• 472 Citations
  • 11 h-Index
20102018
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Personal profile

Public Profile

Dr. Mark Bunting is a post-doctoral researcher in the Genome Editing Laboratory at the University of Adelaide and South Australian Health and Medical Research Institute (SAHRMI). The lab is directed by Prof. Paul Thomas.

 

Dr. Mark Bunting completed his Ph.D. in Immunology at the University of Adelaide in 2012. He then joined the lab of Prof. Geoff Hill at the QIMR Berghofer Medical Research Institute in Brisbane, Australia studying the role of mucosal associated invariant T cells (MAIT) and natural killer cells in graft-versus-host disease and leukemia preclinical models. He then undertook a second post-doctoral position in the lab of Assistant Prof. Shawn Demehri at the Massachusetts General Hospital & Harvard Medical School in Boston, USA. Here he researched the role of natural killer cells in solid organ transplantion and skin cancer preclinical models. In 2019 he moved back to Adelaide and joined the Genome Editing Laboratory.

Research Interests

Dr. Bunting's research is centred around using CRISPR/Cas9 genome editing technology to develop gene drive technology in mammals. The aim of the project is to establish efficient gene drives as a safe and ethical method of invasive pest species control.

Education/Academic qualification

PhD, The University of Adelaide

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Research Output 2010 2018

  • 472 Citations
  • 11 h-Index
  • 9 Article
  • 3 Review article
12 Citations (Scopus)

Recipient mucosal-associated invariant T cells control GVHD within the colon

Varelias, A., Bunting, M. D., Ormerod, K. L., Koyama, M., Olver, S. D., Straube, J., Kuns, R. D., Robb, R. J., Henden, A. S., Cooper, L., Lachner, N., Gartlan, K. H., Lantz, O., Kjer-Nielsen, L., Mak, J. Y., Fairlie, D. P., Clouston, A. D., McCluskey, J., Rossjohn, J., Lane, S. W. & 2 othersHugenholtz, P. & Hill, G. R., 1 May 2018, In : Journal of Clinical Investigation. 128, 5, p. 1919-1936 18 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R., 13 Apr 2017, In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Bunting, M. D., Varelias, A., Souza-Fonseca-Guimaraes, F., Schuster, I. S., Lineburg, K. E., Kuns, R. D., Fleming, P., Locke, K. R., Huntington, N. D., Blazar, B. R., Lane, S. W., Tey, S-K., MacDonald, K. P. A., Smyth, M. J., Degli-Esposti, M. A. & Hill, G. R., 2 Feb 2017, In : Blood. 129, 5, p. 630-642 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease

Koyama, M., Cheong, M., Markey, K. A., Gartlan, K. H., Kuns, R. D., Locke, K. R., Lineburg, K. E., Teal, B. E., Leveque-El Mouttie, L., Bunting, M. D., Vuckovic, S., Zhang, P., Teng, M. W. L., Varelias, A., Tey, S-K., Wockner, L. F., Engwerda, C. R., Smyth, M. J., Belz, G. T., McColl, S. R. & 2 othersMacDonald, K. P. A. & Hill, G. R., 27 Jul 2015, In : Journal of Experimental Medicine. 212, 8, p. 1303-21 19 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects

Gartlan, K. H., Markey, K. A., Varelias, A., Bunting, M. D., Koyama, M., Kuns, R. D., Raffelt, N. C., Olver, S. D., Lineburg, K. E., Cheong, M., Teal, B. E., Lor, M., Comerford, I., Teng, M. W. L., Smyth, M. J., McCluskey, J., Rossjohn, J., Stockinger, B., Boyle, G. M., Lane, S. W. & 4 othersClouston, A. D., McColl, S. R., MacDonald, K. P. A. & Hill, G. R., 24 Sep 2015, In : Blood. 126, 13, p. 1609-20 12 p.

Research output: Contribution to journalArticle