• 238 Citations
  • 6 h-Index

Research output per year

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Personal profile

Public Profile

Dr. Mark van den Hurk obtained his Ph.D. in Translational Neuropsychiatry from Maastricht University (Maastricht, The Netherlands) in 2016. As part of a collaborative Ph.D. study, he carried out most of his doctoral research in the Laboratory of Genetics of Prof. Fred Gage at the Salk Institute for Biological Studies in San Diego, California. There, under the supervision of Dr. Cedric Bardy, he developed a practical pipeline for the molecular characterization of individual human stem cell-derived neurons using single-cell RNA-sequencing. Dr. van den Hurk has been appointed to continue his work as a postdoctoral research officer in Dr. Bardy’s recently established Laboratory for Human Neurophysiology and Genetics at SAHMRI Lifelong Health. His research interests revolve around neuropsychiatric disease biology and molecular genetics; specifically, he is interested in unraveling how genetic disease predispositions may disturb molecular pathways and contribute to the development of human neurological and psychiatric illness.

Research Interests

  • Neuropsychiatric genetics
  • Molecular genetics of complex disease
  • Human stem cell biology
  • Neuronal differentiation and maturation
  • Bioinformatics

Education/Academic qualification

PhD, Maastricht University

1 Sep 201213 Dec 2016

Masters, Maastricht University

1 Sep 201031 Jul 2012

Certificate, Maastricht University

Bachelor's Degree, Maastricht University

1 Sep 200731 Aug 2010

External positions

Research Scholar, Salk Institute for Biological Studies

Nov 2011Jun 2014


  • single-cell transcriptomics
  • single-cell RNA-seq
  • genomics
  • induced pluripotent stem cells (iPSCs)
  • neuronal tissue engineering
  • in vitro disease modeling
  • Patch-seq
  • cellular phenotyping

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Research Output

  • 238 Citations
  • 6 h-Index
  • 3 Article
  • 3 Review article
  • 2 Comment/debate

Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

Bardy, C., Van Den Hurk, M., Kakaradov, B., Erwin, J. A., Jaeger, B. N., Hernandez, R. V., Eames, T., Paucar, A. A., Gorris, M., Marchand, C., Jappelli, R., Barron, J., Bryant, A. K., Kellogg, M., Lasken, R. S., Rutten, B. P. F., Steinbusch, H. W. M., Yeo, G. W. & Gage, F. H., 1 Nov 2016, In : Molecular Psychiatry. 21, 11, p. 1573-1588 16 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency

Van Den Hurk, M., Kenis, G., Bardy, C., Van Den Hove, D. L., Gage, F. H., Steinbusch, H. W. & Rutten, B. P., Aug 2016, In : Epigenomics. 8, 8, p. 1131-1149 19 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)