Jun 2020, In : ACS applied materials & interfaces. 12, 24, p. 26852-26867 16 p.

Research output: Contribution to journalArticle

EcDBS1R6: A novel cationic antimicrobial peptide derived from a signal peptide sequence

Porto, W. F., Irazazabal, L. N., Humblot, V., Haney, E. F., Ribeiro, S. M., Hancock, R. E. W., Ladram, A. & Franco, O. L., Sep 2020, In : Biochimica et Biophysica Acta - General Subjects. 1864, 9, 129633.

Research output: Contribution to journalArticle

Insights into the mechanism of action of two analogues of aurein 2.2

Raheem, N., Kumar, P., Lee, E., Cheng, J. T. J., Hancock, R. E. W. & Straus, S. K., 1 Jun 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 183262.

Research output: Contribution to journalArticle

2 Citations (Scopus)

In vitro and in vivo antibiotic capacity of two host defense peptides

Arenas, I., Ibarra, M. A., Santana, F. L., Villegas, E., Hancock, R. E. W. & Corzo, G., Jul 2020, In : Antimicrobial Agents and Chemotherapy. 64, 7, e00145-20.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ivacaftor or lumacaftor/ivacaftor treatment does not alter the core CF airway epithelial gene response to rhinovirus

WAERP, 1 Jan 2020, (Accepted/In press) In : Journal of Cystic Fibrosis.

Research output: Contribution to journalArticle

MetaBridge: An Integrative Multi-Omics Tool for Metabolite-Enzyme Mapping

Blimkie, T., Lee, A. H. Y. & Hancock, R., 1 Jun 2020, In : Current protocols in bioinformatics. 70, 1, p. e98

Research output: Contribution to journalArticle

Multidrug adaptive resistance of Pseudomonas aeruginosa swarming cells

Coleman, S. R., Blimkie, T., Falsafi, R. & Hancock, R., 1 Jan 2020, In : Antimicrobial Agents and Chemotherapy. 64, 3, e01999-19.

Research output: Contribution to journalArticle

2 Citations (Scopus)

NtrBC Regulates Invasiveness and Virulence of Pseudomonas aeruginosa During High-Density Infection

Alford, M. A., Baghela, A., Yeung, A. T. Y., Pletzer, D. & Hancock, R. E. W., 5 May 2020, In : Frontiers in Microbiology. 11, 773.

Research output: Contribution to journalArticle

Open Access

Overexpression of the small RNA pa0805.1 in Pseudomonas aeruginosa modulates the expression of a large set of genes and proteins, resulting in altered motility, cytotoxicity, and tobramycin resistance

Coleman, S. R., Smith, M. L., Spicer, V., Lao, Y., Mookherjee, N. & Hancock, R. E. W., Jun 2020, In : mSystems. 5, 3, e00204-20.

Research output: Contribution to journalArticle

Open Access

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis

ARESTCF, WAERP & AusREC, 16 Jul 2020, In : Frontiers in Immunology. 11, 1327.

Research output: Contribution to journalArticle

Open Access

Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin

Arias, M., Haney, E. F., Hilchie, A. L., Corcoran, J. A., Hyndman, M. E., Hancock, R. E. W. & Vogel, H. J., 1 Jan 2020, In : Biochimica et Biophysica Acta - Biomembranes. 183228.

Research output: Contribution to journalArticle

Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58

Pletzer, D., Sun, E., Ritchie, C., Wilkinson, L., Liu, L. T., Trimble, M. J., Wolfmeier, H., Blimkie, T. M. & Hancock, R. E. W., 1 Jan 2020, In : PLoS Pathogens. 16, 3, e1008444.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Systems Biology Approaches to Understanding the Human Immune System

Dhillon, B. K., Smith, M., Baghela, A., Lee, A. H. Y. & Hancock, R. E. W., 30 Jul 2020, In : Frontiers in Immunology. 11, 1683.

Research output: Contribution to journalArticle

Open Access

The importance of reporting house dust mite endotoxin abundance: Impact on the lung transcriptome

Canadian Respiratory Research Network, Jun 2020, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 6, p. L1229-L1236

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The value of antimicrobial peptides in the age of resistance

Magana, M., Pushpanathan, M., Santos, A. L., Leanse, L., Fernandez, M., Ioannidis, A., Giulianotti, M. A., Apidianakis, Y., Bradfute, S., Ferguson, A. L., Cherkasov, A., Seleem, M. N., Pinilla, C., de la Fuente-Nunez, C., Lazaridis, T., Dai, T., Houghten, R. A., Hancock, R. E. W. & Tegos, G. P., Sep 2020, In : The Lancet Infectious Diseases. 20, 9, p. e216-e230

Research output: Contribution to journalReview article

4 Citations (Scopus)

Unique inducible filamentous motility identified in pathogenic Bacillus cereus group species

Liu, M. M., Coleman, S., Wilkinson, L., Smith, M. L., Hoang, T., Niyah, N., Mukherjee, M., Huynh, S., Parker, C. T., Kovac, J., Hancock, R. E. W. & Gaynor, E. C., 1 Jan 2020, (Accepted/In press) In : ISME Journal.

Research output: Contribution to journalArticle

Open Access

Utilizing Organoid and Air-Liquid Interface Models as a Screening Method in the Development of New Host Defense Peptides

Choi, K. Y. G., Wu, B. C., Lee, A. H. Y., Baquir, B. & Hancock, R. E. W., 20 May 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 228.

Research output: Contribution to journalReview article

Open Access

Whole blood transcriptional responses of very preterm infants during late-onset sepsis

Ng, S., Strunk, T., Lee, A. H., Gill, E. E., Falsafi, R., Woodman, T., Hibbert, J., Hancock, R. E. W. & Currie, A., 1 Jun 2020, In : PloS one. 15, 6, e0233841.

Research output: Contribution to journalArticle

Open Access
2019

A genome-wide knockout screen in human macrophages idetified host factors modulating Salmonella infection

Yeung, A. T. Y., Choi, Y. H., Lee, A. H. Y., Hale, C., Ponstingl, H., Pickard, D., Goulding, D., Thomas, M., Gill, E., Kim, J. K., Bradley, A., Hancock, R. E. W. & Dougana, G., 1 Oct 2019, In : mBio. 10, 5, e02169-19.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice

Wasan, E. K., Syeda, J., Strom, S., Cawthray, J., Hancock, R. E., Wasan, K. M. & Gerdts, V., 7 Mar 2019, In : Vaccine. 37, 11, p. 1503-1515 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Aurein-Derived Antimicrobial Peptides Formulated with Pegylated Phospholipid Micelles to Target Methicillin-Resistant Staphylococcus aureus Skin Infections

Kumar, P., Pletzer, D., Haney, E. F., Rahanjam, N., Cheng, J. T. J., Yue, M., Aljehani, W., Hancock, R., Kizhakkedathu, J. N. & Straus, S. K., 8 Mar 2019, In : ACS Infectious Diseases. 5, 3, p. 443-453 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
6 Citations (Scopus)

Controlling biofilm formation with nitroxide functional surfaces

Woehlk, H., Trimble, M. J., Mansour, S. C., Pletzer, D., Trouillet, V., Welle, A., Barner, L., Hancock, R. E. W., Barner-Kowollik, C. & Fairfull-Smith, K. E., 21 Aug 2019, In : Polymer Chemistry. 10, 31, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application

Dostert, M., Belanger, C. R. & Hancock, R. E. W., 1 Apr 2019, In : Journal of Innate Immunity. 11, 3, p. 193-204 12 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Dismantling the bacterial virulence program

Alford, M. A., Pletzer, D. & Hancock, R. E. W., May 2019, In : Microbial Biotechnology. 12, 3, p. 409-413 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

The EPIC Consortium, 1 Dec 2019, In : Nature Communications. 10, 1, 1092.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Effect of Long-term Exposure to Peptides on Mono- and Multispecies Biofilms in Dentinal Tubules

Huang, X., Haapasalo, M., Wang, Z., Hancock, R., Wei, X. & Shen, Y., 1 Dec 2019, In : Journal of Endodontics. 45, 12, p. 1522-1528 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Host defense peptides in fish: From the peculiar to the mainstream

Patrzykat, A. & Hancock, R. E. W., 1 Jan 2019, Fish Defenses: Volume 2: Pathogens, Parasites and Predators. CRC Press, p. 43-61 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Host defense peptides in fish: From the peculiar to the mainstream

Patrzykat, A. & Hancock, R., 1 Jan 2019, Fish Defenses: Volume 2: Pathogens, Parasites and Predators. CRC Press, p. 43-61 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5

Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, T., Hancock, R. & Nielsen, H. M., 1 Aug 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity

Haney, E. F., Wuerth, K. C., Rahanjam, N., Nikouei, N. S., Ghassemi, A., Noghani, M. A., Boey, A. & Hancock, R. E. W., 1 Jan 2019, In : Peptide Science. 111, 1, e24077.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis

on behalf of the PedVas Investigators Network, 1 Oct 2019, In : Arthritis and Rheumatology. 71, 10, p. 1747-1755 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides

Haney, E. F., Barbosa, S. C., Baquir, B. & Hancock, R. E. W., 27 Nov 2019, In : Journal of Medicinal Chemistry. 62, 22, p. 10294-10304 11 p.

Research output: Contribution to journalArticle

Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa

Hussein, M., Han, M. L., Zhu, Y., Zhou, Q., Lin, Y. W., Hancock, R. E. W., Hoyer, D., Creek, D. J., Li, J. & Velkov, T., 14 Oct 2019, In : Antimicrobial Agents and Chemotherapy. 64, 1, e01587-19.

Research output: Contribution to journalArticle

2 Citations (Scopus)

NetworkAnalyst 3.0: A visual analytics platform for comprehensive gene expression profiling and meta-analysis

Zhou, G., Soufan, O., Ewald, J., Hancock, R. E. W., Basu, N. & Xia, J., 1 Jul 2019, In : Nucleic Acids Research. 47, W1, p. W234-W241

Research output: Contribution to journalArticle

85 Citations (Scopus)

Outer membrane interaction kinetics of new polymyxin B analogs in Gram-negative bacilli

Akhoundsadegh, N., Belanger, C. R. & Hancock, R., 22 Jul 2019, In : Antimicrobial Agents and Chemotherapy. 63, 10, e00935-19.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Reassessing the host defense peptide landscape

Haney, E. F., Straus, S. K. & Hancock, R., 4 Feb 2019, In : Frontiers in Chemistry. 7, FEB, 43.

Research output: Contribution to journalReview article

60 Citations (Scopus)

Short Cationic Peptide Derived from Archaea with Dual Antibacterial Properties and Anti-Infective Potential

Cândido, E. S., Cardoso, M. H., Chan, L. Y., Torres, M. D. T., Oshiro, K. G. N., Porto, W. F., Ribeiro, S. M., Haney, E. F., Hancock, R. E. W., Lu, T. K., De La Fuente-Nunez, C., Craik, D. J. & Franco, O. L., 24 Apr 2019, In : ACS Infectious Diseases. 5, 7, p. 1081-1086 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals

Wang, D., Shen, Y., Hancock, R., Ma, J. & Haapasalo, M., 1 Nov 2018, In : Journal of Endodontics. 44, 11, p. 1709-1713 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Bone environment influences irreversible adhesion of a methicillin-susceptible staphylococcus aureus strain

Reffuveille, F., Josse, J., Velard, F., Lamret, F., Varin-Simon, J., Dubus, M., Haney, E. F., Hancock, R. E. W., Mongaret, C. & Gangloff, S. C., 27 Nov 2018, In : Frontiers in Microbiology. 9, NOV, 2865.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Broad-spectrum adaptive antibiotic resistance associated with pseudomonas aeruginosa mucin-dependent surfing motility

Sun, E., Gill, E. E., Falsafi, R., Yeung, A., Liu, S. & Hancock, R. E. W., Sep 2018, In : Antimicrobial Agents and Chemotherapy. 62, 9, e00848-18.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms

Haney, E. F., Brito-Sánchez, Y., Trimble, M. J., Mansour, S. C., Cherkasov, A. & Hancock, R., 1 Dec 2018, In : Scientific Reports. 8, 1, 1871.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides

Haney, E. F., Trimble, M. J., Cheng, J. T., Vallé, Q. & Hancock, R. E. W., Jun 2018, In : Biomolecules. 8, 2, 29.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Development of Molecularly Imprinted Polymers to Block Quorum Sensing and Inhibit Bacterial Biofilm Formation

Ma, L., Feng, S., Fuente-Núñez, C. D. L., Hancock, R. & Lu, X., 6 Jun 2018, In : ACS Applied Materials and Interfaces. 10, 22, p. 18450-18457 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Helicobacter pylori biofilm formation is differentially affected by common culture conditions, and proteins play a central role in the biofilm matrix

Windham, I. H., Servetas, S. L., Whitmire, J. M., Pletzer, D., Hancock, R. & Merrell, D. S., 1 Jul 2018, In : Applied and Environmental Microbiology. 84, 14, e00391-18.

Research output: Contribution to journalArticle

7 Citations (Scopus)

High-throughput detection of RNA processing in bacteria

Gill, E. E., Chan, L. S., Winsor, G. L., Dobson, N., Lo, R., Ho Sui, S. J., Dhillon, B. K., Taylor, P. K., Shrestha, R., Spencer, C., Hancock, R. E. W., Unrau, P. J. & Brinkman, F. S. L., 27 Mar 2018, In : BMC Genomics. 19, 1, 223.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Host defense (antimicrobial) peptides

Sun, E., Belanger, C. R., Haney, E. F. & Hancock, R., 1 Jan 2018, Peptide Applications in Biomedicine, Biotechnology and Bioengineering. Elsevier Inc., p. 253-285 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Host defense (antimicrobial) peptides

Sun, E., Belanger, C. R., Haney, E. F. & Hancock, R., 1 Jan 2018, Peptide Applications in Biomedicine, Biotechnology and Bioengineering. Elsevier Inc., p. 253-285 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment

Marin-Luevano, P., Trujillo, V., Rodriguez-Carlos, A., González-Curiel, I., Enciso-Moreno, J. A., Hancock, R. & Rivas-Santiago, B., 1 Mar 2018, In : Peptides. 101, p. 135-144 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)