Louise O'Keefe

Dr, PhD

  • 1727 Citations
  • 17 h-Index
1993 …2020

Research output per year

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Personal profile

Public Profile

Louise O’Keefe obtained her PhD studying cytokinesis in Drosophila and was subsequently awarded an NHRMC Peter Doherty Post-Doctoral training Fellowship to develop Drosophila as a genetic system to understand complex human diseases. She is currently a Research Officer at SAHMRI with a focus on using Drosophila to determine the cellular pathways and processes that contribute to neuronal cell loss in dementia.

Education/Academic qualification

PhD, University of Adelaide

External positions

University Research Fellow, University of Adelaide

1 Jan 2002 → …


  • Drosophila
  • Dementia
  • Alzheimer's disease
  • Lysosome
  • Autophagy
  • Ageing

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Research Output

  • 1727 Citations
  • 17 h-Index
  • 26 Article
  • 3 Review article
  • 2 Comment/debate
  • 1 Chapter

Drosophila as a model to understand autophagy deregulation in human disorders

Denton, D., O'Keefe, L. & Kumar, S., 2020, Progress in Molecular Biology and Translational Science. Martinez, A. B. & Galluzzi, L. (eds.). Elsevier B.V., p. 375-409 35 p. (Progress in Molecular Biology and Translational Science; vol. 172).

Research output: Chapter in Book/Report/Conference proceedingChapter

Non-self mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases

van Eyk, C. L., Samaraweera, S. E., Scott, A., Webber, D. L., Harvey, D. P., Mecinger, O., O’Keefe, L. V., Cropley, J. E., Young, P., Ho, J., Suter, C. & Richards, R. I., 1 Sep 2019, In : Human Molecular Genetics. 28, 18, p. 3000-3012 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Modulates Lifespan

Xie, J., de Souza Alves, V., von der Haar, T., O'Keefe, L., Lenchine, R. V., Jensen, K. B., Liu, R., Coldwell, M. J., Wang, X. & Proud, C. G., 4 Feb 2019, In : Current Biology. 29, 5

Research output: Contribution to journalArticle

6 Citations (Scopus)

CRISPR/Cas9-mediated mutagenesis of the white gene in the tephritid pest Bactrocera tryoni

Choo, A., Crisp, P., Saint, R., O'Keefe, L. V. & Baxter, S. W., 1 Feb 2018, In : Journal of Applied Entomology. 142, 1-2, p. 52-58 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Using Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer's Disease

O'Keefe, L. & Denton, D., 2018, In : BioMed Research International. 2018, p. 5195416

Research output: Contribution to journalReview article

5 Citations (Scopus)