Paul Thomas

Professor, PhD

  • 6517 Citations
  • 38 h-Index
1992 …2020

Research output per year

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Research Output

2020

Distribution of Parkinson's disease associated RAB39B in mouse brain tissue

Gao, Y., Wilson, G. R., Stephenson, S. E. M., Oulad-Abdelghani, M., Charlet-Berguerand, N., Bozaoglu, K., McLean, C. A., Thomas, P., Finkelstein, D. I. & Lockhart, P. J., 30 Mar 2020, In : Molecular brain. 13, 1, 52.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy

Dawson, R. E., Nieto Guil, A. F., Robertson, L., Piltz, S., Hughes, J. N. & Thomas, P., 1 Feb 2020, In : Neurobiology of Disease. 134, 104640.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genetic Biocontrol for Invasive Species

Teem, J. L., Alphey, L., Descamps, S., Edgington, M. P., Edwards, O., Gemmell, N., Harvey-Samuel, T., Melnick, R. L., Oh, K. P., Piaggio, A. J., Saah, J. R., Schill, D., Thomas, P., Smith, T. & Roberts, A., 25 May 2020, In : Frontiers in Bioengineering and Biotechnology. 8, 452.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Investigating cortical features of Sotos syndrome using mice heterozygous for Nsd1

Oishi, S., Zalucki, O., Vega, M. S., Harkins, D., Harvey, T. J., Kasherman, M., Davila, R. A., Hale, L., White, M., Piltz, S., Thomas, P., Burne, T. H. J., Harris, L. & Piper, M., 1 Apr 2020, In : Genes, Brain and Behavior. 19, 4, e12637.

Research output: Contribution to journalArticle

SOX3 promotes generation of committed spermatogonia in postnatal mouse testes

McAninch, D., Mäkelä, J. A., La, H. M., Hughes, J. N., Lovell-Badge, R., Hobbs, R. M. & Thomas, P., 1 Dec 2020, In : Scientific Reports. 10, 1, 6751.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice

Bagheri-Fam, S., Chen, H., Wilson, S., Ayers, K., Hughes, J., Sloan-Bena, F., Calvel, P., Robevska, G., Puisac, B., Kusz-Zamelczyk, K., Gimelli, S., Spik, A., Jaruzelska, J., Warenik-Szymankiewicz, A., Faradz, S., Nef, S., Pié, J., Thomas, P., Sinclair, A. & Wilhelm, D., 1 Jan 2020, In : PloS one. 15, 1, e0227411.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

Prowse, T. A., Adikusuma, F., Cassey, P., Thomas, P. & Ross, J. V., Feb 2019, In : eLife. 8, e41873.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Locally Fixed Alleles: A method to localize gene drive to island populations

Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., Edwards, O., Godwin, J., Howald, G. R., Oh, K. P., Piaggio, A. J., Prowse, T. A. A., Ross, J. V., Saah, J. R., Shiels, A. B., Thomas, P., Threadgill, D. W., Vella, M. R., Gould, F. & Lloyd, A. L., 1 Dec 2019, In : Scientific Reports. 9, 1, 15821.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Paroxysmal and cognitive phenotypes in Prrt2 mutant mice

Robertson, L., Featherby, T., Howell, S., Hughes, J. & Thomas, P., 1 Jun 2019, In : Genes, Brain and Behavior. 18, 5, e12566.

Research output: Contribution to journalArticle

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., 26 Aug 2019, In : Genome biology. 20, 1, 171.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Rodent gene drives for conservation: Opportunities and data needs

Godwin, J., Serr, M., Barnhill-Dilling, S. K., Blondel, D. V., Brown, P. R., Campbell, K., Delborne, J., Lloyd, A. L., Oh, K. P., Prowse, T. A. A., Saah, R. & Thomas, P., 6 Nov 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1914, 20191606.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy

Pederick, D. T., Richards, K. L., Piltz, S. G., Kumar, R., Mincheva-Tasheva, S., Mandelstam, S. A., Dale, R. C., Scheffer, I. E., Gecz, J., Petrou, S., Hughes, J. N. & Thomas, P. Q., 3 Jan 2018, In : Neuron. 97, 1, p. 59-66.e5

Research output: Contribution to journalArticle

30 Citations (Scopus)

Expanding the RNA-Guided Endonuclease Toolkit for Mouse Genome Editing

Robertson, L., Pederick, D., Piltz, S., White, M., Nieto, A., Ahladas, M., Adikusuma, F. & Thomas, P. Q., Dec 2018, In : The CRISPR journal. 1, p. 431-439 9 p.

Research output: Contribution to journalArticle

Large deletions induced by Cas9 cleavage

Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T. & Thomas, P., 9 Aug 2018, In : Nature. 560, 7717, p. E8-E9

Research output: Contribution to journalArticle

46 Citations (Scopus)

Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice

Masedunskas, A., Appaduray, M. A., Lucas, C. A., Cagigas, M. L., Heydecker, M., Holliday, M., Meiring, J. C. M., Hook, J., Kee, A., White, M., Thomas, P., Zhang, Y., Adelstein, R. S., Meckel, T., Böcking, T., Weigert, R., Bryce, N. S., Gunning, P. W. & Hardeman, E. C., 1 Mar 2018, In : Journal of Cell Science. 131, 6, jcs212654.

Research output: Contribution to journalArticle

9 Citations (Scopus)

PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy

Homan, C. C., Pederson, S., To, T. H., Tan, C., Piltz, S., Corbett, M. A., Wolvetang, E., Thomas, P. Q., Jolly, L. A. & Gecz, J., 1 Aug 2018, In : Neurobiology of Disease. 116, p. 106-119 14 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Pest demography critically determines the viability of synthetic gene drives for population control

Wilkins, K. E., Prowse, T. A. A., Cassey, P., Thomas, P. & Ross, J. V., 1 Nov 2018, In : Mathematical Biosciences. 305, p. 160-169 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Caspase-2-mediated cell death is required for deleting aneuploid cells

Dawar, S., Lim, Y., Puccini, J., White, M., Thomas, P., Bouchier-Hayes, L., Green, D. R., Dorstyn, L. & Kumar, S., 11 May 2017, In : Oncogene. 36, 19, p. 2704-2714 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Dodging silver bullets: Good CRISPR gene-drive design is critical for eradicating exotic vertebrates

Prowse, T. A. A., Cassey, P., Ross, J. V., Pfitzner, C., Wittmann, T. A. & Thomas, P., 16 Aug 2017, In : Proceedings of the Royal Society B: Biological Sciences. 284, 1860, 20170799.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Functional equivalence of the SOX2 and SOX3 transcription factors in the developing mouse brain and testes

Adikusuma, F., Pederick, D., McAninch, D., Hughes, J. & Thomas, P., 1 Jul 2017, In : Genetics. 206, 3, p. 1495-1503 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling

Hughes, J., Dawson, R., Tea, M., McAninch, D., Piltz, S., Jackson, D., Stewart, L., Ricos, M. G., Dibbens, L. M., Harvey, N. L. & Thomas, P., 1 Dec 2017, In : Scientific reports. 7, 1, 12618.

Research output: Contribution to journalArticle

23 Citations (Scopus)

NAD deficiency, congenital malformations, and niacin supplementation

Shi, H., Enriquez, A., Rapadas, M., Martin, E. M. M. A., Wang, R., Moreau, J., Lim, C. K., Szot, J. O., Ip, E., Hughes, J. N., Sugimoto, K., Humphreys, D. T., McInerney-Leo, A. M., Leo, P. J., Maghzal, G. J., Halliday, J., Smith, J., Colley, A., Mark, P. R., Collins, F. & 13 others, Sillence, D. O., Winlaw, D. S., Ho, J. W. K., Guillemin, G. J., Brown, M. A., Kikuchi, K., Thomas, P. Q., Stocker, R., Giannoulatou, E., Chapman, G., Duncan, E. L., Sparrow, D. B. & Dunwoodie, S. L., 10 Aug 2017, In : New England Journal of Medicine. 377, 6, p. 544-552 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Protocadherin 19 (PCDH19) interacts with paraspeckle protein NONO to co-regulate gene expression with estrogen receptor alpha (ERα)

Pham, D. H., Tan, C. C., Homan, C. C., Kolc, K. L., Corbett, M. A., McAninch, D., Fox, A. H., Thomas, P. Q., Kumar, R. & Gecz, J., 1 Jan 2017, In : Human Molecular Genetics. 26, 11, p. 2042-2052 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9

Adikusuma, F., Williams, N., Grutzner, F., Hughes, J. & Thomas, P., 2 Aug 2017, In : Molecular Therapy. 25, 8, p. 1736-1738 3 p.

Research output: Contribution to journalLetter

23 Citations (Scopus)

Versatile single-step-assembly CRISPR/Cas9 vectors for dual gRNA expression

Adikusuma, F., Pfitzner, C. & Thomas, P., Dec 2017, In : PloS one. 12, 12, e0187236.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Viperin is an important host restriction factor in control of Zika virus infection

Van Der Hoek, K. H., Eyre, N. S., Shue, B., Khantisitthiporn, O., Glab-Ampi, K., Carr, J. M., Gartner, M. J., Jolly, L. A., Thomas, P., Adikusuma, F., Jankovic-Karasoulos, T., Roberts, C. T., Helbig, K. J. & Beard, M. R., 1 Dec 2017, In : Scientific reports. 7, 1, 4475.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2016

Derivation of an endogenous small RNA from double-stranded Sox4 sense and natural antisense transcripts in the mouse brain

Ling, K. H., Brautigan, P. J., Moore, S., Fraser, R., Cheah, P. S., Raison, J. M., Babic, M., Lee, Y. K., Daish, T., Mattiske, D. M., Mann, J. R., Adelson, D. L., Thomas, P. Q., Hahn, C. N. & Scott, H. S., 1 Mar 2016, In : Genomics. 107, 2-3, p. 88-99 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Identification of an IGSF1-specific deletion in a five-generation pedigree with X-linked Central Hypothyroidism without macroorchidism

Hughes, J. N., Aubert, M., Heatlie, J., Gardner, A., Gecz, J., Morgan, T., Belsky, J. & Thomas, P. Q., 1 Oct 2016, In : Clinical Endocrinology. 85, 4, p. 609-615 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts

Ling, K. H., Brautigan, P. J., Moore, S., Fraser, R., Leong, M. P. Y., Leong, J. W., Zainal Abidin, S., Lee, H. C., Cheah, P. S., Raison, J. M., Babic, M., Lee, Y. K., Daish, T., Mattiske, D. M., Mann, J. R., Adelson, D. L., Thomas, P., Hahn, C. N. & Scott, H. S., 1 Jun 2016, In : Data in Brief. 7, p. 282-290 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy

Ricos, M. G., Hodgson, B. L., Pippucci, T., Saidin, A., Ong, Y. S., Heron, S. E., Licchetta, L., Bisulli, F., Bayly, M. A., Hughes, J., Baldassari, S., Palombo, F., Santucci, M., Meletti, S., Berkovic, S. F., Rubboli, G., Thomas, P., Scheffer, I. E., Tinuper, P., Geoghegan, J. & 2 others, Schreiber, A. W. & Dibbens, L. M., 1 Jan 2016, In : Annals of Neurology. 79, 1, p. 120-131 12 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Pcdh19 Loss-of-Function Increases Neuronal Migration In Vitro but is Dispensable for Brain Development in Mice

Pederick, D. T., Homan, C. C., Jaehne, E. J., Piltz, S. G., Haines, B. P., Baune, B. T., Jolly, L. A., Hughes, J. N., Gecz, J. & Thomas, P. Q., 31 May 2016, In : Scientific reports. 6, 26765.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2015

Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX

Vidovic, D., Harris, L., Harvey, T. J., Evelyn Heng, Y. H., Smith, A. G., Osinski, J., Hughes, J., Thomas, P., Gronostajski, R. M., Bailey, T. L. & Piper, M., 1 Jan 2015, In : Brain Research. 1616, p. 71-87 17 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Interchromosomal insertional translocation at Xq26.3 alters SOX3 expression in an individual with XX male sex reversal

Haines, B., Hughes, J., Corbett, M., Shaw, M., Innes, J., Patel, L., Gecz, J., Clayton-Smith, J. & Thomas, P., 1 May 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 5, p. E815-E820

Research output: Contribution to journalArticle

25 Citations (Scopus)

Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency

Tan, C., Shard, C., Ranieri, E., Hynes, K., Pham, D. H., Leach, D., Buchanan, G., Corbett, M., Shoubridge, C., Kumar, R., Douglas, E., Nguyen, L. S., Mcmahon, J., Sadleir, L., Specchio, N., Marini, C., Guerrini, R., Moller, R. S., Depienne, C., Haan, E. & 4 others, Thomas, P. Q., Berkovic, S. F., Scheffer, I. E. & Gecz, J., 9 Apr 2015, In : Human Molecular Genetics. 24, 18, p. 5250-5259 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation

Polling, S., Ormsby, A. R., Wood, R. J., Lee, K., Shoubridge, C., Hughes, J. N., Thomas, P., Griffin, M. D. W., Hill, A. F., Bowden, Q., Böcking, T. & Hatters, D. M., 1 Dec 2015, In : Nature Structural and Molecular Biology. 22, 12, p. 1008-1015 8 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

SOX3 expression in the glial system of the developing and adult mouse cerebellum

Cheah, P. S. & Thomas, P. Q., 8 Dec 2015, In : SpringerPlus. 4, 1, 400.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2014

A reduction in Npas4 expression results in delayed neural differentiation of mouse embryonic stem cells

Klaric, T. S., Thomas, P. Q., Dottori, M., Leong, W. K., Koblar, S. A. & Lewis, M. D., 8 May 2014, In : Stem Cell Research and Therapy. 5, 3, 64.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Dbx1 is a direct target of SOX3 in the spinal cord

Rogers, N., McAninch, D. & Thomas, P., 21 Apr 2014, In : PloS one. 9, 4, e95356.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of highly conserved putative developmental enhancers bound by SOX3 in neural progenitors using ChIP-Seq

McAninch, D. & Thomas, P., 19 Nov 2014, In : PloS one. 9, 11, e113361.

Research output: Contribution to journalArticle

17 Citations (Scopus)

SOX3 deletion in mouse and human is associated with persistence of the craniopharyngeal canal

Alatzoglou, K. S., Azriyanti, A., Rogers, N., Ryan, F., Curry, N., Noakes, C., Bignell, P., Hall, G. W., Littooij, A. S., Saunders, D., Thomas, P., Stewart, H. & Dattani, M. T., 1 Dec 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. E2702-E2708

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis

Rogers, N., Cheah, P. S., Szarek, E., Banerjee, K., Schwartz, J. & Thomas, P., 4 Jun 2013, In : Gene Expression Patterns. 13, 7, p. 240-248 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Mammalian Sex Determination and Gonad Development

Wilhelm, D., Yang, J. X. & Thomas, P., 1 Jan 2013, Current Topics in Developmental Biology. Academic Press Inc., p. 89-121 33 p. (Current Topics in Developmental Biology; vol. 106).

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism

Hughes, J., Piltz, S., Rogers, N., McAninch, D., Rowley, L. & Thomas, P., 15 Apr 2013, In : PLoS Genetics. 9, 3, e1003290.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Molecular pathology of polyalanine expansion disorders: New perspectives from mouse models

Hughes, J. N. & Thomas, P., 3 Sep 2013, Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols. p. 135-151 17 p. (Methods in Molecular Biology; vol. 1017).

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)

Mutations in DEPDC5 cause familial focal epilepsy with variable foci

Dibbens, L. M., De Vries, B., Donatello, S., Heron, S. E., Hodgson, B. L., Chintawar, S., Crompton, D. E., Hughes, J. N., Bellows, S. T., Klein, K. M., Callenbach, P. M. C., Corbett, M. A., Gardner, A. E., Kivity, S., Iona, X., Regan, B. M., Weller, C. M., Crimmins, D., O'Brien, T. J., Guerrero-López, R. & 15 others, Mulley, J. C., Dubeau, F., Licchetta, L., Bisulli, F., Cossette, P., Thomas, P. Q., Gecz, J., Serratosa, J., F Brouwer, O., Andermann, F., Andermann, E., Van Den Maagdenberg, A. M. J. M., Pandolfo, M., Berkovic, S. F. & Scheffer, I. E., 1 May 2013, In : Nature Genetics. 45, 5, p. 546-551 6 p.

Research output: Contribution to journalArticle

189 Citations (Scopus)
2012

Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice

Lee, K., Tan, J., Morris, M. B., Rizzoti, K., Hughes, J., Cheah, P. S., Felquer, F., Liu, X., Piltz, S., Lovell-Badge, R. & Thomas, P., 26 Jan 2012, In : PloS one. 7, 1, e29041.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity

Cirillo, J., Hughes, J., Ridding, M., Thomas, P. & Semmler, J. G., 1 Sep 2012, In : European Journal of Neuroscience. 36, 5, p. 2640-2649 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)