Pirjo Apaja

Associate Professor

  • 545 Citations
  • 13 h-Index
20042018
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Personal profile

Public Profile

Pirjo has an international track record and a long term interest in protein networks regulating membrane trafficking disorders and proteostasis.

After completing a Ph.D. in processing and trafficking of G protein-coupled receptors in Finland, she continued her research into conformational diseases and protein trafficking disorders at the Hospital for Sick Children Research Institute, Toronto. As a senior scientist at McGill University, Montreal, Canada she further specialized in the regulation of the endo-lysosomal pathway, ubiquitin signalling and their role in the protein trafficking disorders leading to cancers, cystic fibrosis, astrocyte dysregulation and heart defects. Pirjo is currently EMBL Australia Group Leader in Organelle Biology and Disease at the South Australian Health and Medical Research (SAHMRI), Adelaide and Associate Professor in Molecular and Biomedical Sciences at the University of Adelaide.

Pirjo’s Organelle Biology and Disease Group is an experimental research group and is working towards understanding how the regulation of the endolysosome-autophagy pathway and dysfunction of it can lead to protein trafficking disorders. Her group employ advanced light microscopy to measure protein trafficking, signalling and organelle pH regulation, and proteomics and other biochemical and cell biological methods. Her group is investigating protein networks involved in cancers, Parkinson’s and behavioural diseases and in astrocyte osmotic stress. The aim of her research programme is to find targets at the organelle level.

Keywords

  • RZ Other systems of medicine
  • Parkinson's
  • Cancers
  • membranes
  • adaptor proteins
  • ubiquitin signalling
  • autophagy-lysosomes
  • osmotic stress
  • Neuronal disorders

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Research Output 2004 2018

  • 545 Citations
  • 13 h-Index
  • 17 Article
  • 2 Review article
4 Citations

Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase

Okiyoneda, T., Veit, G., Sakai, R., Aki, M., Fujihara, T., Higashi, M., Susuki-Miyata, S., Miyata, M., Fukuda, N., Yoshida, A., Xu, H., Apaja, P. M. & Lukacs, G. L. 26 Mar 2018 In : Developmental Cell. 44, 6, p. 694-708.e7

Research output: Research - peer-reviewArticle

9 Citations

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Bagdany, M., Veit, G., Fukuda, R., Avramescu, R. G., Okiyoneda, T., Baaklini, I., Singh, J., Sovak, G., Xu, H., Apaja, P. M., Sattin, S., Beitel, L. K., Roldan, A., Colombo, G., Balch, W., Young, J. C. & Lukacs, G. L. 1 Dec 2017 In : Nature Communications. 8, 1, 398

Research output: Research - peer-reviewArticle

2 Citations

Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl channel function and trafficking

Gaitán-Peñas, H., Apaja, P. M., Arnedo, T., Castellanos, A., Elorza-Vidal, X., Soto, D., Gasull, X., Lukacs, G. L. & Estévez, R. 15 Nov 2017 In : Journal of Physiology. 595, 22, p. 6993-7008 16 p.

Research output: Research - peer-reviewArticle

18 Citations

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

Veit, G., Oliver, K., Apaja, P. M., Perdomo, D., Bidaud-Meynard, A., Lin, S. T., Guo, J., Icyuz, M., Sorscher, E. J., Hartman IV, J. L. & Lukacs, G. L. 11 May 2016 In : PLoS Biology. 14, 5, e1002462

Research output: Research - peer-reviewArticle