Paul Thomas

Professor, PhD

  • 6077 Citations
  • 35 h-Index
1992 …2020
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Personal profile

Public Profile

Prof Paul Thomas leads the Genome Editing Laboratory and SA Genome Editing Facility at the University of Adelaide and South Australian Health and Medical Research Institute. 

Prof Thomas completed his Ph.D. at the University of Adelaide in 1994. He then moved to the National Institute for Medical Research (London) and completed a 3 year post-doctoral position with the late Dr. Rosa Beddington, who was a world-leader in the field of developmental biology. In 1998, he retuned to Australia with the support of a NHMRC Florey Fellowship and established an independent research group at the Murdoch Institute in Melbourne.  In 2006, he moved to the University of Adelaide and in 2008 was awarded a prestigious Pfizer Australia Research Fellowship. In 2014 he was promoted to full Professor and established the SA Genome Editing (SAGE) facility. In 2018, he relocated to the South Australian Health and Medical Research Institute. 

 

 

Research Interests

Prof Thomas's research focuses on the development of CRISPR/CAS9 genome editing technology for a range of applications including generation and analysis of mouse models for neurodevelopmental disorders and synthetic gene drives for invasive pest suppression. He has published more than 80 scientific articles with >7,000 citations. His research is supported by the USA Defense Advanced Research Projects Agency (DARPA) and the NHMRC.

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Research Output 1992 2020

Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy

Dawson, R. E., Nieto Guil, A. F., Robertson, L. J., Piltz, S., Hughes, J. N. & Thomas, P., 1 Feb 2020, In : Neurobiology of Disease. 134, 104640.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

Prowse, T. A., Adikusuma, F., Cassey, P., Thomas, P. & Ross, J. V., 1 Feb 2019, In : eLife. 8, e41873.

Research output: Contribution to journalArticle

Locally Fixed Alleles: A method to localize gene drive to island populations

Sudweeks, J., Hollingsworth, B., Blondel, D. V., Campbell, K. J., Dhole, S., Eisemann, J. D., Edwards, O., Godwin, J., Howald, G. R., Oh, K. P., Piaggio, A. J., Prowse, T. A. A., Ross, J. V., Saah, J. R., Shiels, A. B., Thomas, P., Threadgill, D. W., Vella, M. R., Gould, F. & Lloyd, A. L., 1 Dec 2019, In : Scientific Reports. 9, 1, 15821.

Research output: Contribution to journalArticle

Paroxysmal and cognitive phenotypes in Prrt2 mutant mice

Robertson, L., Featherby, T., Howell, S., Hughes, J. & Thomas, P., 1 Jun 2019, In : Genes, Brain and Behavior. 18, 5, e12566.

Research output: Contribution to journalArticle

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: A multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M. C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M., Eudy, J. D. & 93 othersGan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N. C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X. D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y. I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J. F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., 26 Aug 2019, In : Genome Biology. 20, 1, 171.

Research output: Contribution to journalArticle