Pirjo Apaja

Associate Professor

  • 598 Citations
  • 14 h-Index
20042019
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Research Output 2004 2019

  • 598 Citations
  • 14 h-Index
  • 17 Article
  • 2 Review article
  • 1 Chapter
2019

Single Cell Fluorescence Ratio Image Analysis for Studying ESCRT Function in Receptor Trafficking

Kazan, J. M., Lukacs, G. L., Apaja, P. & Pause, A., 1 Jan 2019, Methods in Molecular Biology. Humana Press Inc., p. 93-103 11 p. (Methods in Molecular Biology; vol. 1998)(Springer Protocols).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018
8 Citations (Scopus)

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase

Okiyoneda, T., Veit, G., Sakai, R., Aki, M., Fujihara, T., Higashi, M., Susuki-Miyata, S., Miyata, M., Fukuda, N., Yoshida, A., Xu, H., Apaja, P. M. & Lukacs, G. L., 26 Mar 2018, In : Developmental Cell. 44, 6, p. 694-708.e7

Research output: Contribution to journalArticle

2017
3 Citations (Scopus)
15 Citations (Scopus)

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Bagdany, M., Veit, G., Fukuda, R., Avramescu, R. G., Okiyoneda, T., Baaklini, I., Singh, J., Sovak, G., Xu, H., Apaja, P. M., Sattin, S., Beitel, L. K., Roldan, A., Colombo, G., Balch, W., Young, J. C. & Lukacs, G. L., 1 Dec 2017, In : Nature communications. 8, 1, 398.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl channel function and trafficking

Gaitán-Peñas, H., Apaja, P., Arnedo, T., Castellanos, A., Elorza-Vidal, X., Soto, D., Gasull, X., Lukacs, G. L. & Estévez, R., 15 Nov 2017, In : Journal of Physiology. 595, 22, p. 6993-7008 16 p.

Research output: Contribution to journalArticle

2016
20 Citations (Scopus)

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

Veit, G., Oliver, K., Apaja, P., Perdomo, D., Bidaud-Meynard, A., Lin, S. T., Guo, J., Icyuz, M., Sorscher, E. J., Hartman IV, J. L. & Lukacs, G. L., 11 May 2016, In : PLoS Biology. 14, 5, e1002462.

Research output: Contribution to journalArticle

2015
17 Citations (Scopus)

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

Kharitidi, D., Apaja, P., Manteghi, S., Suzuki, K., Malitskaya, E., Roldan, A., Gingras, M. C., Takagi, J., Lukacs, G. L. & Pause, A., 20 Oct 2015, In : Cell Reports. 13, 3, p. 599-609 11 p., 2076.

Research output: Contribution to journalArticle

2014
167 Citations (Scopus)

Cystic fibrosis: Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

Veit, G., Avramescu, R. G., Perdomo, D., Phuan, P. W., Bagdany, M., Apaja, P., Borot, F., Szollosi, D., Wu, Y. S., Finkbeiner, W. E., Hegedus, T., Verkman, A. S. & Lukacs, G. L., 23 Jul 2014, In : Science Translational Medicine. 6, 246, 246ra97.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells

Chu, C. Y., King, J., Berrini, M., Rumley, A. C., Apaja, P., Lukacs, G. L., Alexander, R. T. & Cordat, E., 1 Jan 2014, In : American Journal of Physiology - Cell Physiology. 307, 3

Research output: Contribution to journalArticle

18 Citations (Scopus)

Protein homeostasis at the plasma membrane

Apaja, P. & Lukacs, G. L., 1 Jul 2014, In : Physiology. 29, 4, p. 265-277 13 p.

Research output: Contribution to journalReview article

2013
19 Citations (Scopus)

Insights into MLC pathogenesis: GlialCAM is an MLC1 chaperone required for proper activation of volume-regulated anion currents

Capdevila-Nortes, X., López-Hernández, T., Apaja, P., de Heredia, M. L., Sirisi, S., Callejo, G., Arnedo, T., Nunes, V., Lukacs, G. L., Gasull, X. & Estévez, R., 1 Nov 2013, In : Human Molecular Genetics. 22, 21, p. 4405-4416 12 p., ddt290.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Ubiquitination-dependent quality control of hERG K+ channel with acquired and inherited conformational defect at the plasma membrane

Apaja, P., Foo, B., Okiyoneda, T., Valinsky, W. C., Barriere, H., Atanasiu, R., Ficker, E., Lukacs, G. L. & Shrier, A., 15 Dec 2013, In : Molecular Biology of the Cell. 24, 24, p. 3787-3804 18 p.

Research output: Contribution to journalArticle

2011
8 Citations (Scopus)

Endocytic sorting of CFTR variants monitored by single-cell fluorescence ratiometric image analysis (FRIA) in living cells.

Barrière, H., Apaja, P., Okiyoneda, T. & Lukacs, G. L., 7 Sep 2011, In : Methods in molecular biology (Clifton, N.J.). 741, p. 301-317 17 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Protein quality control at the plasma membrane

Okiyoneda, T., Apaja, P. & Lukacs, G. L., 1 Aug 2011, In : Current Opinion in Cell Biology. 23, 4, p. 483-491 9 p.

Research output: Contribution to journalReview article

2010
38 Citations (Scopus)

Quality control for unfolded proteins at the plasma membrane

Apaja, P., Xu, H. & Lukacs, G. L., 1 Nov 2010, In : Journal of Cell Biology. 191, 3, p. 553-570 18 p.

Research output: Contribution to journalArticle

2007
15 Citations (Scopus)

The Endoplasmic Reticulum Ca2+-pump SERCA2b Interacts with G Protein-coupled Receptors and Enhances their Expression at the Cell Surface

Tuusa, J. T., Markkanen, P. M. H., Apaja, P., Hakalahti, A. E. & Petäjä-Repo, U. E., 17 Aug 2007, In : Journal of Molecular Biology. 371, 3, p. 622-638 17 p.

Research output: Contribution to journalArticle

2006
42 Citations (Scopus)

Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum

Apaja, P., Tuusa, J. T., Pietilä, E. M., Rajaniemi, H. J. & Petäjä-Repo, U. E., 1 May 2006, In : Molecular Biology of the Cell. 17, 5, p. 2243-2255 13 p.

Research output: Contribution to journalArticle

2005
31 Citations (Scopus)

Expression of the mature luteinizing hormone receptor in rodent urogenital and adrenal tissues is developmentally regulated at a posttranslational level

Apaja, P., Aatsinki, J. T., Rajaniemi, H. J. & Petäjä-Repo, U. E., Aug 2005, In : Endocrinology. 146, 8, p. 3224-3232 9 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Inefficient maturation of the rat luteinizing hormone receptor: A putative way to regulate receptor numbers at the cell surface

Pietilä, E. M., Tuusa, J. T., Apaja, P., Aatsinki, J. T., Hakalahti, A. E., Rajaniemi, H. J. & Petäjä-Repo, U. E., 15 Jul 2005, In : Journal of Biological Chemistry. 280, 28, p. 26622-26629 8 p.

Research output: Contribution to journalArticle

2004
62 Citations (Scopus)

Identification and Structural Characterization of the Neuronal Luteinizing Hormone Receptor Associated with Sensory Systems

Apaja, P., Harju, K. T., Aatsinki, J. T., Petäjä-Repo, U. E. & Rajaniemi, H. J., 16 Jan 2004, In : Journal of Biological Chemistry. 279, 3, p. 1899-1906 8 p.

Research output: Contribution to journalArticle