Paul Thomas

Professor, PhD

  • 5913 Citations
  • 34 h-Index
1992 …2019
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Personal profile

Public Profile

Prof Paul Thomas leads the Genome Editing Laboratory and SA Genome Editing Facility at the University of Adelaide and South Australian Health and Medical Research Institute. 

Prof Thomas completed his Ph.D. at the University of Adelaide in 1994. He then moved to the National Institute for Medical Research (London) and completed a 3 year post-doctoral position with the late Dr. Rosa Beddington, who was a world-leader in the field of developmental biology. In 1998, he retuned to Australia with the support of a NHMRC Florey Fellowship and established an independent research group at the Murdoch Institute in Melbourne.  In 2006, he moved to the University of Adelaide and in 2008 was awarded a prestigious Pfizer Australia Research Fellowship. In 2014 he was promoted to full Professor and established the SA Genome Editing (SAGE) facility. In 2018, he relocated to the South Australian Health and Medical Research Institute. 

 

 

Research Interests

Prof Thomas's research focuses on the development of CRISPR/CAS9 genome editing technology for a range of applications including generation and analysis of mouse models for neurodevelopmental disorders and synthetic gene drives for invasive pest suppression. He has published more than 80 scientific articles with >7,000 citations. His research is supported by the USA Defense Advanced Research Projects Agency (DARPA) and the NHMRC.

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Research Output 1992 2019

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

Prowse, T. A., Adikusuma, F., Cassey, P., Thomas, P. & Ross, J. V., 1 Feb 2019, In : eLife. 8, e41873.

Research output: Contribution to journalArticle

Paroxysmal and cognitive phenotypes in Prrt2 mutant mice

Robertson, L., Featherby, T., Howell, S., Hughes, J. & Thomas, P., 1 Jun 2019, In : Genes, Brain and Behavior. 18, 5, e12566.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy

Pederick, D. T., Richards, K. L., Piltz, S. G., Kumar, R., Mincheva-Tasheva, S., Mandelstam, S. A., Dale, R. C., Scheffer, I. E., Gecz, J., Petrou, S., Hughes, J. N. & Thomas, P. Q., 3 Jan 2018, In : Neuron. 97, 1, p. 59-66.e5

Research output: Contribution to journalArticle

Expanding the RNA-Guided Endonuclease Toolkit for Mouse Genome Editing

Robertson, L., Pederick, D., Piltz, S., White, M., Nieto, A., Ahladas, M., Adikusuma, F. & Thomas, P. Q., Dec 2018, In : The CRISPR journal. 1, p. 431-439 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Large deletions induced by Cas9 cleavage

Adikusuma, F., Piltz, S., Corbett, M. A., Turvey, M., McColl, S. R., Helbig, K. J., Beard, M. R., Hughes, J., Pomerantz, R. T. & Thomas, P., 9 Aug 2018, In : Nature. 560, 7717, p. E8-E9

Research output: Contribution to journalArticle